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Grant Details

Grant Number: 5U24CA078164-05 Interpret this number
Primary Investigator: Bowen, Deborah
Organization: Fred Hutchinson Cancer Research Center
Project Title: Northwest Cancer Genetics Network
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Applicant's Description) The Northwest Cancer Genetics Network (NWCGN) - proposed in response to the Cancer Genetics Network (RFA #97004) - will be a resource for studies of the genetic basis of cancer susceptibility, the appropriate use of this information in medical practice, and the impact of knowledge of cancer genetics on public health. To accomplish these aims, we will 1) participate in the development and management of the CGN and 2) will contribute to the CGN a register of individuals interested in cancer screening and/or at defined levels of risk for cancer. The primary focus will be on individuals interested in genetic testing identified from the area genetic clinics (including an existing network in which we participate), via physicians and as self-referrals. In order to ensure representative and efficient recruitment of high-risk individuals, a population-based registry will be established for probands with diagnoses of specific cancers, their family members, and a population sample. All participants will complete a structured interview on family history of cancer, medical history, and other factors thought to influence cancer risk. All participants will be provided individualized risk information. The NWCGN brings to the CGN significant expertise in clinical genetics, molecular genetics, molecular biology, epidemiology, biostatistics, economics, ethics, counseling, primary care and psychology. This mix of disciplines is essential to support the infrastructure required to collect crucial data on individuals seeking genetic testing, as well as those with known family histories.

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Publications

Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials.
Authors: Skates S.J. , Greene M.H. , Buys S.S. , Mai P.L. , Brown P. , Piedmonte M. , Rodriguez G. , Schorge J.O. , Sherman M. , Daly M.B. , et al. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2017-07-15; 23(14), p. 3628-3637.
EPub date: 2017-01-31.
PMID: 28143870
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Long-term risk of medical conditions associated with breast cancer treatment.
Authors: Hill D.A. , Horick N.K. , Isaacs C. , Domchek S.M. , Tomlinson G.E. , Lowery J.T. , Kinney A.Y. , Berg J.S. , Edwards K.L. , Moorman P.G. , et al. .
Source: Breast cancer research and treatment, 2014 May; 145(1), p. 233-43.
EPub date: 2014-04-03.
PMID: 24696430
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A randomized trial to increase colonoscopy screening in members of high-risk families in the colorectal cancer family registry and cancer genetics network.
Authors: Lowery J.T. , Horick N. , Kinney A.Y. , Finkelstein D.M. , Garrett K. , Haile R.W. , Lindor N.M. , Newcomb P.A. , Sandler R.S. , Burke C. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014 Apr; 23(4), p. 601-10.
EPub date: 2014-02-05.
PMID: 24501379
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Awareness and uptake of direct-to-consumer genetic testing among cancer cases, their relatives, and controls: the Northwest Cancer Genetics Network.
Authors: Hall T.O. , Renz A.D. , Snapinn K.W. , Bowen D.J. , Edwards K.L. .
Source: Genetic testing and molecular biomarkers, 2012 Jul; 16(7), p. 744-8.
EPub date: 2012-06-25.
PMID: 22731649
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Predictors of recruited melanoma families into a behavioral intervention project.
Authors: Bowen D.J. , Hay J.L. , Mayer J. , Kuniyuki A. , Meischke H. , Harris J. , Asgari M. , Shoveller J. , Press N. , Burke W. .
Source: Contemporary clinical trials, 2012 Jan; 33(1), p. 85-92.
EPub date: 2011-10-08.
PMID: 22001361
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Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status.
Authors: Skates S.J. , Mai P. , Horick N.K. , Piedmonte M. , Drescher C.W. , Isaacs C. , Armstrong D.K. , Buys S.S. , Rodriguez G.C. , Horowitz I.R. , et al. .
Source: Cancer prevention research (Philadelphia, Pa.), 2011 Sep; 4(9), p. 1401-8.
PMID: 21893500
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Clinically relevant changes in family history of cancer over time.
Authors: Ziogas A. , Horick N.K. , Kinney A.Y. , Lowery J.T. , Domchek S.M. , Isaacs C. , Griffin C.A. , Moorman P.G. , Edwards K.L. , Hill D.A. , et al. .
Source: JAMA, 2011-07-13; 306(2), p. 172-8.
PMID: 21750294
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Future health applications of genomics: priorities for communication, behavioral, and social sciences research.
Authors: McBride C.M. , Bowen D. , Brody L.C. , Condit C.M. , Croyle R.T. , Gwinn M. , Khoury M.J. , Koehly L.M. , Korf B.R. , Marteau T.M. , et al. .
Source: American journal of preventive medicine, 2010 May; 38(5), p. 556-65.
PMID: 20409503
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Influence of ovarian cancer risk status on the diagnostic performance of the serum biomarkers mesothelin, HE4, and CA125.
Authors: Shah C.A. , Lowe K.A. , Paley P. , Wallace E. , Anderson G.L. , McIntosh M.W. , Andersen M.R. , Scholler N. , Bergan L.A. , Thorpe J.D. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009 May; 18(5), p. 1365-72.
PMID: 19423517
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Predictors of self-referral into a cancer genetics registry.
Authors: Henrikson N.B. , Harris J.N. , Bowen D.J. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007 Jul; 16(7), p. 1387-92.
PMID: 17627003
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What do we mean by Internet access? A framework for health researchers.
Authors: Bush N.E. , Bowen D.J. , Wooldridge J. , Ludwig A. , Meischke H. , Robbins R. .
Source: Preventing chronic disease, 2004 Oct; 1(4), p. A15.
EPub date: 2004-09-15.
PMID: 15670447
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Marsupial BRCA1: conserved regions in mammals and the potential effect of missense changes.
Authors: Ramirez C.J. , Fleming M.A. , Potter J.D. , Ostrander G.K. , Ostrander E.A. .
Source: Oncogene, 2004-03-04; 23(9), p. 1780-8.
PMID: 15001988
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Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma-pancreatic carcinoma syndrome.
Authors: Rulyak S.J. , Brentnall T.A. , Lynch H.T. , Austin M.A. .
Source: Cancer, 2003-08-15; 98(4), p. 798-804.
PMID: 12910525
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Understanding missense mutations in the BRCA1 gene: an evolutionary approach.
Authors: Fleming M.A. , Potter J.D. , Ramirez C.J. , Ostrander G.K. , Ostrander E.A. .
Source: Proceedings of the National Academy of Sciences of the United States of America, 2003-02-04; 100(3), p. 1151-6.
EPub date: 2003-01-16.
PMID: 12531920
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Achieving utility with family history: colorectal cancer risk.
Authors: Bowen D.J. , Ludman E. , Press N. , Vu T. , Burke W. .
Source: American journal of preventive medicine, 2003 Feb; 24(2), p. 177-82.
PMID: 12568824
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