||5R01CA074103-04 Interpret this number
||University Of Minnesota Twin Cities
||Molecular Epidemiology of Prostate Carcinogenesis
DESCRIPTION: (Adapted from the Investigator's Abstract) The goals of this
proposed project are to identify risk factors for prostate cancer, to identify
specific genetic and biochemical markers associated with prostate cancer, and
to identify relationships between risk factors and biomarkers. The study will
utilize a case-control design. In-person interviews will be used to collect
data on prostate cancer risk factors such as race, family history, medical
history, diet, alcohol, tobacco use, and occupation (including farming-related
exposures). Blood samples from cases and controls and tissue samples from cases
will be analyzed for biochemical and genetic markers hypothesized to be
associated with prostate cancer. The following specific hypotheses will be
investigated: (1) Increased intake of dietary fat, pesticide exposure, farming,
family history of prostate cancer, or race are associated with prostate cancer
risk. (2) Certain genetic markers are associated with increased frequency based
on exposure variables leading to an increased risk of prostate cancer. (3)
Farming and occupational pesticide exposure are related to increases in the
frequency of loss of heterozygosity of chromosomes 8, 10 , and 17. (4) High
levels of dietary fat intake are associated with high androgen levels. Cases
will be all Minnesota and Wisconsin incident men diagnosed with prostate
cancers, aged 80 or less, over a two-year time period. An equal number of
controls will be selected from state driver's license records and frequency
matched to cases on age and state. Cases and controls under the age of 60 will
serve as the primary group of interest although all cases will be compared to
Quantifying lead-time bias in risk factor studies of cancer through simulation.
, Alexander B.H.
, Anderson K.E.
, Church T.R.
Annals of epidemiology, 2013 Nov; 23(11), p. 735-41.