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Grant Details

Grant Number: 5U24CA078146-05 Interpret this number
Primary Investigator: Isaacs, Claudine
Organization: Georgetown University
Project Title: Cancer Genetics Network
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Applicant's Description) While advances in cancer genetics are occurring at rapid pace, critical questions about genetic susceptibility and prevention remain unanswered. In response to the RFA for the Cancer Genetics Network, we propose to: (1) Enroll substantial numbers of the following populations into the CGN: (a) hereditary breast, ovarian, and colon cancer families, (b) newly diagnosed high risk breast cancer patients, and (c) persons at low to moderate risk of cancer; (2) Utilize our existing networks of community-based hospitals and primary care clinics to increase CGN enrollment of African Americans and Latin Americans in the Washington, D.C. area; (3) Contribute our well-validated IRB-approved protocols for informed consent, pre-test education, and genetic counseling to the CGN; (4) Provide CGN investigators with access to our state-of-the-art laboratory technologies for diagnostic genetic analysis; (5) Utilize our existing infrastructure for cancer DNA/tissue collection, processing, and storage to contribute to basic cancer genetics research in the CGN; (6) Modify existing cancer genetics educational materials to target African Americans and develop Spanish language materials, consent forms and counseling protocols for use with Latin Americans; (7) Provide genetics education and training programs for a wide range of healthcare providers, including nurses and medical students; and (8) Contribute our expertise conducting research on the clinical, psychosocial, and economic outcomes of genetic testing for cancer susceptibility.

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Publications

Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials.
Authors: Skates S.J. , Greene M.H. , Buys S.S. , Mai P.L. , Brown P. , Piedmonte M. , Rodriguez G. , Schorge J.O. , Sherman M. , Daly M.B. , et al. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2017-07-15; 23(14), p. 3628-3637.
EPub date: 2017-01-31.
PMID: 28143870
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Long-term risk of medical conditions associated with breast cancer treatment.
Authors: Hill D.A. , Horick N.K. , Isaacs C. , Domchek S.M. , Tomlinson G.E. , Lowery J.T. , Kinney A.Y. , Berg J.S. , Edwards K.L. , Moorman P.G. , et al. .
Source: Breast cancer research and treatment, 2014 May; 145(1), p. 233-43.
EPub date: 2014-04-03.
PMID: 24696430
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BRCA mutation testing in determining breast cancer therapy.
Authors: Smith K.L. , Isaacs C. .
Source: Cancer journal (Sudbury, Mass.), 2011 Nov-Dec; 17(6), p. 492-9.
PMID: 22157293
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Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status.
Authors: Skates S.J. , Mai P. , Horick N.K. , Piedmonte M. , Drescher C.W. , Isaacs C. , Armstrong D.K. , Buys S.S. , Rodriguez G.C. , Horowitz I.R. , et al. .
Source: Cancer prevention research (Philadelphia, Pa.), 2011 Sep; 4(9), p. 1401-8.
PMID: 21893500
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Clinically relevant changes in family history of cancer over time.
Authors: Ziogas A. , Horick N.K. , Kinney A.Y. , Lowery J.T. , Domchek S.M. , Isaacs C. , Griffin C.A. , Moorman P.G. , Edwards K.L. , Hill D.A. , et al. .
Source: JAMA, 2011-07-13; 306(2), p. 172-8.
PMID: 21750294
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Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study.
Authors: Lehman C.D. , Isaacs C. , Schnall M.D. , Pisano E.D. , Ascher S.M. , Weatherall P.T. , Bluemke D.A. , Bowen D.J. , Marcom P.K. , Armstrong D.K. , et al. .
Source: Radiology, 2007 Aug; 244(2), p. 381-8.
PMID: 17641362
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Characterization of BRCA1 and BRCA2 mutations in a large United States sample.
Authors: Chen S. , Iversen E.S. , Friebel T. , Finkelstein D. , Weber B.L. , Eisen A. , Peterson L.E. , Schildkraut J.M. , Isaacs C. , Peshkin B.N. , et al. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-02-20; 24(6), p. 863-71.
PMID: 16484695
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Tamoxifen as chemoprevention in BRCA1 and BRCA2 mutation carriers with breast cancer: a pilot survey of physicians.
Authors: Peshkin B.N. , Isaacs C. , Finch C. , Kent S. , Schwartz M.D. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003-12-01; 21(23), p. 4322-8.
PMID: 14645421
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