DESCRIPTION (provided by Applicant)
Pancreatic cancer is the ninth most commonly occurring cancer, but the fifth
leading cause of cancer death in the US. It is one of the most rapidly fatal
cancers, with 1- and 5-year survival of only 16 percent and 0.4 percent. As
there are currently no effective treatments for this disease, prevention is of
paramount importance. Only older age and cigarette smoking are well-
established risk factors. The roles of other risk factors, such as pipe and
cigar smoking, coffee, tea and alcohol consumption, the presence of diabetes
mellitus, and physical activity are unclear.
To provide more information, we propose to analyze the associations of these
characteristics with pancreatic cancer risk using previously collected data.
In 1962 or 1966 (1962/1966), 29,347 men and women, who were free of cancer and
aged 30-79 years, returned a health questionnaire. Subjects also returned
another health questionnaire in 1977. They provided a wide range of
information on these two questionnaires, including data on cigarette, pipe and
cigar smoking, coffee, tea and alcohol consumption, physician-diagnosed
diabetes mellitus, and physical activity. Between 1962/1966 through 1993, 210
subjects died from pancreatic cancer. We request funds to collect another two
years of mortality data through 1995 (given the costs constraints of the small
grants program), bringing the total of pancreatic cancer deaths to an
estimated 230. Power calculations show adequate power to detect moderate
increases in relative risks (1.5-2.5) associated with these risk factors.
This large database provides a unique and cost-effective opportunity to
examine the associations of various characteristics, most of which are
modifiable, with pancreatic cancer risk. Findings from these analyses will
have public health significance for a highly fatal disease.
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- The DCCPS Team.