Grant Number:	5R01CA063700-05 Interpret this number
Primary Investigator:	Coons, Teresa
Organization:	St. Mary'S Hospital & Regional Med Ctr
Project Title:	Identification of Lung Cancer Susceptibility Genes
Fiscal Year:	2002

DESCRIPTION: (Adapted from investigator's abstract) The long-term goal of this project is to identify tumor susceptibility genes involved in lung cancer development. There are six specific aims: 1) to generate pedigrees for lung cancer susceptible families; 2) to obtain normal and tumor tissue samples from as many family members as possible; 3) to genotype DNA from family members with appropriate markers; 4) to perform linkage analyses to identify potential loci involved in lung cancer susceptibility; 5) to genotype the entire genome with equally spaced microsatellite markers and perform linkage analysis with these data; and, 6.) if putative loci are localized, to refine the linkage map of the candidate loci.




A second genetic variant on chromosome 15q24-25.1 associates with lung cancer.
Authors: Liu P. , Yang P. , Wu X. , Vikis H.G. , Lu Y. , Wang Y. , Schwartz A.G. , Pinney S.M. , de Andrade M. , Gazdar A. , et al. .
Source: Cancer Research, 2010-04-15 00:00:00.0; 70(8), p. 3128-35.
PMID: 20395203
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Cumulative Effect Of Multiple Loci On Genetic Susceptibility To Familial Lung Cancer
Authors: Liu P. , Vikis H.G. , Lu Y. , Wang Y. , Schwartz A.G. , Pinney S.M. , Yang P. , de Andrade M. , Gazdar A. , Gaba C. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2010 Feb; 19(2), p. 517-24.
PMID: 20142248
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Haplotype And Cell Proliferation Analyses Of Candidate Lung Cancer Susceptibility Genes On Chromosome 15q24-25.1
Authors: Liu Y. , Liu P. , Wen W. , James M.A. , Wang Y. , Bailey-Wilson J.E. , Amos C.I. , Pinney S.M. , Yang P. , de Andrade M. , et al. .
Source: Cancer Research, 2009-10-01 00:00:00.0; 69(19), p. 7844-50.
PMID: 19789337
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Fine Mapping Of Chromosome 6q23-25 Region In Familial Lung Cancer Families Reveals Rgs17 As A Likely Candidate Gene
Authors: You M. , Wang D. , Liu P. , Vikis H. , James M. , Lu Y. , Wang Y. , Wang M. , Chen Q. , Jia D. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2009-04-15 00:00:00.0; 15(8), p. 2666-74.
PMID: 19351763
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Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.
Authors: Liu P. , Vikis H.G. , Wang D. , Lu Y. , Wang Y. , Schwartz A.G. , Pinney S.M. , Yang P. , de Andrade M. , Petersen G.M. , et al. .
Source: Journal Of The National Cancer Institute, 2008-09-17 00:00:00.0; 100(18), p. 1326-30.
EPub date: 2008-09-17 00:00:00.0.
PMID: 18780872
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