Grant Number:	5R01CA059736-10 Interpret this number
Primary Investigator:	Malone, Kathleen
Organization:	Fred Hutchinson Cancer Research Center
Project Title:	Factors Affecting Survival of Young Cancer Patients
Fiscal Year:	2002

DESCRIPTION: This application for a competitive renewal of "Factors that affec survival of young breast cancer patients", seeks to extend for five more years the follow-up for recurrence and mortality of a population-based cohort of 128 women who were diagnosed with invasive breast cancer before age 45 during the years 1983 through 1992. These women provide the investigators with a unique opportunity to investigate the interrelationships between epidemiologic risk factor data, tumor characteristics, and breast cancer occurrence and/or mortality in a population-based setting where all cases of breast cancer in a defined geographic area could be assessed, eliminating potential biases impose by studies at referral centers or clinical trials, where women may self-select into the study and not be representative of women in general who get breast cancer. During the past five years, this cohort was followed through follow-up questionnaires and hospital chart reviews, and their tumor specimens were tested for characteristics related to aggressiveness and prognosis. It is important to extend follow-up of this cohort to a minimum of ten years since patient and tumor characteristics may have different relationships with short and long-term mortality. During the next five years, the investigators propose to (a) expand data collection and specimen analyses to the entire cohort (rather than the subgroup of 930 they originally proposed), (b) extend the minimum follow-up period for the entire cohort to ten years, (c) collect updated information on recurrences, treatment, the use of hormone replacement therapy and childbearing after diagnosis, (d) add apoptotic index to the laboratory analyses, and (e) conduct comprehensive analyses of all of these data in relation to mortality and disease-free survival. Young women with many years of potential life to lose who do not fall into clear prognostic categories present a major challenge to clinicians. By gainin an understanding of the association between epidemiologic risk factors and tumor characteristics related to aggressiveness as well as actual risk of recurrence or death, it is possible to develop profiles of women at high risk for aggressive tumors who might benefit from aggressive treatment and of those with low risk tumors for whom such aggressive treatment may not be necessary.




Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Authors: Ong J.S. , An J. , Han X. , Law M.H. , Nandakumar P. , 23andMe Research team , Esophageal cancer consortium , Schumacher J. , Gockel I. , Bohmer A. , et al. .
Source: Gut, 2022 Jun; 71(6), p. 1053-1061.
EPub date: 2021-06-29.
PMID: 34187846
Related Citations

Family history of breast cancer in relation to tumor characteristics and mortality in a population-based study of young women with invasive breast cancer.
Authors: Malone K.E. , Daling J.R. , Doody D.R. , O'Brien C. , Resler A. , Ostrander E.A. , Porter P.L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Dec; 20(12), p. 2560-71.
EPub date: 2011-09-29.
PMID: 21960690
Related Citations

Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.
Authors: Madeleine M.M. , Johnson L.G. , Malkki M. , Resler A.J. , Petersdorf E.W. , McKnight B. , Malone K.E. .
Source: Breast cancer research and treatment, 2011 Oct; 129(3), p. 887-99.
EPub date: 2011-04-27.
PMID: 21523452
Related Citations

Risk factors for triple-negative breast cancer in women under the age of 45 years.
Authors: Dolle J.M. , Daling J.R. , White E. , Brinton L.A. , Doody D.R. , Porter P.L. , Malone K.E. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009 Apr; 18(4), p. 1157-66.
EPub date: 2009-03-31.
PMID: 19336554
Related Citations

Effect of prediagnostic alcohol consumption on survival after breast cancer in young women.
Authors: Reding K.W. , Daling J.R. , Doody D.R. , O'Brien C.A. , Porter P.L. , Malone K.E. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Aug; 17(8), p. 1988-96.
EPub date: 2008-07-29.
PMID: 18664549
Related Citations

Perinatal factors and mortality from breast cancer.
Authors: Sanderson M. , Daling J.R. , Doody D.R. , Malone K.E. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006 Oct; 15(10), p. 1984-7.
PMID: 17035409
Related Citations

Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.
Authors: Friedrichsen D.M. , Malone K.E. , Doody D.R. , Daling J.R. , Ostrander E.A. .
Source: Breast cancer research : BCR, 2004; 6(6), p. R629-35.
EPub date: 2004-09-22.
PMID: 15535844
Related Citations

Epidemiologic and molecular risk factors for contralateral breast cancer among young women.
Authors: Li C.I. , Malone K.E. , Porter P.L. , Daling J.R. .
Source: British journal of cancer, 2003-08-04; 89(3), p. 513-8.
PMID: 12888823
Related Citations

Androgen receptor (CAG)n and (GGC)n polymorphisms and breast cancer risk in a population-based case-control study of young women.
Authors: Suter N.M. , Malone K.E. , Daling J.R. , Doody D.R. , Ostrander E.A. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003 Feb; 12(2), p. 127-35.
PMID: 12582022
Related Citations

The relation of reproductive factors to mortality from breast cancer.
Authors: Daling J.R. , Malone K.E. , Doody D.R. , Anderson B.O. , Porter P.L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002 Mar; 11(3), p. 235-41.
PMID: 11895871
Related Citations

Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma.
Authors: Daling J.R. , Malone K.E. , Doody D.R. , Johnson L.G. , Gralow J.R. , Porter P.L. .
Source: Cancer, 2001-08-15; 92(4), p. 720-9.
PMID: 11550140
Related Citations

Maternal factors and breast cancer risk among young women.
Authors: Sanderson M. , Williams M.A. , Daling J.R. , Holt V.L. , Malone K.E. , Self S.G. , Moore D.E. .
Source: Paediatric and perinatal epidemiology, 1998 Oct; 12(4), p. 397-407.
PMID: 9805713
Related Citations

Validity and reliability of subject and mother reporting of perinatal factors.
Authors: Sanderson M. , Williams M.A. , White E. , Daling J.R. , Holt V.L. , Malone K.E. , Self S.G. , Moore D.E. .
Source: American journal of epidemiology, 1998-01-15; 147(2), p. 136-40.
PMID: 9457002
Related Citations

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients.
Authors: Porter P.L. , Malone K.E. , Heagerty P.J. , Alexander G.M. , Gatti L.A. , Firpo E.J. , Daling J.R. , Roberts J.M. .
Source: Nature medicine, 1997 Feb; 3(2), p. 222-5.
PMID: 9018243
Related Citations