Grant Number:	5R01CA085265-03 Interpret this number
Primary Investigator:	Maskarinec, Gertraud
Organization:	University Of Hawaii At Manoa
Project Title:	Nested Case Control Study of Mammographic Density
Fiscal Year:	2002

DESCRIPTION (Adapted from the Applicant's Abstract): The hypothesis for the proposed study is that women diagnosed with breast cancer have higher mammographic density patterns in prediagnostic mammograms than women without a diagnosis of breast cancer. In addition, we postulate that despite differences in mammographic density patterns among ethnic groups, the relation between mammographic densities and breast cancer risk is similar in Japanese, Native Hawaiian, and Caucasian women and that dietary factors contribute to the variation in mammographic densities among ethnic groups. A large multiethnic cohort in Hawaii established between 1993 and 1996 with well documented differences in breast cancer risk offers a unique opportunity to research these hypotheses. The specific aims of this project are to investigate the association between mammographic density patterns and breast cancer risk in women of Japanese, Native Hawaiian, and Caucasian ancestry, to examine the possible effect of dietary fat, fruit and vegetable intake, soy consumption, and other dietary components on mammographic densities, and to elucidate the relative importance of percent densities vs. the absolute size of the dense areas in relation to breast cancer risk in women of different ethnicity. We are proposing a nested case-control study using mammograms from women who are part of the multiethnic cohort. We will include 3 ethnic groups who represent the largest sub-groups: Caucasian, Japanese, and Native Hawaiian. Mammograms performed before the diagnosis of breast cancer will be obtained for women diagnosed with breast cancer between 1994 and 2000. For an equal number of healthy controls, matched by age and ethnicity, we will identify mammograms taken within 2 years of the time when the respective cases selected for Inclusion in the study received their mammogram. Women with the following characteristics will be excluded from the study: a diagnosis of breast cancer before entry into the cohort, bilateral breast cancer, no previous mammogram, and a previous history of breast augmentation, reduction surgery, or an extensive surgical biopsy with a diagnosis of benign breast disease. Based on breast cancer incidence in the cohort, mammography rates, and estimated participation rates, we plan to enroll approximately 1,000 cases and 1,000 controls with 500 Japanese, 300, Caucasian, and 200 Native Hawaiian per group. Potential study subjects will be contacted by mail and asked for permission to retrieve a suitable mammogram from their mammography clinic. Women will also complete a short questionnaire related to breast health. The statistical analysis will include logistic regression to estimate the risk of developing breast cancer in relation to mammographic density patterns and multiple linear regression to examine the association between diet and density patterns.




Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort.
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Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk.
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Source: Breast cancer research : BCR, 2019-05-22; 21(1), p. 68.
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PMID: 31118087
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Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin.
Authors: Maskarinec G. , Ju D. , Fong J. , Horio D. , Chan O. , Loo L.W.M. , Hernandez B.Y. .
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PMID: 30497427
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International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries.
Authors: McCormack V.A. , Burton A. , dos-Santos-Silva I. , Hipwell J.H. , Dickens C. , Salem D. , Kamal R. , Hartman M. , Lee C.P. , Chia K.S. , et al. .
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Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.
Authors: Stone J. , Thompson D.J. , Dos Santos Silva I. , Scott C. , Tamimi R.M. , Lindstrom S. , Kraft P. , Hazra A. , Li J. , Eriksson L. , et al. .
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Mammographic density and breast cancer risk by family history in women of white and Asian ancestry.
Authors: Maskarinec G. , Nakamura K.L. , Woolcott C.G. , Conroy S.M. , Byrne C. , Nagata C. , Ursin G. , Vachon C.M. .
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Mammographic density phenotypes and risk of breast cancer: a meta-analysis.
Authors: Pettersson A. , Graff R.E. , Ursin G. , Santos Silva I.D. , McCormack V. , Baglietto L. , Vachon C. , Bakker M.F. , Giles G.G. , Chia K.S. , et al. .
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Parity and expression of epithelial histopathologic markers in breast tissue.
Authors: Morimoto Y. , Killeen J. , Hernandez B.Y. , Mark Cline J. , Maskarinec G. .
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2013 Sep; 22(5), p. 404-8.
PMID: 23222412
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Mammographic density as a predictor of breast cancer survival: the Multiethnic Cohort.
Authors: Maskarinec G. , Pagano I.S. , Little M.A. , Conroy S.M. , Park S.Y. , Kolonel L.N. .
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Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.
Authors: Vachon C.M. , Scott C.G. , Fasching P.A. , Hall P. , Tamimi R.M. , Li J. , Stone J. , Apicella C. , Odefrey F. , Gierach G.L. , et al. .
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PMID: 22454379
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Mammographic density and hormone receptor expression in breast cancer: the Multiethnic Cohort Study.
Authors: Conroy S.M. , Pagano I. , Kolonel L.N. , Maskarinec G. .
Source: Cancer epidemiology, 2011 Oct; 35(5), p. 448-52.
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PMID: 21247819
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Mammographic density and matrix metalloproteinases in breast tissue.
Authors: Steude J.S. , Maskarinec G. , Erber E. , Verheus M. , Hernandez B.Y. , Killeen J. , Cline J.M. .
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IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort.
Authors: Verheus M. , Maskarinec G. , Woolcott C.G. , Haiman C.A. , Le Marchand L. , Henderson B.E. , Cheng I. , Kolonel L.N. .
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Mammographic density and epithelial histopathologic markers.
Authors: Verheus M. , Maskarinec G. , Erber E. , Steude J.S. , Killeen J. , Hernandez B.Y. , Cline J.M. .
Source: BMC cancer, 2009-06-13; 9, p. 182.
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Soy consumption and histopathologic markers in breast tissue using tissue microarrays.
Authors: Maskarinec G. , Erber E. , Verheus M. , Hernandez B.Y. , Killeen J. , Cashin S. , Cline J.M. .
Source: Nutrition and cancer, 2009; 61(5), p. 708-16.
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Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.
Authors: Woolcott C.G. , Maskarinec G. , Haiman C.A. , Verheus M. , Pagano I.S. , Le Marchand L. , Henderson B.E. , Kolonel L.N. .
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Nonsteroidal anti-inflammatory drugs (NSAIDs) and mammographic density.
Authors: Maskarinec G. , Urano Y. , Gill J. , Kolonel L.N. .
Source: Breast cancer research and treatment, 2008 Nov; 112(1), p. 133-9.
EPub date: 2007-11-29.
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Soy intake is related to a lower body mass index in adult women.
Authors: Maskarinec G. , Aylward A.G. , Erber E. , Takata Y. , Kolonel L.N. .
Source: European journal of nutrition, 2008 Apr; 47(3), p. 138-44.
EPub date: 2008-04-22.
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IGF-I and mammographic density in four geographic locations: a pooled analysis.
Authors: Maskarinec G. , Takata Y. , Chen Z. , Gram I.T. , Nagata C. , Pagano I. , Hayashi K. , Arendell L. , Skeie G. , Rinaldi S. , et al. .
Source: International journal of cancer, 2007-10-15; 121(8), p. 1786-92.
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Mammographic density and dietary patterns: the multiethnic cohort.
Authors: Takata Y. , Maskarinec G. , Park S.Y. , Murphy S.P. , Wilkens L.R. , Kolonel L.N. .
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2007 Oct; 16(5), p. 409-14.
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Ethnic and geographic differences in mammographic density and their association with breast cancer incidence.
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Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort.
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Alcohol consumption and mammographic density in a multiethnic population.
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Serum insulin-like growth factor-I levels among women in Hawaii and Japan with different levels of tofu intake.
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The association of mammographic density with ductal carcinoma in situ of the breast: the Multiethnic Cohort.
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