||5R44CA083451-03 Interpret this number
||Personal Improvement Computer Systems
||Computerized Sgr for Smoking Reduction
DESCRIPTION (provided by investigator): The overall goal of this project is to
continue development and evaluation of a self-help behavioral smoking reduction
program for chronic smokers. The program, LifeSign for Smoking Reduction
(LS-SR), is targeted to chronic smokers who are unwilling to quit smoking, and
for whom a reduction in smoking is a reasonable short-term goal. In Phase I, we
developed a prototype of the LS-SR program that used scheduled gradual
reduction principles to reduce smoking by 50 percent and maintain these
reductions, successfully recruited 99 smokers appropriate for a smoking
reduction intervention, and assessed the feasibility of this prototype in a
randomized controlled trial comparing LS-SR to a manually-guided research
trial. The LS-SR condition produced greater, frequently significantly greater
reductions, in various measures of smoking behavior, dependence, and nicotine
exposure. For Phase II, we propose to modify the LS-SR program based on the
Phase I results and compare this programs to a manually-based smoking reduction
condition in 375 smokers who are not amenable to quitting smoking. Subjects
will be randomly assigned to one of these self-help interventions and will be
assessed at pre-intervention, at post-intervention 7 weeks later and at 14 and
28 weeks post-interventions. The primary outcome measure for the study will be
7 day reconstruction of daily smoking rate corroborated by CO and saliva
cotinine assessment. CO and measures of short-term changes in health status
(e.g. BP, and exertion, health status questionnaire.) Physical fitness will be
measured at all assessment points. To determine the effect of smoking reduction
on subsequent quit attempts, reported quit attempts, methods of quitting, and
periods of abstinence (biochemically validated) as well as self-efficacy to
quit and Stages of Change will be assessed at all visits. Additionally,
measures of smoking typography will be obtained to measure directly the degree
of compensatory smoking resulting from reduced smoking.
PROPOSED COMMERCIAL APPLICATION:
Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers.
, Hanson K.
, Hecht S.S.
, Lindgren B.R.
, Luo X.
, Carmella S.G.
, Riley W.T.
, Zylla E.B.
, Murphy S.E.
, Hatsukami D.K.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Dec; 17(12), p. 3337-43.
Computer and manual self-help behavioral strategies for smoking reduction: initial feasibility and one-year follow-up.
, Jerome A.
, Behar A.
, Weil J.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2002; 4 Suppl 2, p. S183-8.