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Grant Details

Grant Number: 5U01CA078284-05 Interpret this number
Primary Investigator: Finkelstein, Dianne
Organization: Massachusetts General Hospital
Project Title: Coordinating Center for the Cancer Genetics Network
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Applicant's Description) We propose to be part of the Informatics and Information Technology Group which provides informatics support for the NCI's Cancer Genetics Network, a multicenter interdisciplinary cooperative that will provide the infrastructure for research investigations of the genetic basis of human cancer susceptibility, explore mechanisms for integrating this information into medical practice, and identify means to address the public health issues associated with human cancer genetics. The Informatics Network will consist of three aspects: 1. Information support for a Registry of individuals of who are interested in participating in investigations. 2. An Electronic Access to Genetic Services, educational materials, and research protocols and 3. A Coordinating Center for Network Research Protocols. Our proposal is to fulfill the third task, to provide the coordination and implementation of network research protocols. We will provide expert biostatistical support to help design studies. We will coordinate protocol development, forms development, randomization and the collection and storage of patient specimens. We assume the Informatics Support Group for the Registry will provide a distributed data acquisition system. Personnel at each site will be responsible for maintaining their data using the system, and we will be responsible for maintaining their data using the system, and we will have a database which is a replicate of those at the sites. We will review the incoming data for completeness and accuracy and generate reports that monitor accrual and data quality. In addition we will periodically visit each site to audit a random sample of the transmitted data and review how well the site is following study procedures. We will generate interim statistical reports and generate a final repot when studies are completed. We will develop new statistical and data management methods, where necessary, to meet the goals of the network. In addition we will organize network steering committee meetings and establish a communications system for the network based on electronic mail, the World Wide Web, telephone conference calls, and periodic mailings. We will coordinate our activities with the other members of the Informatics Technology group.

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Publications

Are rare cancer survivors at elevated risk of subsequent new cancers?
Authors: Finkelstein D.M. , Horick N.K. , Ramchandani R. , Boyd K.L. , Rana H.Q. , Bychkovsky B.L. .
Source: BMC cancer, 2019-02-21; 19(1), p. 166.
EPub date: 2019-02-21.
PMID: 30791872
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Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials.
Authors: Skates S.J. , Greene M.H. , Buys S.S. , Mai P.L. , Brown P. , Piedmonte M. , Rodriguez G. , Schorge J.O. , Sherman M. , Daly M.B. , et al. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2017-07-15; 23(14), p. 3628-3637.
EPub date: 2017-01-31.
PMID: 28143870
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Long-term risk of medical conditions associated with breast cancer treatment.
Authors: Hill D.A. , Horick N.K. , Isaacs C. , Domchek S.M. , Tomlinson G.E. , Lowery J.T. , Kinney A.Y. , Berg J.S. , Edwards K.L. , Moorman P.G. , et al. .
Source: Breast cancer research and treatment, 2014 May; 145(1), p. 233-43.
EPub date: 2014-04-03.
PMID: 24696430
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A randomized trial to increase colonoscopy screening in members of high-risk families in the colorectal cancer family registry and cancer genetics network.
Authors: Lowery J.T. , Horick N. , Kinney A.Y. , Finkelstein D.M. , Garrett K. , Haile R.W. , Lindor N.M. , Newcomb P.A. , Sandler R.S. , Burke C. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014 Apr; 23(4), p. 601-10.
EPub date: 2014-02-05.
PMID: 24501379
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Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status.
Authors: Skates S.J. , Mai P. , Horick N.K. , Piedmonte M. , Drescher C.W. , Isaacs C. , Armstrong D.K. , Buys S.S. , Rodriguez G.C. , Horowitz I.R. , et al. .
Source: Cancer prevention research (Philadelphia, Pa.), 2011 Sep; 4(9), p. 1401-8.
PMID: 21893500
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Clinically relevant changes in family history of cancer over time.
Authors: Ziogas A. , Horick N.K. , Kinney A.Y. , Lowery J.T. , Domchek S.M. , Isaacs C. , Griffin C.A. , Moorman P.G. , Edwards K.L. , Hill D.A. , et al. .
Source: JAMA, 2011-07-13; 306(2), p. 172-8.
PMID: 21750294
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Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.
Authors: Moorman P.G. , Iversen E.S. , Marcom P.K. , Marks J.R. , Wang F. , Kathleen Cuningham Consortium for Research into Familial Breast Cancer , Lee E. , Ursin G. , Rebbeck T.R. , Domchek S.M. , et al. .
Source: Breast cancer research and treatment, 2010 Nov; 124(2), p. 441-51.
EPub date: 2010-03-23.
PMID: 20309627
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Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis.
Authors: Neklason D.W. , Kerber R.A. , Nilson D.B. , Anton-Culver H. , Schwartz A.G. , Griffin C.A. , Lowery J.T. , Schildkraut J.M. , Evans J.P. , Tomlinson G.E. , et al. .
Source: Cancer research, 2008-11-01; 68(21), p. 8993-7.
PMID: 18974144
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Analysis of familial aggregation studies with complex ascertainment schemes.
Authors: Matthews A.G. , Finkelstein D.M. , Betensky R.A. .
Source: Statistics in medicine, 2008-10-30; 27(24), p. 5076-92.
PMID: 18618413
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Urokinase-type plasminogen activator receptor: a beacon of malignancy?
Authors: Drapkin R. , Clauss A. , Skates S. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2008-09-15; 14(18), p. 5643-5.
PMID: 18794069
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Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
Authors: Kerber R.A. , Amos C.I. , Yeap B.Y. , Finkelstein D.M. , Thomas D.C. .
Source: BMC medical genetics, 2008-07-10; 9, p. 64.
EPub date: 2008-07-10.
PMID: 18616822
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Validity of models for predicting BRCA1 and BRCA2 mutations.
Authors: Parmigiani G. , Chen S. , Iversen E.S. , Friebel T.M. , Finkelstein D.M. , Anton-Culver H. , Ziogas A. , Weber B.L. , Eisen A. , Malone K.E. , et al. .
Source: Annals of internal medicine, 2007-10-02; 147(7), p. 441-50.
PMID: 17909205
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Multivariate logistic regression for familial aggregation in age at disease onset.
Authors: Matthews A.G. , Finkelstein D.M. , Betensky R.A. .
Source: Lifetime data analysis, 2007 Jun; 13(2), p. 191-209.
EPub date: 2007-04-05.
PMID: 17410428
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Characterization of BRCA1 and BRCA2 mutations in a large United States sample.
Authors: Chen S. , Iversen E.S. , Friebel T. , Finkelstein D. , Weber B.L. , Eisen A. , Peterson L.E. , Schildkraut J.M. , Isaacs C. , Peshkin B.N. , et al. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-02-20; 24(6), p. 863-71.
PMID: 16484695
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Comparing survival of a sample to that of a standard population.
Authors: Finkelstein D.M. , Muzikansky A. , Schoenfeld D.A. .
Source: Journal of the National Cancer Institute, 2003-10-01; 95(19), p. 1434-9.
PMID: 14519749
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Screening for ovarian cancer-risk, education, worry: path to appropriate use?
Authors: Skates S.J. .
Source: Gynecologic oncology, 2002 Apr; 85(1), p. 1-2.
PMID: 11925112
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