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Grant Details

Grant Number: 5U24CA078174-05 Interpret this number
Primary Investigator: Mineau, Geraldine
Organization: University Of Utah
Project Title: Rocky Mountain Cancer Genetics Coalition
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Applicant's Description) Inherited predispositions to specific cancers due to high penetrance alleles of genes such as APC and BRCA1 account for only a small percentage of our populations cancer burden. Genetic epidemiological evidence suggests, however, that a much higher percentage of individuals may be at risk due to the inheritance of alleles, or combinations of alleles, that individually show only a relatively low cancer penetrance. This makes it difficult to analyze the associated patterns of inheritance, localize the loci and identify the specific genes involved. Large sample populations are now required to map and identify these genes. We propose establishing a consortium consisting of the Universities of Colorado, New Mexico and Utah whose primary purpose will be to enroll a study population and create an infrastructure to support this next generation of exploration of the genetics of cancer. A population-based approach is needed to understand the population significance of future findings. State cancer registries provide an appropriate avenue of ascertainment. It is also important to develop a study population enriched for predisposed individuals. Our approach, therefore, is to ascertain individuals with one or more relatives who have been diagnosed with the specific cancer. Specifically, we propose initially to contact each individual diagnosed with breast, prostate, or colorectal cancer in calendar 1998 and 1999 and determine: 1) whether they are willing to participate and 2) have first-degree relatives affected with their same cancer. If so, they will be recontacted and asked to provide more detailed information regarding family history, as well as demographic and epidemiologic information. Selected index cases will be requested to complete questionnaires, which will include the names of their first-degree relatives and their permission to contact these relatives. The first-degree relatives will then be contacted and invited to enroll as members of the Cancer Genetics Network. This approach will create a study population of family members who have had cancer and who are at risk for cancer. We will also offer enrollment to appropriate individuals who have already contacted our high-risk clinics or are enrolled in ongoing clinical protocols of familial cancer; for example, Colorado will extend their current research interests by collecting lung cases. In addition, we will establish or enhance clinical and laboratory core facilities, as well as the necessary capabilities in genetic counseling, informatics and database management. As study groups are enrolled, DNA samples may be collected and pilot projects initiated; these include sib-pair studies and candidate-gene analysis funded by the Huntsman Cancer Institute and the University of Colorado Cancer Center.

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Publications

Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials.
Authors: Skates S.J. , Greene M.H. , Buys S.S. , Mai P.L. , Brown P. , Piedmonte M. , Rodriguez G. , Schorge J.O. , Sherman M. , Daly M.B. , et al. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2017-07-15; 23(14), p. 3628-3637.
EPub date: 2017-01-31.
PMID: 28143870
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Long-term risk of medical conditions associated with breast cancer treatment.
Authors: Hill D.A. , Horick N.K. , Isaacs C. , Domchek S.M. , Tomlinson G.E. , Lowery J.T. , Kinney A.Y. , Berg J.S. , Edwards K.L. , Moorman P.G. , et al. .
Source: Breast cancer research and treatment, 2014 May; 145(1), p. 233-43.
EPub date: 2014-04-03.
PMID: 24696430
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A randomized trial to increase colonoscopy screening in members of high-risk families in the colorectal cancer family registry and cancer genetics network.
Authors: Lowery J.T. , Horick N. , Kinney A.Y. , Finkelstein D.M. , Garrett K. , Haile R.W. , Lindor N.M. , Newcomb P.A. , Sandler R.S. , Burke C. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014 Apr; 23(4), p. 601-10.
EPub date: 2014-02-05.
PMID: 24501379
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Activating mutation in MET oncogene in familial colorectal cancer.
Authors: Neklason D.W. , Done M.W. , Sargent N.R. , Schwartz A.G. , Anton-Culver H. , Griffin C.A. , Ahnen D.J. , Schildkraut J.M. , Tomlinson G.E. , Strong L.C. , et al. .
Source: BMC cancer, 2011-10-04; 11, p. 424.
EPub date: 2011-10-04.
PMID: 21970370
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Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status.
Authors: Skates S.J. , Mai P. , Horick N.K. , Piedmonte M. , Drescher C.W. , Isaacs C. , Armstrong D.K. , Buys S.S. , Rodriguez G.C. , Horowitz I.R. , et al. .
Source: Cancer prevention research (Philadelphia, Pa.), 2011 Sep; 4(9), p. 1401-8.
PMID: 21893500
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Differential expression of prognostic biomarkers between interval and screen-detected breast cancers: does age or family history matter?
Authors: Lowery J.T. , Byers T. , Kittelson J. , Hokanson J.E. , Mouchawar J. , Lewin J. , Merrick D. , Hines L. , Singh M. .
Source: Breast cancer research and treatment, 2011 Aug; 129(1), p. 211-9.
EPub date: 2011-03-24.
PMID: 21431872
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Clinically relevant changes in family history of cancer over time.
Authors: Ziogas A. , Horick N.K. , Kinney A.Y. , Lowery J.T. , Domchek S.M. , Isaacs C. , Griffin C.A. , Moorman P.G. , Edwards K.L. , Hill D.A. , et al. .
Source: JAMA, 2011-07-13; 306(2), p. 172-8.
PMID: 21750294
Related Citations

The impact of direct-to-consumer marketing of cancer genetic testing on women according to their genetic risk.
Authors: Lowery J.T. , Byers T. , Axell L. , Ku L. , Jacobellis J. .
Source: Genetics in medicine : official journal of the American College of Medical Genetics, 2008 Dec; 10(12), p. 888-94.
PMID: 19092441
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Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis.
Authors: Neklason D.W. , Kerber R.A. , Nilson D.B. , Anton-Culver H. , Schwartz A.G. , Griffin C.A. , Lowery J.T. , Schildkraut J.M. , Evans J.P. , Tomlinson G.E. , et al. .
Source: Cancer research, 2008-11-01; 68(21), p. 8993-7.
PMID: 18974144
Related Citations

Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
Authors: Kerber R.A. , Amos C.I. , Yeap B.Y. , Finkelstein D.M. , Thomas D.C. .
Source: BMC medical genetics, 2008-07-10; 9, p. 64.
EPub date: 2008-07-10.
PMID: 18616822
Related Citations

What do cancer survivors believe causes cancer? (United States).
Authors: Wold K.S. , Byers T. , Crane L.A. , Ahnen D. .
Source: Cancer causes & control : CCC, 2005 Mar; 16(2), p. 115-23.
PMID: 15868453
Related Citations

Ethical issues in identifying and recruiting participants for familial genetic research.
Authors: Beskow L.M. , Botkin J.R. , Daly M. , Juengst E.T. , Lehmann L.S. , Merz J.F. , Pentz R. , Press N.A. , Ross L.F. , Sugarman J. , et al. .
Source: American journal of medical genetics. Part A, 2004-11-01; 130A(4), p. 424-31.
PMID: 15455364
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A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function.
Authors: Kokontis J.M. , Wagner A.J. , O'Leary M. , Liao S. , Hay N. .
Source: Oncogene, 2001-02-08; 20(6), p. 659-68.
PMID: 11313999
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