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Grant Details

Grant Number: 1R03CA097751-01 Interpret this number
Primary Investigator: Haas, Gabriel
Organization: Upstate Medical University
Project Title: Postmortem Psa: Role in Epidemiology of Prostate Cancer
Fiscal Year: 2002
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Abstract

DESCRIPTION (provided by applicant) Validation of postmortem PSA as an accurate reflection of the deceased's actual PSA is a necessary step before major epidemiologic studies can be conducted on cadaver prostates. Our group has extensive experience with the conduct of large scale epidemiologic studies on autopsy specimens and have recently described the prevalence of prostate cancer in young white and African American males. We are initiating a study to evaluate the ability of PSA and its related forms such as free PSA (fPSA), complexed PSA (cPSA), hK2, etc. to detect microscopic, occult malignancies. It is important to characterize the ability of PSA to detect these lesions, because they may need to be diagnosed in young males, whereas they may not be biologically important in elderly men. Unfortunately we can only identify from surgical series those lesions which were already detected by PSA, and do not have knowledge of those tumors which were not identified by PSA (false negative results). This information is better derived from autopsy series, provided postmortem PSA is an accurate reflection of the individual's pre-mortem values. The purpose of the current study is to seek validation of this hypothesis. We propose to evaluate total PSA (tPSA), fPSA, cPSA and hK2 levels in 60 men autopsied at our institution and who have serum samples available from prior to death to analyze for PSA. Blood samples taken prior to death will be compared to PSA measurements on samples obtained at various time points up to 48 hour following death.

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Publications

Association of MnSOD AA Genotype with the Progression of Prostate Cancer.
Authors: Iguchi T. , Wang C.Y. , Delongchamps N.B. , Kato M. , Tamada S. , Yamasaki T. , de la Roza G. , Nakatani T. , Haas G.P. .
Source: PloS one, 2015; 10(7), p. e0131325.
EPub date: 2015-07-06.
PMID: 26147925
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Pathological characteristics of prostate cancer in elderly men.
Authors: Delongchamps N.B. , Wang C.Y. , Chandan V. , Jones R.F. , Threatte G. , Jumbelic M. , de la Roza G. , Haas G.P. .
Source: The Journal of urology, 2009 Sep; 182(3), p. 927-30.
EPub date: 2009-07-17.
PMID: 19616228
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MnSOD genotype and prostate cancer risk as a function of NAT genotype and smoking status.
Authors: Iguchi T. , Sugita S. , Wang C.Y. , Newman N.B. , Nakatani T. , Haas G.P. .
Source: In vivo (Athens, Greece), 2009 Jan-Feb; 23(1), p. 7-12.
PMID: 19368118
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Saturation biopsies on autopsied prostates for detecting and characterizing prostate cancer.
Authors: Delongchamps N.B. , de la Roza G. , Jones R. , Jumbelic M. , Haas G.P. .
Source: BJU international, 2009 Jan; 103(1), p. 49-54.
EPub date: 2008-08-01.
PMID: 18680497
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Diagnostic accuracy of extended biopsies for the staging of microfocal prostate cancers in autopsy specimen.
Authors: Delongchamps N.B. , de la Roza G. , Chandan V. , Jones R. , Threatte G. , Jumbelic M. , Haas G.P. .
Source: Prostate cancer and prostatic diseases, 2009; 12(2), p. 137-42.
EPub date: 2008-07-15.
PMID: 18626509
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Autopsy evaluation of a prostate cancer case treated with brachytherapy.
Authors: Shapiro A. , Shapiro O. , Delongchamps N.B. , Bogart J.A. , Haas G.P. , De la Roza G. , De la Rosa G. .
Source: Anticancer research, 2008 Nov-Dec; 28(6B), p. 3909-12.
PMID: 19192648
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Occult prostate cancer effects the results of case-control studies due to verification bias.
Authors: Iguchi T. , Wang C.Y. , Delongchamps N.B. , Sunheimer R. , Nakatani T. , de la Roza G. , Haas G.P. .
Source: Anticancer research, 2008 Sep-Oct; 28(5B), p. 3007-10.
PMID: 19031947
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Association of prostate cancer and manganese superoxide dismutase AA genotype influenced by presence of occult cancer in control group.
Authors: Iguchi T. , Wang C.Y. , Delongchamps N.B. , Sunheimer R. , Nakatani T. , de la Roza G. , Haas G.P. .
Source: Urology, 2008 Aug; 72(2), p. 238-41; discussion 241-2.
EPub date: 2008-06-24.
PMID: 18571701
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Evaluation of prostatitis in autopsied prostates--is chronic inflammation more associated with benign prostatic hyperplasia or cancer?
Authors: Delongchamps N.B. , de la Roza G. , Chandan V. , Jones R. , Sunheimer R. , Threatte G. , Jumbelic M. , Haas G.P. .
Source: The Journal of urology, 2008 May; 179(5), p. 1736-40.
EPub date: 2008-03-17.
PMID: 18343414
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The worldwide epidemiology of prostate cancer: perspectives from autopsy studies.
Authors: Haas G.P. , Delongchamps N. , Brawley O.W. , Wang C.Y. , de la Roza G. .
Source: The Canadian journal of urology, 2008 Feb; 15(1), p. 3866-71.
PMID: 18304396
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Needle biopsies on autopsy prostates: sensitivity of cancer detection based on true prevalence.
Authors: Haas G.P. , Delongchamps N.B. , Jones R.F. , Chandan V. , Serio A.M. , Vickers A.J. , Jumbelic M. , Threatte G. , Korets R. , Lilja H. , et al. .
Source: Journal of the National Cancer Institute, 2007-10-03; 99(19), p. 1484-9.
EPub date: 2007-09-25.
PMID: 17895474
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Comparison of ante- and post-mortem PSA levels for epidemiological studies.
Authors: Jones R.F. , Sunheimer R. , Friedman H. , Miller D. , Ginsburg R. , Jumbelic M. , Threatte G. , Haas G.P. .
Source: Anticancer research, 2005 Mar-Apr; 25(2B), p. 1263-7.
PMID: 15865076
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