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Grant Details

Grant Number: 5R01CA084979-05 Interpret this number
Primary Investigator: Ingles, Sue
Organization: University Of Southern California
Project Title: Risk Factors for Advanced Prostate Cancer
Fiscal Year: 2003


Abstract

Risk factors for advanced prostate cancer are poorly understood, but appear to differ from risk factors for occult disease. Although previous studies implicate both genetic and dietary factors in prostate cancer progression, attributable risk estimates for any single factor are not high. The possibility that genetic susceptibility might be expressed only in combination with dietary or other environmental exposures is the focus of this proposal. By examining genetic and dietary influences together, we may be able to identify important risk factors that are obscured when genes or diet are examined in isolation. Specifically, we hypothesize that allelic variation in genes controlling proliferation (androgen pathway genes) and differentiation (the vitamin D receptor gene) of prostate epithelium will influence risk of advanced prostate cancer, and that risk will be further modified by environmental (especially dietary) factors. We will address the following questions. 1. Are polymorphisms in androgen pathway genes associated with risk of advanced prostate cancer? 2. Does dietary fat or fiber intake modify risk of advanced prostate cancer among men with high- or low-risk genotypes? 3. Are polymorphisms in the vitamin D receptor gene associated with risk of advanced prostate cancer? 4. Does dietary calcium intake or vitamin D status (as measured by sunlight exposure and dietary intake) modify risk of advanced prostate cancer among men with high- or low-risk VDR genotypes? To address these questions, we propose to conduct a case-control study of 1000 men with advanced prostate cancer (500 Latino and 500 non-Latino white) ascertained through the Los Angeles County Cancer Surveillance Program, using neighborhood controls. Dietary and risk-factor questionnaires and blood samples will be collected. Odds ratios and effect modification will be evaluated using standard epidemiologic methods.



Publications

A genome-wide association study of prostate cancer in Latinos.
Authors: Du Z. , Hopp H. , Ingles S.A. , Huff C. , Sheng X. , Weaver B. , Stern M. , Hoffmann T.J. , John E.M. , Van Den Eeden S.K. , et al. .
Source: International journal of cancer, 2020-04-01; 146(7), p. 1819-1826.
EPub date: 2019-07-03.
PMID: 31226226
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A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.
Authors: Du Z. , Weinhold N. , Song G.C. , Rand K.A. , Van Den Berg D.J. , Hwang A.E. , Sheng X. , Hom V. , Ailawadhi S. , Nooka A.K. , et al. .
Source: Blood advances, 2020-01-14; 4(1), p. 181-190.
PMID: 31935283
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Impact of individual and neighborhood factors on disparities in prostate cancer survival.
Authors: DeRouen M.C. , Schupp C.W. , Koo J. , Yang J. , Hertz A. , Shariff-Marco S. , Cockburn M. , Nelson D.O. , Ingles S.A. , John E.M. , et al. .
Source: Cancer epidemiology, 2018 04; 53, p. 1-11.
EPub date: 2018-01-09.
PMID: 29328959
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Tobacco smoking, polymorphisms in carcinogen metabolism enzyme genes, and risk of localized and advanced prostate cancer: results from the California Collaborative Prostate Cancer Study.
Authors: Shahabi A. , Corral R. , Catsburg C. , Joshi A.D. , Kim A. , Lewinger J.P. , Koo J. , John E.M. , Ingles S.A. , Stern M.C. .
Source: Cancer medicine, 2014 Dec; 3(6), p. 1644-55.
EPub date: 2014-10-30.
PMID: 25355624
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A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
Authors: Al Olama A.A. , Kote-Jarai Z. , Berndt S.I. , Conti D.V. , Schumacher F. , Han Y. , Benlloch S. , Hazelett D.J. , Wang Z. , Saunders E. , et al. .
Source: Nature genetics, 2014 Oct; 46(10), p. 1103-9.
EPub date: 2014-09-14.
PMID: 25217961
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LHRH and LHR genotypes and prostate cancer incidence and survival.
Authors: Ingles S.A. , Liu S.V. , Pinski J. .
Source: International journal of molecular epidemiology and genetics, 2013; 4(4), p. 228-34.
EPub date: 2013-11-28.
PMID: 24319538
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Global patterns of prostate cancer incidence, aggressiveness, and mortality in men of african descent.
Authors: Rebbeck T.R. , Devesa S.S. , Chang B.L. , Bunker C.H. , Cheng I. , Cooney K. , Eeles R. , Fernandez P. , Giri V.N. , Gueye S.M. , et al. .
Source: Prostate cancer, 2013; 2013, p. 560857.
EPub date: 2013-02-13.
PMID: 23476788
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Protective effects of low calcium intake and low calcium absorption vitamin D receptor genotype in the California Collaborative Prostate Cancer Study.
Authors: Rowland G.W. , Schwartz G.G. , John E.M. , Ingles S.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013 Jan; 22(1), p. 16-24.
EPub date: 2012-11-05.
PMID: 23129590
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Red meat and poultry, cooking practices, genetic susceptibility and risk of prostate cancer: results from a multiethnic case-control study.
Authors: Joshi A.D. , Corral R. , Catsburg C. , Lewinger J.P. , Koo J. , John E.M. , Ingles S.A. , Stern M.C. .
Source: Carcinogenesis, 2012 Nov; 33(11), p. 2108-18.
EPub date: 2012-07-20.
PMID: 22822096
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Polymorphisms in carcinogen metabolism enzymes, fish intake, and risk of prostate cancer.
Authors: Catsburg C. , Joshi A.D. , Corral R. , Lewinger J.P. , Koo J. , John E.M. , Ingles S.A. , Stern M.C. .
Source: Carcinogenesis, 2012 Jul; 33(7), p. 1352-9.
EPub date: 2012-05-18.
PMID: 22610071
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Calcium intake and prostate cancer among African Americans: effect modification by vitamin D receptor calcium absorption genotype.
Authors: Rowland G.W. , Schwartz G.G. , John E.M. , Ingles S.A. .
Source: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012 Jan; 27(1), p. 187-94.
PMID: 21887707
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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Authors: Kote-Jarai Z. , Olama A.A. , Giles G.G. , Severi G. , Schleutker J. , Weischer M. , Campa D. , Riboli E. , Key T. , Gronberg H. , et al. .
Source: Nature genetics, 2011-07-10; 43(8), p. 785-91.
EPub date: 2011-07-10.
PMID: 21743467
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Validation of genome-wide prostate cancer associations in men of African descent.
Authors: Chang B.L. , Spangler E. , Gallagher S. , Haiman C.A. , Henderson B. , Isaacs W. , Benford M.L. , Kidd L.R. , Cooney K. , Strom S. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Jan; 20(1), p. 23-32.
EPub date: 2010-11-11.
PMID: 21071540
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Prostate cancer in African-American men and polymorphism in the calcium-sensing receptor.
Authors: Schwartz G.G. , John E.M. , Rowland G. , Ingles S.A. .
Source: Cancer biology & therapy, 2010-06-15; 9(12), p. 994-9.
EPub date: 2010-06-04.
PMID: 20364112
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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
Authors: Eeles R.A. , Kote-Jarai Z. , Al Olama A.A. , Giles G.G. , Guy M. , Severi G. , Muir K. , Hopper J.L. , Henderson B.E. , Haiman C.A. , et al. .
Source: Nature genetics, 2009 Oct; 41(10), p. 1116-21.
EPub date: 2009-09-20.
PMID: 19767753
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Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.
Authors: Kote-Jarai Z. , Easton D.F. , Stanford J.L. , Ostrander E.A. , Schleutker J. , Ingles S.A. , Schaid D. , Thibodeau S. , Dörk T. , Neal D. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Aug; 17(8), p. 2052-61.
PMID: 18708398
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Multiple regions within 8q24 independently affect risk for prostate cancer.
Authors: Haiman C.A. , Patterson N. , Freedman M.L. , Myers S.R. , Pike M.C. , Waliszewska A. , Neubauer J. , Tandon A. , Schirmer C. , McDonald G.J. , et al. .
Source: Nature genetics, 2007 May; 39(5), p. 638-44.
EPub date: 2007-04-01.
PMID: 17401364
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Genetic determinants of serum prostate-specific antigen levels in healthy men from a multiethnic cohort.
Authors: Xue W.M. , Coetzee G.A. , Ross R.K. , Irvine R. , Kolonel L. , Henderson B.E. , Ingles S.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001 Jun; 10(6), p. 575-9.
PMID: 11401905
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