The localization and characterization of tumor suppressor genes has
profound implications for prevention and treatment of cancer. The
primary goal of this research is to develop statistical tools to
expedite the search for tumor suppressor gene candidates. The specific
aims of this research are: to develop statistical significance tests
that will help identify tumor suppressor gene candidates from loss of
heterozygosity studies and deletion mapping studies; to provide methods
for determining whether allelic loss patterns from different groups of
patients are significantly different; to produce publicly available
software for implementing these procedures; and to estimate biologically
important characteristics of the allelic loss process in neoplastic
progression.
The methods for achieving these aims will involve the formulation of
models for genetic events in tumorigenesis, focusing primarily on
allelic loss events. Power studies will be performed which will allow
scientists to determine the sample sizes to achieve various levels of
certainty in the identification of tumor suppressor gene candidates.
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