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Grant Details

Grant Number: 5U24CA078142-05 Interpret this number
Primary Investigator: Strong, Louise
Organization: University Of Texas Md Anderson Can Ctr
Project Title: Texas Cancer Genetics Consortium
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Applicant's Description) We propose a Texas Cancer Genetics Consortium (TCGC) in response to the Cancer Genetics Network (CGN) RFA CA-97-004. This TCGC would bring to the CGN extensive expertise in basic and clinical cancer genetics, human and molecular genetics, management of confidential human cancer genetics data, community outreach in human genetics, professional and public education, and psychosocial studies of the impact of cancer genetic counseling and testing. The TCGC will include existing cancer high risk clinical populations, Ashkenazi Jewish populations, registries of familial breast, colon, MEN2, NF1 and other genetic susceptibility syndromes, many followed in studies for decades, patients at high cancer risk participating in screening and early detection studies or chemoprevention trials, and a large database of cancer patients from which to identify high risk family members for potential recruitment to the CGN. The Texas population is diverse in ethnic makeup, and the TCGC includes investigators with proven track records in assessing needs of the Hispanic and African American communities in health care, in providing health education to those communities and their healthcare providers, and in recruiting their participation in familial cancer registries and clinical and research studies. Funding of this application would provide the opportunity for our TCGC to strengthen our within consortium interactions, to contribute our research experience and expertise to the CGN design and implementation, and to utilize our experience and expertise in recruitment of high risk patients to CGN protocols. The long term goal is to contribute to the identification of cancer susceptibility genes, their mechanisms of action, frequency, penetrance, and genetic or environmental risk modifiers, to integrate this information into optimal patient management, and to assess needs and provide education to address the ethical and psychosocial concerns surrounding human cancer genetics.

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Publications

The psychosocial effects of the Li-Fraumeni Education and Early Detection (LEAD) program on individuals with Li-Fraumeni syndrome.
Authors: Ross J. , Bojadzieva J. , Peterson S. , Noblin S.J. , Yzquierdo R. , Askins M. , Strong L. .
Source: Genetics in medicine : official journal of the American College of Medical Genetics, 2017 09; 19(9), p. 1064-1070.
EPub date: 2017-03-16.
PMID: 28301458
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Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials.
Authors: Skates S.J. , Greene M.H. , Buys S.S. , Mai P.L. , Brown P. , Piedmonte M. , Rodriguez G. , Schorge J.O. , Sherman M. , Daly M.B. , et al. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2017-07-15; 23(14), p. 3628-3637.
EPub date: 2017-01-31.
PMID: 28143870
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Long-term risk of medical conditions associated with breast cancer treatment.
Authors: Hill D.A. , Horick N.K. , Isaacs C. , Domchek S.M. , Tomlinson G.E. , Lowery J.T. , Kinney A.Y. , Berg J.S. , Edwards K.L. , Moorman P.G. , et al. .
Source: Breast cancer research and treatment, 2014 May; 145(1), p. 233-43.
EPub date: 2014-04-03.
PMID: 24696430
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Increased oxidative metabolism in the Li-Fraumeni syndrome.
Authors: Wang P.Y. , Ma W. , Park J.Y. , Celi F.S. , Arena R. , Choi J.W. , Ali Q.A. , Tripodi D.J. , Zhuang J. , Lago C.U. , et al. .
Source: The New England journal of medicine, 2013-03-14; 368(11), p. 1027-32.
PMID: 23484829
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Activating mutation in MET oncogene in familial colorectal cancer.
Authors: Neklason D.W. , Done M.W. , Sargent N.R. , Schwartz A.G. , Anton-Culver H. , Griffin C.A. , Ahnen D.J. , Schildkraut J.M. , Tomlinson G.E. , Strong L.C. , et al. .
Source: BMC cancer, 2011-10-04; 11, p. 424.
EPub date: 2011-10-04.
PMID: 21970370
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Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status.
Authors: Skates S.J. , Mai P. , Horick N.K. , Piedmonte M. , Drescher C.W. , Isaacs C. , Armstrong D.K. , Buys S.S. , Rodriguez G.C. , Horowitz I.R. , et al. .
Source: Cancer prevention research (Philadelphia, Pa.), 2011 Sep; 4(9), p. 1401-8.
PMID: 21893500
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Clinically relevant changes in family history of cancer over time.
Authors: Ziogas A. , Horick N.K. , Kinney A.Y. , Lowery J.T. , Domchek S.M. , Isaacs C. , Griffin C.A. , Moorman P.G. , Edwards K.L. , Hill D.A. , et al. .
Source: JAMA, 2011-07-13; 306(2), p. 172-8.
PMID: 21750294
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Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis.
Authors: Neklason D.W. , Kerber R.A. , Nilson D.B. , Anton-Culver H. , Schwartz A.G. , Griffin C.A. , Lowery J.T. , Schildkraut J.M. , Evans J.P. , Tomlinson G.E. , et al. .
Source: Cancer research, 2008-11-01; 68(21), p. 8993-7.
PMID: 18974144
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Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
Authors: Kerber R.A. , Amos C.I. , Yeap B.Y. , Finkelstein D.M. , Thomas D.C. .
Source: BMC medical genetics, 2008-07-10; 9, p. 64.
EPub date: 2008-07-10.
PMID: 18616822
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Successful strategies for increasing African American participation in cancer genetic studies: hopeful signs for equalizing the benefits of genetic medicine.
Authors: Patterson A.R. , Davis H. , Shelby K. , McCoy J. , Robinson L.D. , Rao S.K. , Banerji P. , Tomlinson G.E. .
Source: Community genetics, 2008; 11(4), p. 208-14.
EPub date: 2008-04-14.
PMID: 18417968
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Assessing BRCA carrier probabilities in extended families.
Authors: Barcenas C.H. , Hosain G.M. , Arun B. , Zong J. , Zhou X. , Chen J. , Cortada J.M. , Mills G.B. , Tomlinson G.E. , Miller A.R. , et al. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-01-20; 24(3), p. 354-60.
PMID: 16421416
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Assay validation for identification of hereditary nonpolyposis colon cancer-causing mutations in mismatch repair genes MLH1, MSH2, and MSH6.
Authors: Hegde M. , Blazo M. , Chong B. , Prior T. , Richards C. .
Source: The Journal of molecular diagnostics : JMD, 2005 Oct; 7(4), p. 525-34.
PMID: 16237223
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Inherited susceptibility for pediatric cancer.
Authors: Plon S.E. , Nathanson K. .
Source: Cancer journal (Sudbury, Mass.), 2005 Jul-Aug; 11(4), p. 255-67.
PMID: 16197716
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Recruitment for breast cancer predisposition studies in an underserved African American population.
Authors: Patterson A. , Davis H. , Euhus D. , Neuhausen S. , Strong L. , Tomlinson G. .
Source: The breast journal, 2005 Jan-Feb; 11(1), p. 79-82.
PMID: 15647088
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Genotype-phenotype correlations in Peutz-Jeghers syndrome.
Authors: Amos C.I. , Keitheri-Cheteri M.B. , Sabripour M. , Wei C. , McGarrity T.J. , Seldin M.F. , Nations L. , Lynch P.M. , Fidder H.H. , Friedman E. , et al. .
Source: Journal of medical genetics, 2004 May; 41(5), p. 327-33.
PMID: 15121768
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Limb girdle muscular dystrophy: use of dHPLC and direct sequencing to detect sarcoglycan gene mutations in a New Zealand cohort.
Authors: Love D.R. .
Source: Clinical genetics, 2004 Jan; 65(1), p. 55-60.
PMID: 15032976
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Primary care physicians' attitudes and practices regarding cancer genetics: a comparison of 2001 with 1996 survey results.
Authors: Friedman L. , Cooper H.P. , Webb J.A. , Weinberg A.D. , Plon S.E. .
Source: Journal of cancer education : the official journal of the American Association for Cancer Education, 2003 Summer; 18(2), p. 91-4.
PMID: 12888383
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Positional identification of microdeletions with genetic markers.
Authors: Amos C.I. , Shete S. , Chen J. , Yu R.K. .
Source: Human heredity, 2003; 56(1-3), p. 107-18.
PMID: 14614244
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Re: On the use of familial aggregation in population-based case probands for calculating penetrance.
Authors: Amos C.I. .
Source: Journal of the National Cancer Institute, 2003-01-01; 95(1), p. 74-5; author reply 77-8.
PMID: 12509406
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Counseling the at risk patient in the BRCA1 and BRCA2 Era.
Authors: Barnes-Kedar I.M. , Plon S.E. .
Source: Obstetrics and gynecology clinics of North America, 2002 Jun; 29(2), p. 341-66, vii.
PMID: 12108833
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Detection of sequence variations in the adenomatous polyposis coli (APC) gene using denaturing high-performance liquid chromatography.
Authors: Wu G. , Wu W. , Hegde M. , Fawkner M. , Chong B. , Love D. , Su L.K. , Lynch P. , Snow K. , Richards C.S. .
Source: Genetic testing, 2001 Winter; 5(4), p. 281-90.
PMID: 11960572
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Mammography behavior after receiving a negative BRCA1 mutation test result in the Ashkenazim: a community-based study.
Authors: Plon S.E. , Peterson L.E. , Friedman L.C. , Richards C.S. .
Source: Genetics in medicine : official journal of the American College of Medical Genetics, 2000 Nov-Dec; 2(6), p. 307-11.
PMID: 11339650
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