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Grant Details

Grant Number: 5U01CA082004-04 Interpret this number
Primary Investigator: Remington, Patrick
Organization: University Of Wisconsin Madison
Project Title: Regional Variation of Breast Cancer Rates in Wisconsin
Fiscal Year: 2002
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Abstract

We propose conducting a population-based study to explain the regional variation in breast cancer rates in Wisconsin that will build upon past and ongoing case-control studies of breast cancer at the University of Wisconsin Comprehensive Cancer Center. We hypothesize that the regional variations in breast cancer rates in Wisconsin are due to regional variations in established or potential breast cancer risk factors. The specific aims include 1) comparing breast cancer incidence, mortality, and survival rates within Wisconsin by geographic area; 2) evaluating the contribution of previously identified breast cancer risk factors, socioeconomic status, and screening practices to the regional variations in breast cancer rates; and 3) evaluating the association between environmental exposures (such as PCBs, DDT, and other xenoestrogens) and breast cancer risk, and if associated, the contribution of these exposures to the regional variations in breast cancer rates. In Phase I, we assign a "geographic breast cancer risk" to every case and control already enrolled in our case-control studies (n=14,000) by analyzing breast cancer mortality and incidence rates by area of residence (county, city, zip code, and census tract). Next, we will adjust this risk by controlling for established and potential individual-and community-level risk factors for breast cancer. In Phase II, we will expand our ongoing case-control study (n=6,600) by collecting information on environmental exposures and determining their contribution to the regional variation in breast cancer rates. Biologic specimen collection currently (buccal smears) and proposed (blood) will enable us to evaluate genetic risk and markers of biologic exposure. By utilizing existing populations, protocols, personnel, and software, we can complete these evaluations in an efficient, timely, and statistically valid manner. This approach will enable us, in collaboration with the NCI, NIEHS, and other funded researchers, to examine in detail the contribution of a variety of individual- and community-level exposures to the long-standing regional variation in breast cancer rates in Wisconsin and will improve our understanding of the causes of breast cancer.

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Publications

Cigarette Smoking Before and After Breast Cancer Diagnosis: Mortality From Breast Cancer and Smoking-Related Diseases.
Authors: Passarelli M.N. , Newcomb P.A. , Hampton J.M. , Trentham-Dietz A. , Titus L.J. , Egan K.M. , Baron J.A. , Willett W.C. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-04-20; 34(12), p. 1315-22.
EPub date: 2016-01-25.
PMID: 26811527
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Variation in Breast Cancer-Risk Factor Associations by Method of Detection: Results From a Series of Case-Control Studies.
Authors: Sprague B.L. , Gangnon R.E. , Hampton J.M. , Egan K.M. , Titus L.J. , Kerlikowske K. , Remington P.L. , Newcomb P.A. , Trentham-Dietz A. .
Source: American journal of epidemiology, 2015-06-15; 181(12), p. 956-69.
EPub date: 2015-05-05.
PMID: 25944893
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Modification of breast cancer risk according to age and menopausal status: a combined analysis of five population-based case-control studies.
Authors: Trentham-Dietz A. , Sprague B.L. , Hampton J.M. , Miglioretti D.L. , Nelson H.D. , Titus L.J. , Egan K.M. , Remington P.L. , Newcomb P.A. .
Source: Breast cancer research and treatment, 2014 May; 145(1), p. 165-75.
EPub date: 2014-03-20.
PMID: 24647890
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Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes.
Authors: Newcomb P.A. , Kampman E. , Trentham-Dietz A. , Egan K.M. , Titus L.J. , Baron J.A. , Hampton J.M. , Passarelli M.N. , Willett W.C. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-06-01; 31(16), p. 1939-46.
EPub date: 2013-04-08.
PMID: 23569314
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Breast cancer susceptibility associated with rs1219648 (fibroblast growth factor receptor 2) and postmenopausal hormone therapy use in a population-based United States study.
Authors: Andersen S.W. , Trentham-Dietz A. , Figueroa J.D. , Titus L.J. , Cai Q. , Long J. , Hampton J.M. , Egan K.M. , Newcomb P.A. .
Source: Menopause (New York, N.Y.), 2013 Mar; 20(3), p. 354-8.
PMID: 23435034
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Reproductive factors and histologic subtype in relation to mortality after a breast cancer diagnosis.
Authors: Warren Andersen S. , Newcomb P.A. , Hampton J.M. , Titus-Ernstoff L. , Egan K.M. , Trentham-Dietz A. .
Source: Breast cancer research and treatment, 2011 Dec; 130(3), p. 975-80.
EPub date: 2011-07-19.
PMID: 21769659
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Late age at first full term birth is strongly associated with lobular breast cancer.
Authors: Newcomb P.A. , Trentham-Dietz A. , Hampton J.M. , Egan K.M. , Titus-Ernstoff L. , Warren Andersen S. , Greenberg E.R. , Willett W.C. .
Source: Cancer, 2011-05-01; 117(9), p. 1946-56.
EPub date: 2010-11-10.
PMID: 21509772
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Socioeconomic status and survival after an invasive breast cancer diagnosis.
Authors: Sprague B.L. , Trentham-Dietz A. , Gangnon R.E. , Ramchandani R. , Hampton J.M. , Robert S.A. , Remington P.L. , Newcomb P.A. .
Source: Cancer, 2011-04-01; 117(7), p. 1542-51.
EPub date: 2010-11-08.
PMID: 21425155
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Local multiplicity adjustments for spatial cluster detection.
Authors: Gangnon R.E. .
Source: Environmental and ecological statistics, 2010; 17(1), p. 55-71.
PMID: 20485455
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Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.
Authors: Samuelson D.J. , Hesselson S.E. , Aperavich B.A. , Zan Y. , Haag J.D. , Trentham-Dietz A. , Hampton J.M. , Mau B. , Chen K.S. , Baynes C. , et al. .
Source: Proceedings of the National Academy of Sciences of the United States of America, 2007-04-10; 104(15), p. 6299-304.
EPub date: 2007-04-02.
PMID: 17404222
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Impact of prior choice on local Bayes factors for cluster detection.
Authors: Gangnon R.E. .
Source: Statistics in medicine, 2006-03-15; 25(5), p. 883-95.
PMID: 16453368
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The Wisconsin Breast Cancer Epidemiology Simulation Model.
Authors: Fryback D.G. , Stout N.K. , Rosenberg M.A. , Trentham-Dietz A. , Kuruchittham V. , Remington P.L. .
Source: Journal of the National Cancer Institute. Monographs, 2006; (36), p. 37-47.
PMID: 17032893
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Identifying geographic disparities in the early detection of breast cancer using a geographic information system.
Authors: McElroy J.A. , Remington P.L. , Gangnon R.E. , Hariharan L. , Andersen L.D. .
Source: Preventing chronic disease, 2006 Jan; 3(1), p. A10.
EPub date: 2005-12-15.
PMID: 16356363
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A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer.
Authors: Nelson S.E. , Gould M.N. , Hampton J.M. , Trentham-Dietz A. .
Source: Breast cancer research : BCR, 2005; 7(3), p. R357-64.
EPub date: 2005-03-11.
PMID: 15987431
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Socioeconomic risk factors for breast cancer: distinguishing individual- and community-level effects.
Authors: Robert S.A. , Strombom I. , Trentham-Dietz A. , Hampton J.M. , McElroy J.A. , Newcomb P.A. , Remington P.L. .
Source: Epidemiology (Cambridge, Mass.), 2004 Jul; 15(4), p. 442-50.
PMID: 15232405
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Potential exposure to PCBs, DDT, and PBDEs from sport-caught fish consumption in relation to breast cancer risk in Wisconsin.
Authors: McElroy J.A. , Kanarek M.S. , Trentham-Dietz A. , Robert S.A. , Hampton J.M. , Newcomb P.A. , Anderson H.A. , Remington P.L. .
Source: Environmental health perspectives, 2004 Feb; 112(2), p. 156-62.
PMID: 14754569
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Community trends in the early detection of breast cancer in Wisconsin, 1980-1998.
Authors: Andersen L.D. , Remington P.L. , Trentham-Dietz A. , Robert S. .
Source: American journal of preventive medicine, 2004 Jan; 26(1), p. 51-5.
PMID: 14700713
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Geocoding addresses from a large population-based study: lessons learned.
Authors: McElroy J.A. , Remington P.L. , Trentham-Dietz A. , Robert S.A. , Newcomb P.A. .
Source: Epidemiology (Cambridge, Mass.), 2003 Jul; 14(4), p. 399-407.
PMID: 12843762
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Assessing a decade of progress in cancer control.
Authors: Andersen L.D. , Remington P. , Trentham-Dietz A. , Reeves M. .
Source: The oncologist, 2002; 7(3), p. 200-4.
PMID: 12065791
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