Grant Number:	1R01CA100474-01 Interpret this number
Primary Investigator:	Oeffinger, Kevin
Organization:	Ut Southwestern Medical Center
Project Title:	Project Allife - Exercise and Leukemia Survivors
Fiscal Year:	2003

DESCRIPTION (provided by applicant): Adult survivors of childhood leukemia are a growing population that have an excess in all-cause and cardiovascular (CVD)-related mortality and are at risk for multiple health problems, including CVD, osteoporosis, and obesity. Physical activity is protective and reduces risk for CVD, hypertension, Type 2 diabetes mellitus, and osteoporosis. The Lifestyle Physical Activity intervention has been efficacious in the general population in increasing sustainable levels of moderate-intensity physical activity and cardiorespiratory fitness and improving cardiovascular risk profiles and mental health. A targeted intervention tailored to the needs of leukemia survivors and intended to increase sustainable levels of moderate-intensity physical activity is not only warranted, but critical. It is imperative that methods to reduce morbidity and mortality of this young population while enhancing quality of life and productivity be addressed. The proposed study, Project ALLIFE (Acute Leukemia Lifestyle Intervention For Everyday), is a 12- month effectiveness trial with 120 young adult survivors of childhood leukemia randomized to either the Lifestyle Physical Activity intervention (ALLIFE-I) or a standard control group who will receive a periodic generic health newsletter (ALLIFE-SC). Major data collections will be at baseline, 6- and 12-months, with the two primary outcomes being levels of physical activity, as measured by 7-day physical activity recall, and cardiorespiratory fitness, as measured by the Aerobic Adaptation Test. Secondary outcomes will include other well-established measures of physical activity, cardiovascular risk profiles, gait and balance assessment, and psychological measurements. The primary research hypothesis to be tested is that the Lifestyle intervention will significantly increase physical activity and cardiorespiratory fitness in adult survivors of childhood leukemia in comparison with standard care. Three additional questions to be addressed are: determining if such an intervention leads to improvement in cardiovascular risk profile; determining if gait and balance disturbances are related to physical inactivity in leukemia survivors and if these disturbances improve with the intervention; and identifying factors that are predictive of improvement or lack of improvement in outcomes. This study will represent the first clinical trial aimed at increasing physical activity in leukemia survivors and will advance our understanding of this vulnerable population.




Reduced cardiorespiratory fitness in adult survivors of childhood acute lymphoblastic leukemia.
Authors: Tonorezos E.S. , Snell P.G. , Moskowitz C.S. , Eshelman-Kent D.A. , Liu J.E. , Chou J.F. , Smith S.M. , Dunn A.L. , Church T.S. , Oeffinger K.C. .
Source: Pediatric Blood & Cancer, 2013 Aug; 60(8), p. 1358-64.
PMID: 23418044
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Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia.
Authors: Tonorezos E.S. , Robien K. , Eshelman-Kent D. , Moskowitz C.S. , Church T.S. , Ross R. , Oeffinger K.C. .
Source: Cancer Causes & Control : Ccc, 2013 Feb; 24(2), p. 313-21.
PMID: 23187859
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Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia.
Authors: Malhotra J. , Tonorezos E.S. , Rozenberg M. , Vega G.L. , Sklar C.A. , Chou J. , Moskowitz C.S. , Eshelman-Kent D.A. , Janiszewski P. , Ross R. , et al. .
Source: Journal Of Lipid Research, 2012 Dec; 53(12), p. 2747-54.
PMID: 22984143
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Abdominal radiation and diabetes: one more piece in the puzzle.
Authors: Oeffinger K.C. , Sklar C.A. .
Source: The Lancet. Oncology, 2012 Oct; 13(10), p. 961-2.
PMID: 22921662
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Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia.
Authors: Tonorezos E.S. , Vega G.L. , Sklar C.A. , Chou J.F. , Moskowitz C.S. , Mo Q. , Church T.S. , Ross R. , Janiszewski P.M. , Oeffinger K.C. .
Source: Pediatric Blood & Cancer, 2012 Jan; 58(1), p. 31-6.
PMID: 21254377
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Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia.
Authors: Oeffinger K.C. , Adams-Huet B. , Victor R.G. , Church T.S. , Snell P.G. , Dunn A.L. , Eshelman-Kent D.A. , Ross R. , Janiszewski P.M. , Turoff A.J. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2009-08-01 00:00:00.0; 27(22), p. 3698-704.
EPub date: 2009-08-01 00:00:00.0.
PMID: 19564534
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Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.
Authors: Garmey E.G. , Liu Q. , Sklar C.A. , Meacham L.R. , Mertens A.C. , Stovall M.A. , Yasui Y. , Robison L.L. , Oeffinger K.C. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2008-10-01 00:00:00.0; 26(28), p. 4639-45.
PMID: 18824710
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Are survivors of acute lymphoblastic leukemia (ALL) at increased risk of cardiovascular disease?
Authors: Oeffinger K.C. .
Source: Pediatric Blood & Cancer, 2008 Feb; 50(2 Suppl), p. 462-7; discussion 468.
PMID: 18064658
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Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia.
Authors: Janiszewski P.M. , Oeffinger K.C. , Church T.S. , Dunn A.L. , Eshelman D.A. , Victor R.G. , Brooks S. , Turoff A.J. , Sinclair E. , Murray J.C. , et al. .
Source: The Journal Of Clinical Endocrinology And Metabolism, 2007 Oct; 92(10), p. 3816-21.
PMID: 17652222
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Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study.
Authors: Florin T.A. , Fryer G.E. , Miyoshi T. , Weitzman M. , Mertens A.C. , Hudson M.M. , Sklar C.A. , Emmons K. , Hinkle A. , Whitton J. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2007 Jul; 16(7), p. 1356-63.
PMID: 17627001
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Obesity in pediatric oncology.
Authors: Rogers P.C. , Meacham L.R. , Oeffinger K.C. , Henry D.W. , Lange B.J. .
Source: Pediatric Blood & Cancer, 2005 Dec; 45(7), p. 881-91.
PMID: 16035086
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Long-term complications following childhood and adolescent cancer: foundations for providing risk-based health care for survivors.
Authors: Oeffinger K.C. , Hudson M.M. .
Source: Ca: A Cancer Journal For Clinicians, 2004 Jul-Aug; 54(4), p. 208-36.
PMID: 15253918
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