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Grant Details

Grant Number: 5R01CA085265-03 Interpret this number
Primary Investigator: Maskarinec, Gertraud
Organization: University Of Hawaii At Manoa
Project Title: Nested Case Control Study of Mammographic Density
Fiscal Year: 2002


Abstract

DESCRIPTION (Adapted from the Applicant's Abstract): The hypothesis for the proposed study is that women diagnosed with breast cancer have higher mammographic density patterns in prediagnostic mammograms than women without a diagnosis of breast cancer. In addition, we postulate that despite differences in mammographic density patterns among ethnic groups, the relation between mammographic densities and breast cancer risk is similar in Japanese, Native Hawaiian, and Caucasian women and that dietary factors contribute to the variation in mammographic densities among ethnic groups. A large multiethnic cohort in Hawaii established between 1993 and 1996 with well documented differences in breast cancer risk offers a unique opportunity to research these hypotheses. The specific aims of this project are to investigate the association between mammographic density patterns and breast cancer risk in women of Japanese, Native Hawaiian, and Caucasian ancestry, to examine the possible effect of dietary fat, fruit and vegetable intake, soy consumption, and other dietary components on mammographic densities, and to elucidate the relative importance of percent densities vs. the absolute size of the dense areas in relation to breast cancer risk in women of different ethnicity. We are proposing a nested case-control study using mammograms from women who are part of the multiethnic cohort. We will include 3 ethnic groups who represent the largest sub-groups: Caucasian, Japanese, and Native Hawaiian. Mammograms performed before the diagnosis of breast cancer will be obtained for women diagnosed with breast cancer between 1994 and 2000. For an equal number of healthy controls, matched by age and ethnicity, we will identify mammograms taken within 2 years of the time when the respective cases selected for Inclusion in the study received their mammogram. Women with the following characteristics will be excluded from the study: a diagnosis of breast cancer before entry into the cohort, bilateral breast cancer, no previous mammogram, and a previous history of breast augmentation, reduction surgery, or an extensive surgical biopsy with a diagnosis of benign breast disease. Based on breast cancer incidence in the cohort, mammography rates, and estimated participation rates, we plan to enroll approximately 1,000 cases and 1,000 controls with 500 Japanese, 300, Caucasian, and 200 Native Hawaiian per group. Potential study subjects will be contacted by mail and asked for permission to retrieve a suitable mammogram from their mammography clinic. Women will also complete a short questionnaire related to breast health. The statistical analysis will include logistic regression to estimate the risk of developing breast cancer in relation to mammographic density patterns and multiple linear regression to examine the association between diet and density patterns.



Publications

The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.
Authors: Ward S.V. , Burton A. , Tamimi R.M. , Pereira A. , Garmendia M.L. , Pollan M. , Boyd N. , Dos-Santos-Silva I. , Maskarinec G. , Perez-Gomez B. , et al. .
Source: Breast Cancer Research : Bcr, 2022-07-14 00:00:00.0; 24(1), p. 49.
EPub date: 2022-07-14 00:00:00.0.
PMID: 35836268
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Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort.
Authors: Maskarinec G. , Ju D. , Shvetsov Y.B. , Horio D. , Chan O. , Loo L.W.M. , Hernandez B.Y. .
Source: Cancer Epidemiology, 2020-02-11 00:00:00.0; 65, p. 101685.
EPub date: 2020-02-11 00:00:00.0.
PMID: 32058311
Related Citations

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk.
Authors: Vachon C.M. , Scott C.G. , Tamimi R.M. , Thompson D.J. , Fasching P.A. , Stone J. , Southey M.C. , Winham S. , Lindström S. , Lilyquist J. , et al. .
Source: Breast Cancer Research : Bcr, 2019-05-22 00:00:00.0; 21(1), p. 68.
EPub date: 2019-05-22 00:00:00.0.
PMID: 31118087
Related Citations

Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin.
Authors: Maskarinec G. , Ju D. , Fong J. , Horio D. , Chan O. , Loo L.W.M. , Hernandez B.Y. .
Source: Bmc Cancer, 2018-11-29 00:00:00.0; 18(1), p. 1191.
EPub date: 2018-11-29 00:00:00.0.
PMID: 30497427
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International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries.
Authors: McCormack V.A. , Burton A. , dos-Santos-Silva I. , Hipwell J.H. , Dickens C. , Salem D. , Kamal R. , Hartman M. , Lee C.P. , Chia K.S. , et al. .
Source: Cancer Epidemiology, 2016 Feb; 40, p. 141-51.
PMID: 26724463
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Novel Associations Between Common Breast Cancer Susceptibility Variants And Risk-predicting Mammographic Density Measures
Authors: Stone J. , Thompson D.J. , Dos Santos Silva I. , Scott C. , Tamimi R.M. , Lindstrom S. , Kraft P. , Hazra A. , Li J. , Eriksson L. , et al. .
Source: Cancer Research, 2015-06-15 00:00:00.0; 75(12), p. 2457-67.
PMID: 25862352
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Mammographic Density And Breast Cancer Risk By Family History In Women Of White And Asian Ancestry
Authors: Maskarinec G. , Nakamura K.L. , Woolcott C.G. , Conroy S.M. , Byrne C. , Nagata C. , Ursin G. , Vachon C.M. .
Source: Cancer Causes & Control : Ccc, 2015 Apr; 26(4), p. 621-6.
PMID: 25761408
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Mammographic Density Phenotypes And Risk Of Breast Cancer: A Meta-analysis
Authors: Pettersson A. , Graff R.E. , Ursin G. , Santos Silva I.D. , McCormack V. , Baglietto L. , Vachon C. , Bakker M.F. , Giles G.G. , Chia K.S. , et al. .
Source: Journal Of The National Cancer Institute, 2014 May; 106(5), .
PMID: 24816206
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Parity and expression of epithelial histopathologic markers in breast tissue.
Authors: Morimoto Y. , Killeen J. , Hernandez B.Y. , Mark Cline J. , Maskarinec G. .
Source: European Journal Of Cancer Prevention : The Official Journal Of The European Cancer Prevention Organisation (ecp), 2013 Sep; 22(5), p. 404-8.
PMID: 23222412
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Mammographic Density As A Predictor Of Breast Cancer Survival: The Multiethnic Cohort
Authors: Maskarinec G. , Pagano I.S. , Little M.A. , Conroy S.M. , Park S.Y. , Kolonel L.N. .
Source: Breast Cancer Research : Bcr, 2013; 15(1), p. R7.
PMID: 23339436
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Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.
Authors: Vachon C.M. , Scott C.G. , Fasching P.A. , Hall P. , Tamimi R.M. , Li J. , Stone J. , Apicella C. , Odefrey F. , Gierach G.L. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 Jul; 21(7), p. 1156-66.
PMID: 22454379
Related Citations

Mammographic Density And Hormone Receptor Expression In Breast Cancer: The Multiethnic Cohort Study
Authors: Conroy S.M. , Pagano I. , Kolonel L.N. , Maskarinec G. .
Source: Cancer Epidemiology, 2011 Oct; 35(5), p. 448-52.
PMID: 21247819
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Mammographic density and matrix metalloproteinases in breast tissue.
Authors: Steude J.S. , Maskarinec G. , Erber E. , Verheus M. , Hernandez B.Y. , Killeen J. , Cline J.M. .
Source: Cancer Microenvironment : Official Journal Of The International Cancer Microenvironment Society, 2010 Dec; 3(1), p. 57-65.
PMID: 20012240
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Igf1, Igfbp1, And Igfbp3 Genes And Mammographic Density: The Multiethnic Cohort
Authors: Verheus M. , Maskarinec G. , Woolcott C.G. , Haiman C.A. , Le Marchand L. , Henderson B.E. , Cheng I. , Kolonel L.N. .
Source: International Journal Of Cancer, 2010-09-01 00:00:00.0; 127(5), p. 1115-23.
PMID: 20039319
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Association Between Breast Cancer Susceptibility Loci And Mammographic Density: The Multiethnic Cohort
Authors: Woolcott C.G. , Maskarinec G. , Haiman C.A. , Verheus M. , Pagano I.S. , Le Marchand L. , Henderson B.E. , Kolonel L.N. .
Source: Breast Cancer Research : Bcr, 2009; 11(1), p. R10.
PMID: 19232126
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Mammographic Density And Epithelial Histopathologic Markers
Authors: Verheus M. , Maskarinec G. , Erber E. , Steude J.S. , Killeen J. , Hernandez B.Y. , Cline J.M. .
Source: Bmc Cancer, 2009; 9, p. 182.
PMID: 19523235
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Soy consumption and histopathologic markers in breast tissue using tissue microarrays.
Authors: Maskarinec G. , Erber E. , Verheus M. , Hernandez B.Y. , Killeen J. , Cashin S. , Cline J.M. .
Source: Nutrition And Cancer, 2009; 61(5), p. 708-16.
PMID: 19838945
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Nonsteroidal Anti-inflammatory Drugs (nsaids) And Mammographic Density
Authors: Maskarinec G. , Urano Y. , Gill J. , Kolonel L.N. .
Source: Breast Cancer Research And Treatment, 2008 Nov; 112(1), p. 133-9.
PMID: 18046643
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Soy Intake Is Related To A Lower Body Mass Index In Adult Women
Authors: Maskarinec G. , Aylward A.G. , Erber E. , Takata Y. , Kolonel L.N. .
Source: European Journal Of Nutrition, 2008 Apr; 47(3), p. 138-44.
PMID: 18427855
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Igf-i And Mammographic Density In Four Geographic Locations: A Pooled Analysis
Authors: Maskarinec G. , Takata Y. , Chen Z. , Gram I.T. , Nagata C. , Pagano I. , Hayashi K. , Arendell L. , Skeie G. , Rinaldi S. , et al. .
Source: International Journal Of Cancer, 2007-10-15 00:00:00.0; 121(8), p. 1786-92.
PMID: 17520679
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Mammographic Density And Dietary Patterns: The Multiethnic Cohort
Authors: Takata Y. , Maskarinec G. , Park S.Y. , Murphy S.P. , Wilkens L.R. , Kolonel L.N. .
Source: European Journal Of Cancer Prevention : The Official Journal Of The European Cancer Prevention Organisation (ecp), 2007 Oct; 16(5), p. 409-14.
PMID: 17923811
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Ethnic And Geographic Differences In Mammographic Density And Their Association With Breast Cancer Incidence
Authors: Maskarinec G. , Pagano I. , Chen Z. , Nagata C. , Gram I.T. .
Source: Breast Cancer Research And Treatment, 2007 Jul; 104(1), p. 47-56.
PMID: 17009106
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Breast Density And Polymorphisms In Genes Coding For Cyp1a2 And Comt: The Multiethnic Cohort
Authors: Takata Y. , Maskarinec G. , Le Marchand L. .
Source: Bmc Cancer, 2007-02-12 00:00:00.0; 7, p. 30.
PMID: 17295924
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Alcohol Consumption And Mammographic Density In A Multiethnic Population
Authors: Maskarinec G. , Takata Y. , Pagano I. , Lurie G. , Wilkens L.R. , Kolonel L.N. .
Source: International Journal Of Cancer, 2006-05-15 00:00:00.0; 118(10), p. 2579-83.
PMID: 16380998
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A Longitudinal Investigation Of Mammographic Density: The Multiethnic Cohort
Authors: Maskarinec G. , Pagano I. , Lurie G. , Kolonel L.N. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2006 Apr; 15(4), p. 732-9.
PMID: 16614116
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The Association Of Mammographic Density With Ductal Carcinoma In Situ Of The Breast: The Multiethnic Cohort
Authors: Gill J.K. , Maskarinec G. , Pagano I. , Kolonel L.N. .
Source: Breast Cancer Research : Bcr, 2006; 8(3), p. R30.
PMID: 16796758
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Serum Insulin-like Growth Factor-i Levels Among Women In Hawaii And Japan With Different Levels Of Tofu Intake
Authors: Takata Y. , Maskarinec G. , Rinaldi S. , Kaaks R. , Nagata C. .
Source: Nutrition And Cancer, 2006; 56(2), p. 136-42.
PMID: 17474858
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Mammographic Density And Breast Cancer Risk: The Multiethnic Cohort Study
Authors: Maskarinec G. , Pagano I. , Lurie G. , Wilkens L.R. , Kolonel L.N. .
Source: American Journal Of Epidemiology, 2005-10-15 00:00:00.0; 162(8), p. 743-52.
PMID: 16150892
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