Grant Number:	5U01CA078296-05 Interpret this number
Primary Investigator:	Anton-Culver, Hoda
Organization:	University Of California Irvine
Project Title:	NCI Cfrbccs Informatics Center at Uci
Fiscal Year:	2002

DESCRIPTION: Advanced technology for mutation detection, the cloning of several cancer susceptibility genes, and high-throughput sequencing of genes make obsolete many of the previous and some of the current research strategies in the genetic epidemiology of cancer. In addition, the clinical implications of inherited mutations will need to be defined and communicated to health care providers and cancer genetics professionals. To provide an infrastructure for studies in human cancer genetics of unprecedented size and complexity, the National Cancer Institute has initiated the Cooperative Family Registry for Breast and Colon Cancer Studies (CFRBCCS). Integral to this effort will be a state-of-the-art Informatics Center (IC), that will develop, implement, and maintain a central informatics system and provide technical expertise for the development of information technologies, statistical methodology, and study design. Collectively, the University of California at Irvine (UCI), Dartmouth Medical School, and the University of Southern California have extensive experience in developing information management systems, participating in and coordinating multi-center research efforts, and developing advanced techniques in biostatistics. Further, leading international experts in biostatistics, genetic epidemiology, and molecular genetics will participate as members in the Biostatistics, Genetics, and Epidemiology Consortium, to provide technical expertise to CFRBCCS researchers. Our specific aims are: 1) Develop, implement, and maintain a single central informatics system at UCI, 2) Provide summary data, support, and coordination for the CFRBCCS registries, 3) Provide technical expertise regarding statistical issues, study design, methodology, and information technologies for the Registries, through an international consortium of leading experts in biostatistics, genetic epidemiology, and molecular genetics, 4) Carry out the responsibility for the CFRBCCS Study-wide communication, coordination, and administrative duties.




Survival of Middle Eastern and North African Individuals Diagnosed with Colorectal Cancer: A Population-Based Study in California.
Authors: Zaki T.A. , Ziogas A. , Chang J. , Murphy C.C. , Anton-Culver H. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-06-01 00:00:00.0; 32(6), p. 795-801.
PMID: 37012208
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Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry.
Authors: Resler A.J. , Makar K.W. , Heath L. , Whitton J. , Potter J.D. , Poole E.M. , Habermann N. , Scherer D. , Duggan D. , Wang H. , et al. .
Source: Carcinogenesis, 2014 Sep; 35(9), p. 2121-6.
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Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: colon cancer family registry.
Authors: Scherer D. , Koepl L.M. , Poole E.M. , Balavarca Y. , Xiao L. , Baron J.A. , Hsu L. , Coghill A.E. , Campbell P.T. , Kleinstein S.E. , et al. .
Source: Genes, Chromosomes & Cancer, 2014 Jul; 53(7), p. 568-78.
PMID: 24677636
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How Do Researchers Manage Genetic Results In Practice? The Experience Of The Multinational Colon Cancer Family Registry
Authors: Keogh L.A. , Fisher D. , Sheinfeld Gorin S. , Schully S.D. , Lowery J.T. , Ahnen D.J. , Maskiell J.A. , Lindor N.M. , Hopper J.L. , Burnett T. , et al. .
Source: Journal Of Community Genetics, 2014 Apr; 5(2), p. 99-108.
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COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations.
Authors: Makar K.W. , Poole E.M. , Resler A.J. , Seufert B. , Curtin K. , Kleinstein S.E. , Duggan D. , Kulmacz R.J. , Hsu L. , Whitton J. , et al. .
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PMID: 24022467
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Identification Of Novel Variants In Colorectal Cancer Families By High-throughput Exome Sequencing
Authors: DeRycke M.S. , Gunawardena S.R. , Middha S. , Asmann Y.W. , Schaid D.J. , McDonnell S.K. , Riska S.M. , Eckloff B.W. , Cunningham J.M. , Fridley B.L. , et al. .
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Survival After Inflammatory Bowel Disease-associated Colorectal Cancer In The Colon Cancer Family Registry
Authors: Adams S.V. , Ahnen D.J. , Baron J.A. , Campbell P.T. , Gallinger S. , Grady W.M. , LeMarchand L. , Lindor N.M. , Potter J.D. , Newcomb P.A. .
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Identification Of Constitutional Mlh1 Epimutations And Promoter Variants In Colorectal Cancer Patients From The Colon Cancer Family Registry
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A Multifactorial Likelihood Model For Mmr Gene Variant Classification Incorporating Probabilities Based On Sequence Bioinformatics And Tumor Characteristics: A Report From The Colon Cancer Family Registry
Authors: Thompson B.A. , Goldgar D.E. , Paterson C. , Clendenning M. , Walters R. , Arnold S. , Parsons M.T. , Michael D W. , Gallinger S. , Haile R.W. , et al. .
Source: Human Mutation, 2013 Jan; 34(1), p. 200-9.
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I¿bkß And Nf¿b1, Nsaid Use And Risk Of Colorectal Cancer In The Colon Cancer Family Registry
Authors: Seufert B.L. , Poole E.M. , Whitton J. , Xiao L. , Makar K.W. , Campbell P.T. , Kulmacz R.J. , Baron J.A. , Newcomb P.A. , Slattery M.L. , et al. .
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Genetic Variations In Smad7 Are Associated With Colorectal Cancer Risk In The Colon Cancer Family Registry
Authors: Jiang X. , Castelao J.E. , Vandenberg D. , Carracedo A. , Redondo C.M. , Conti D.V. , Paredes Cotoré J.P. , Potter J.D. , Newcomb P.A. , Passarelli M.N. , et al. .
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Admixture Mapping Identifies A Locus On 6q25 Associated With Breast Cancer Risk In Us Latinas
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Colorectal Cancer Linkage On Chromosomes 4q21, 8q13, 12q24, And 15q22
Authors: Cicek M.S. , Cunningham J.M. , Fridley B.L. , Serie D.J. , Bamlet W.R. , Diergaarde B. , Haile R.W. , Le Marchand L. , Krontiris T.G. , Younghusband H.B. , et al. .
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Quality Assessment And Correlation Of Microsatellite Instability And Immunohistochemical Markers Among Population- And Clinic-based Colorectal Tumors Results From The Colon Cancer Family Registry
Authors: Cicek M.S. , Lindor N.M. , Gallinger S. , Bapat B. , Hopper J.L. , Jenkins M.A. , Young J. , Buchanan D. , Walsh M.D. , Le Marchand L. , et al. .
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Germline Pkhd1 Mutations Are Protective Against Colorectal Cancer
Authors: Ward C.J. , Wu Y. , Johnson R.A. , Woollard J.R. , Bergstralh E.J. , Cicek M.S. , Bakeberg J. , Rossetti S. , Heyer C.M. , Petersen G.M. , et al. .
Source: Human Genetics, 2011 Mar; 129(3), p. 345-9.
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Frequency Of Deletions Of Epcam (tacstd1) In Msh2-associated Lynch Syndrome Cases
Authors: Rumilla K. , Schowalter K.V. , Lindor N.M. , Thomas B.C. , Mensink K.A. , Gallinger S. , Holter S. , Newcomb P.A. , Potter J.D. , Jenkins M.A. , et al. .
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Use of folic acid-containing supplements after a diagnosis of colorectal cancer in the Colon Cancer Family Registry.
Authors: Holmes R.S. , Zheng Y. , Baron J.A. , Li L. , McKeown-Eyssen G. , Newcomb P.A. , Stern M.C. , Haile R.W. , Grady W.M. , Potter J.D. , et al. .
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Parent Of Origin Effects On Age At Colorectal Cancer Diagnosis
Authors: Lindor N.M. , Rabe K.G. , Petersen G.M. , Chen H. , Bapat B. , Hopper J. , Young J. , Jenkins M. , Potter J. , Newcomb P. , et al. .
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Confirmation Of Linkage To And Localization Of Familial Colon Cancer Risk Haplotype On Chromosome 9q22
Authors: Gray-McGuire C. , Guda K. , Adrianto I. , Lin C.P. , Natale L. , Potter J.D. , Newcomb P. , Poole E.M. , Ulrich C.M. , Lindor N. , et al. .
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The Association Of Tumor Microsatellite Instability Phenotype With Family History Of Colorectal Cancer
Authors: Bapat B. , Lindor N.M. , Baron J. , Siegmund K. , Li L. , Zheng Y. , Haile R. , Gallinger S. , Jass J.R. , Young J.P. , et al. .
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Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
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Colon Cancer Family Registry: An International Resource For Studies Of The Genetic Epidemiology Of Colon Cancer
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Ascending The Learning Curve--msi Testing Experience Of A Six-laboratory Consortium
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Isolated Loss Of Pms2 Expression In Colorectal Cancers: Frequency, Patient Age, And Familial Aggregation
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Familial Mutations In Pms2 Can Cause Autosomal Dominant Hereditary Nonpolyposis Colorectal Cancer
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Lower Cancer Incidence In Amsterdam-i Criteria Families Without Mismatch Repair Deficiency: Familial Colorectal Cancer Type X
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Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer.
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Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations.
Authors: Andrulis I.L. , Anton-Culver H. , Beck J. , Bove B. , Boyd J. , Buys S. , Godwin A.K. , Hopper J.L. , Li F. , Neuhausen S.L. , et al. .
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Ascertainment Bias In Family-based Case-control Studies
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