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Grant Details

Grant Number: 5R01CA087696-03 Interpret this number
Primary Investigator: Cummings, K
Organization: Roswell Park Cancer Institute Corp
Project Title: Internal Council for Tobacco Research and Tobacco Instit
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Applicant's Description) Within the 'Marketing Tobacco to Youth:Evidence from Corporate Documents' study, we have developed a system for indexing and abstracting the tobacco industry documents, a system now being adopted by similar initiatives worldwide. Presently, we have processed approximately 6,000 tobacco industry documents and have made them available for public research through a searchable Internet database at http://www.tobaccodocuments.org. This database offers full subject access and comprehensive abstracts to facilitate research of the tobacco industry documents. In early 1999, the Council for Tobacco Research was subjected to corporate dissolution as a result of the Minnesota Settlement Agreement. Its internal documents, under the authority of the New York State Attorney General's Office, have been transferred to the New York State Archives (NYSA); as have the files of The Tobacco Institute (TI). These documents are not included in the Minnesota Depository and are only accessible through the Archives in Albany, N.Y. NYSA has been charged with developing a plan for permanent storage and public access of the documents. It is strongly anticipated that the CTR and TI files contain fIrst-hand information regarding the tobacco industry's research and development activities, promotional and legal strategies and once confidential attorney-client files outlining the industry's plan of action against proposed regulatory measures. Unfortunately, the CTR and TI records are currently unindexed, preventing meaningful access to the collection. With neither subject access nor comprehensive abstracts, the value of these collections as a research tool for the public health community is significantly reduced. This proposal outlines a plan to assist the New York State Archives in meeting its charge of making the CTR and TI documents publicly accessible in a fully-indexed and abstracted format. Our collaboration with the New York State Archives will no doubt stimulate additional tobacco-related research. Additionally, as part of this project, we will index and abstract approximately one third of the Bliley collection of industry documents (Tobacco Institute, Lorillard and Philip Morris documents), and collaborate with additional public health researchers to index, abstract and evaluate the industry documents related to packaging and pricing strategies. We strongly anticipate that this collaboration will shed new light on I) the industry's efforts at circumventing excise taxes, and 2) methods employed by the industry to promote tobacco products through packaging. We anticipate that this information will assist policy makers in evaluating current regulatory measures to curtail tobacco usage.

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Publications

Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.
Authors: Buckley M.A. , Woods N.T. , Tyrer J.P. , Mendoza-Fandiño G. , Lawrenson K. , Hazelett D.J. , Najafabadi H.S. , Gjyshi A. , Carvalho R.S. , Lyra P.C. , et al. .
Source: Cancer research, 2019-02-01; 79(3), p. 467-481.
EPub date: 2018-11-28.
PMID: 30487138
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Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.
Authors: Kar S.P. , Adler E. , Tyrer J. , Hazelett D. , Anton-Culver H. , Bandera E.V. , Beckmann M.W. , Berchuck A. , Bogdanova N. , Brinton L. , et al. .
Source: British journal of cancer, 2017-02-14; 116(4), p. 524-535.
EPub date: 2017-01-19.
PMID: 28103614
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Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
Authors: Hampras S.S. , Sucheston-Campbell L.E. , Cannioto R. , Chang-Claude J. , Modugno F. , Dörk T. , Hillemanns P. , Preus L. , Knutson K.L. , Wallace P.K. , et al. .
Source: Oncotarget, 2016-10-25; 7(43), p. 69097-69110.
PMID: 27533245
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Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
Authors: Lawrenson K. , Kar S. , McCue K. , Kuchenbaeker K. , Michailidou K. , Tyrer J. , Beesley J. , Ramus S.J. , Li Q. , Delgado M.K. , et al. .
Source: Nature communications, 2016-09-07; 7, p. 12675.
EPub date: 2016-09-07.
PMID: 27601076
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Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.
Authors: Permuth J.B. , Pirie A. , Ann Chen Y. , Lin H.Y. , Reid B.M. , Chen Z. , Monteiro A. , Dennis J. , Mendoza-Fandino G. , AOCS Study Group , et al. .
Source: Human molecular genetics, 2016-08-15; 25(16), p. 3600-3612.
EPub date: 2016-07-04.
PMID: 27378695
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A targeted genetic association study of epithelial ovarian cancer susceptibility.
Authors: Earp M. , Winham S.J. , Larson N. , Permuth J.B. , Sicotte H. , Chien J. , Anton-Culver H. , Bandera E.V. , Berchuck A. , Cook L.S. , et al. .
Source: Oncotarget, 2016-02-16; 7(7), p. 7381-9.
PMID: 26848776
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Evidence of a genetic link between endometriosis and ovarian cancer.
Authors: Lee A.W. , Templeman C. , Stram D.A. , Beesley J. , Tyrer J. , Berchuck A. , Pharoah P.P. , Chenevix-Trench G. , Pearce C.L. , Ovarian Cancer Association Consortium .
Source: Fertility and sterility, 2016 Jan; 105(1), p. 35-43.e1-10.
EPub date: 2015-10-23.
PMID: 26477498
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Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.
Authors: Amankwah E.K. , Lin H.Y. , Tyrer J.P. , Lawrenson K. , Dennis J. , Chornokur G. , Aben K.K. , Anton-Culver H. , Antonenkova N. , Bruinsma F. , et al. .
Source: Genetic epidemiology, 2015 Dec; 39(8), p. 689-97.
EPub date: 2015-09-24.
PMID: 26399219
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Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.
Authors: Lu Y. , Cuellar-Partida G. , Painter J.N. , Nyholt D.R. , Australian Ovarian Cancer Study , International Endogene Consortium (IEC) , Morris A.P. , Fasching P.A. , Hein A. , Burghaus S. , et al. .
Source: Human molecular genetics, 2015-10-15; 24(20), p. 5955-64.
EPub date: 2015-07-30.
PMID: 26231222
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Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.
Authors: Kar S.P. , Tyrer J.P. , Li Q. , Lawrenson K. , Aben K.K. , Anton-Culver H. , Antonenkova N. , Chenevix-Trench G. , Australian Cancer Study , Australian Ovarian Cancer Study Group , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015 Oct; 24(10), p. 1574-84.
EPub date: 2015-07-24.
PMID: 26209509
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Genome-wide significant risk associations for mucinous ovarian carcinoma.
Authors: Kelemen L.E. , Lawrenson K. , Tyrer J. , Li Q. , Lee J.M. , Seo J.H. , Phelan C.M. , Beesley J. , Chen X. , Spindler T.J. , et al. .
Source: Nature genetics, 2015 Aug; 47(8), p. 888-97.
EPub date: 2015-06-15.
PMID: 26075790
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Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.
Authors: Lee A.W. , Tyrer J.P. , Doherty J.A. , Stram D.A. , Kupryjanczyk J. , Dansonka-Mieszkowska A. , Plisiecka-Halasa J. , Spiewankiewicz B. , Myers E.J. , Australian Cancer Study (Ovarian Cancer) , et al. .
Source: Gynecologic oncology, 2015 Mar; 136(3), p. 542-8.
EPub date: 2014-12-17.
PMID: 25528498
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Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).
Authors: Jim H.S. , Lin H.Y. , Tyrer J.P. , Lawrenson K. , Dennis J. , Chornokur G. , Chen Z. , Chen A.Y. , Permuth-Wey J. , Aben K.K. , et al. .
Source: Journal of genetics and genome research, 2015; 2(2), .
EPub date: 2015-09-15.
PMID: 26807442
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Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.
Authors: Chornokur G. , Lin H.Y. , Tyrer J.P. , Lawrenson K. , Dennis J. , Amankwah E.K. , Qu X. , Tsai Y.Y. , Jim H.S. , Chen Z. , et al. .
Source: PloS one, 2015; 10(6), p. e0128106.
EPub date: 2015-06-19.
PMID: 26091520
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Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.
Authors: Kelemen L.E. , Terry K.L. , Goodman M.T. , Webb P.M. , Bandera E.V. , McGuire V. , Rossing M.A. , Wang Q. , Dicks E. , Tyrer J.P. , et al. .
Source: Molecular nutrition & food research, 2014 Oct; 58(10), p. 2023-35.
EPub date: 2014-07-28.
PMID: 25066213
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Variation in NF-κB signaling pathways and survival in invasive epithelial ovarian cancer.
Authors: Block M.S. , Charbonneau B. , Vierkant R.A. , Fogarty Z. , Bamlet W.R. , Pharoah P.D. , Georgia Chenevix-Trench , for AOCS , /ACS Group , Rossing M.A. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014 Jul; 23(7), p. 1421-7.
EPub date: 2014-04-16.
PMID: 24740199
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Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.
Authors: Earp M.A. , Kelemen L.E. , Magliocco A.M. , Swenerton K.D. , Chenevix-Trench G. , Australian Cancer Study , Australian Ovarian Cancer Study Group , Lu Y. , Hein A. , Ekici A.B. , et al. .
Source: Human genetics, 2014 May; 133(5), p. 481-97.
EPub date: 2013-11-05.
PMID: 24190013
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Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome.
Authors: Charbonneau B. , Moysich K.B. , Kalli K.R. , Oberg A.L. , Vierkant R.A. , Fogarty Z.C. , Block M.S. , Maurer M.J. , Goergen K.M. , Fridley B.L. , et al. .
Source: Cancer immunology research, 2014 Apr; 2(4), p. 332-40.
EPub date: 2014-01-27.
PMID: 24764580
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Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10.
Authors: Charbonneau B. , Block M.S. , Bamlet W.R. , Vierkant R.A. , Kalli K.R. , Fogarty Z. , Rider D.N. , Sellers T.A. , Tworoger S.S. , Poole E. , et al. .
Source: Cancer research, 2014-02-01; 74(3), p. 852-61.
EPub date: 2013-11-22.
PMID: 24272484
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Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome.
Authors: White K.L. , Vierkant R.A. , Fogarty Z.C. , Charbonneau B. , Block M.S. , Pharoah P.D. , Chenevix-Trench G. , for AOCS/ACS group; , Rossing M.A. , Cramer D.W. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013 May; 22(5), p. 987-92.
EPub date: 2013-03-19.
PMID: 23513043
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Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.
Authors: Shen H. , Fridley B.L. , Song H. , Lawrenson K. , Cunningham J.M. , Ramus S.J. , Cicek M.S. , Tyrer J. , Stram D. , Larson M.C. , et al. .
Source: Nature communications, 2013; 4, p. 1628.
PMID: 23535649
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Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.
Authors: Permuth-Wey J. , Lawrenson K. , Shen H.C. , Velkova A. , Tyrer J.P. , Chen Z. , Lin H.Y. , Chen Y.A. , Tsai Y.Y. , Qu X. , et al. .
Source: Nature communications, 2013; 4, p. 1627.
PMID: 23535648
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Consumption of artificial sweetener- and sugar-containing soda and risk of lymphoma and leukemia in men and women.
Authors: Schernhammer E.S. , Bertrand K.A. , Birmann B.M. , Sampson L. , Willett W.C. , Feskanich D. .
Source: The American journal of clinical nutrition, 2012 Dec; 96(6), p. 1419-28.
EPub date: 2012-10-24.
PMID: 23097267
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Failed promises of the cigarette industry and its effect on consumer misperceptions about the health risks of smoking.
Authors: Cummings K.M. , Morley C.P. , Hyland A. .
Source: Tobacco control, 2002 Mar; 11 Suppl 1, p. I110-7.
PMID: 11893821
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The cigarette pack as image: new evidence from tobacco industry documents.
Authors: Wakefield M. , Morley C. , Horan J.K. , Cummings K.M. .
Source: Tobacco control, 2002 Mar; 11 Suppl 1, p. I73-80.
PMID: 11893817
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Tax, price and cigarette smoking: evidence from the tobacco documents and implications for tobacco company marketing strategies.
Authors: Chaloupka F.J. , Cummings K.M. , Morley C.P. , Horan J.K. .
Source: Tobacco control, 2002 Mar; 11 Suppl 1, p. I62-72.
PMID: 11893816
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Marketing to America's youth: evidence from corporate documents.
Authors: Cummings K.M. , Morley C.P. , Horan J.K. , Steger C. , Leavell N.R. .
Source: Tobacco control, 2002 Mar; 11 Suppl 1, p. I5-17.
PMID: 11893810
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