Grant Details
Grant Number: |
5R01CA085265-03 Interpret this number |
Primary Investigator: |
Maskarinec, Gertraud |
Organization: |
University Of Hawaii At Manoa |
Project Title: |
Nested Case Control Study of Mammographic Density |
Fiscal Year: |
2002 |
Abstract
DESCRIPTION (Adapted from the Applicant's Abstract): The hypothesis for the
proposed study is that women diagnosed with breast cancer have higher
mammographic density patterns in prediagnostic mammograms than women without a
diagnosis of breast cancer. In addition, we postulate that despite differences
in mammographic density patterns among ethnic groups, the relation between
mammographic densities and breast cancer risk is similar in Japanese, Native
Hawaiian, and Caucasian women and that dietary factors contribute to the
variation in mammographic densities among ethnic groups. A large multiethnic
cohort in Hawaii established between 1993 and 1996 with well documented
differences in breast cancer risk offers a unique opportunity to research these
hypotheses. The specific aims of this project are to investigate the
association between mammographic density patterns and breast cancer risk in
women of Japanese, Native Hawaiian, and Caucasian ancestry, to examine the
possible effect of dietary fat, fruit and vegetable intake, soy consumption,
and other dietary components on mammographic densities, and to elucidate the
relative importance of percent densities vs. the absolute size of the dense
areas in relation to breast cancer risk in women of different ethnicity.
We are proposing a nested case-control study using mammograms from women who
are part of the multiethnic cohort. We will include 3 ethnic groups who
represent the largest sub-groups: Caucasian, Japanese, and Native Hawaiian.
Mammograms performed before the diagnosis of breast cancer will be obtained for
women diagnosed with breast cancer between 1994 and 2000. For an equal number
of healthy controls, matched by age and ethnicity, we will identify mammograms
taken within 2 years of the time when the respective cases selected for
Inclusion in the study received their mammogram. Women with the following
characteristics will be excluded from the study: a diagnosis of breast cancer
before entry into the cohort, bilateral breast cancer, no previous mammogram,
and a previous history of breast augmentation, reduction surgery, or an
extensive surgical biopsy with a diagnosis of benign breast disease. Based on
breast cancer incidence in the cohort, mammography rates, and estimated
participation rates, we plan to enroll approximately 1,000 cases and 1,000
controls with 500 Japanese, 300, Caucasian, and 200 Native Hawaiian per group.
Potential study subjects will be contacted by mail and asked for permission to
retrieve a suitable mammogram from their mammography clinic. Women will also
complete a short questionnaire related to breast health. The statistical
analysis will include logistic regression to estimate the risk of developing
breast cancer in relation to mammographic density patterns and multiple linear
regression to examine the association between diet and density patterns.
Publications
Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort.
Authors: Maskarinec G.
, Ju D.
, Shvetsov Y.B.
, Horio D.
, Chan O.
, Loo L.W.M.
, Hernandez B.Y.
.
Source: Cancer epidemiology, 2020 04; 65, p. 101685.
EPub date: 2020-02-12.
PMID: 32058311
Related Citations
Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk.
Authors: Vachon C.M.
, Scott C.G.
, Tamimi R.M.
, Thompson D.J.
, Fasching P.A.
, Stone J.
, Southey M.C.
, Winham S.
, Lindström S.
, Lilyquist J.
, et al.
.
Source: Breast cancer research : BCR, 2019-05-22; 21(1), p. 68.
EPub date: 2019-05-22.
PMID: 31118087
Related Citations
Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin.
Authors: Maskarinec G.
, Ju D.
, Fong J.
, Horio D.
, Chan O.
, Loo L.W.M.
, Hernandez B.Y.
.
Source: BMC cancer, 2018-11-29; 18(1), p. 1191.
EPub date: 2018-11-29.
PMID: 30497427
Related Citations
International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries.
Authors: McCormack V.A.
, Burton A.
, dos-Santos-Silva I.
, Hipwell J.H.
, Dickens C.
, Salem D.
, Kamal R.
, Hartman M.
, Lee C.P.
, Chia K.S.
, et al.
.
Source: Cancer epidemiology, 2016 Feb; 40, p. 141-51.
EPub date: 2015-12-24.
PMID: 26724463
Related Citations
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures.
Authors: Stone J.
, Thompson D.J.
, Dos Santos Silva I.
, Scott C.
, Tamimi R.M.
, Lindstrom S.
, Kraft P.
, Hazra A.
, Li J.
, Eriksson L.
, et al.
.
Source: Cancer research, 2015-06-15; 75(12), p. 2457-67.
EPub date: 2015-04-10.
PMID: 25862352
Related Citations
Mammographic density and breast cancer risk by family history in women of white and Asian ancestry.
Authors: Maskarinec G.
, Nakamura K.L.
, Woolcott C.G.
, Conroy S.M.
, Byrne C.
, Nagata C.
, Ursin G.
, Vachon C.M.
.
Source: Cancer causes & control : CCC, 2015 Apr; 26(4), p. 621-6.
EPub date: 2015-03-12.
PMID: 25761408
Related Citations
Mammographic density phenotypes and risk of breast cancer: a meta-analysis.
Authors: Pettersson A.
, Graff R.E.
, Ursin G.
, Santos Silva I.D.
, McCormack V.
, Baglietto L.
, Vachon C.
, Bakker M.F.
, Giles G.G.
, Chia K.S.
, et al.
.
Source: Journal of the National Cancer Institute, 2014-05-10; 106(5), .
EPub date: 2014-05-10.
PMID: 24816206
Related Citations
Parity and expression of epithelial histopathologic markers in breast tissue.
Authors: Morimoto Y.
, Killeen J.
, Hernandez B.Y.
, Mark Cline J.
, Maskarinec G.
.
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2013 Sep; 22(5), p. 404-8.
PMID: 23222412
Related Citations
Mammographic density as a predictor of breast cancer survival: the Multiethnic Cohort.
Authors: Maskarinec G.
, Pagano I.S.
, Little M.A.
, Conroy S.M.
, Park S.Y.
, Kolonel L.N.
.
Source: Breast cancer research : BCR, 2013-01-22; 15(1), p. R7.
EPub date: 2013-01-22.
PMID: 23339436
Related Citations
Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.
Authors: Vachon C.M.
, Scott C.G.
, Fasching P.A.
, Hall P.
, Tamimi R.M.
, Li J.
, Stone J.
, Apicella C.
, Odefrey F.
, Gierach G.L.
, et al.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012 Jul; 21(7), p. 1156-66.
EPub date: 2012-03-27.
PMID: 22454379
Related Citations
Mammographic density and hormone receptor expression in breast cancer: the Multiethnic Cohort Study.
Authors: Conroy S.M.
, Pagano I.
, Kolonel L.N.
, Maskarinec G.
.
Source: Cancer epidemiology, 2011 Oct; 35(5), p. 448-52.
EPub date: 2011-01-17.
PMID: 21247819
Related Citations
Mammographic density and matrix metalloproteinases in breast tissue.
Authors: Steude J.S.
, Maskarinec G.
, Erber E.
, Verheus M.
, Hernandez B.Y.
, Killeen J.
, Cline J.M.
.
Source: Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 2010 Dec; 3(1), p. 57-65.
EPub date: 2009-12-10.
PMID: 20012240
Related Citations
IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort.
Authors: Verheus M.
, Maskarinec G.
, Woolcott C.G.
, Haiman C.A.
, Le Marchand L.
, Henderson B.E.
, Cheng I.
, Kolonel L.N.
.
Source: International journal of cancer, 2010-09-01; 127(5), p. 1115-23.
PMID: 20039319
Related Citations
Mammographic density and epithelial histopathologic markers.
Authors: Verheus M.
, Maskarinec G.
, Erber E.
, Steude J.S.
, Killeen J.
, Hernandez B.Y.
, Cline J.M.
.
Source: BMC cancer, 2009-06-13; 9, p. 182.
EPub date: 2009-06-13.
PMID: 19523235
Related Citations
Soy consumption and histopathologic markers in breast tissue using tissue microarrays.
Authors: Maskarinec G.
, Erber E.
, Verheus M.
, Hernandez B.Y.
, Killeen J.
, Cashin S.
, Cline J.M.
.
Source: Nutrition and cancer, 2009; 61(5), p. 708-16.
PMID: 19838945
Related Citations
Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.
Authors: Woolcott C.G.
, Maskarinec G.
, Haiman C.A.
, Verheus M.
, Pagano I.S.
, Le Marchand L.
, Henderson B.E.
, Kolonel L.N.
.
Source: Breast cancer research : BCR, 2009; 11(1), p. R10.
EPub date: 2009-02-21.
PMID: 19232126
Related Citations
Nonsteroidal anti-inflammatory drugs (NSAIDs) and mammographic density.
Authors: Maskarinec G.
, Urano Y.
, Gill J.
, Kolonel L.N.
.
Source: Breast cancer research and treatment, 2008 Nov; 112(1), p. 133-9.
EPub date: 2007-11-29.
PMID: 18046643
Related Citations
Soy intake is related to a lower body mass index in adult women.
Authors: Maskarinec G.
, Aylward A.G.
, Erber E.
, Takata Y.
, Kolonel L.N.
.
Source: European journal of nutrition, 2008 Apr; 47(3), p. 138-44.
EPub date: 2008-04-22.
PMID: 18427855
Related Citations
IGF-I and mammographic density in four geographic locations: a pooled analysis.
Authors: Maskarinec G.
, Takata Y.
, Chen Z.
, Gram I.T.
, Nagata C.
, Pagano I.
, Hayashi K.
, Arendell L.
, Skeie G.
, Rinaldi S.
, et al.
.
Source: International journal of cancer, 2007-10-15; 121(8), p. 1786-92.
PMID: 17520679
Related Citations
Mammographic density and dietary patterns: the multiethnic cohort.
Authors: Takata Y.
, Maskarinec G.
, Park S.Y.
, Murphy S.P.
, Wilkens L.R.
, Kolonel L.N.
.
Source: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2007 Oct; 16(5), p. 409-14.
PMID: 17923811
Related Citations
Ethnic and geographic differences in mammographic density and their association with breast cancer incidence.
Authors: Maskarinec G.
, Pagano I.
, Chen Z.
, Nagata C.
, Gram I.T.
.
Source: Breast cancer research and treatment, 2007 Jul; 104(1), p. 47-56.
EPub date: 2006-09-29.
PMID: 17009106
Related Citations
Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort.
Authors: Takata Y.
, Maskarinec G.
, Le Marchand L.
.
Source: BMC cancer, 2007-02-12; 7, p. 30.
EPub date: 2007-02-12.
PMID: 17295924
Related Citations
Alcohol consumption and mammographic density in a multiethnic population.
Authors: Maskarinec G.
, Takata Y.
, Pagano I.
, Lurie G.
, Wilkens L.R.
, Kolonel L.N.
.
Source: International journal of cancer, 2006-05-15; 118(10), p. 2579-83.
PMID: 16380998
Related Citations
A longitudinal investigation of mammographic density: the multiethnic cohort.
Authors: Maskarinec G.
, Pagano I.
, Lurie G.
, Kolonel L.N.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006 Apr; 15(4), p. 732-9.
PMID: 16614116
Related Citations
Serum insulin-like growth factor-I levels among women in Hawaii and Japan with different levels of tofu intake.
Authors: Takata Y.
, Maskarinec G.
, Rinaldi S.
, Kaaks R.
, Nagata C.
.
Source: Nutrition and cancer, 2006; 56(2), p. 136-42.
PMID: 17474858
Related Citations
The association of mammographic density with ductal carcinoma in situ of the breast: the Multiethnic Cohort.
Authors: Gill J.K.
, Maskarinec G.
, Pagano I.
, Kolonel L.N.
.
Source: Breast cancer research : BCR, 2006; 8(3), p. R30.
EPub date: 2006-06-23.
PMID: 16796758
Related Citations
Mammographic density and breast cancer risk: the multiethnic cohort study.
Authors: Maskarinec G.
, Pagano I.
, Lurie G.
, Wilkens L.R.
, Kolonel L.N.
.
Source: American journal of epidemiology, 2005-10-15; 162(8), p. 743-52.
EPub date: 2005-09-08.
PMID: 16150892
Related Citations