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Grant Details

Grant Number: 5R01CA063700-05 Interpret this number
Primary Investigator: Coons, Teresa
Organization: St. Mary'S Hospital & Regional Med Ctr
Project Title: Identification of Lung Cancer Susceptibility Genes
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Adapted from investigator's abstract) The long-term goal of this project is to identify tumor susceptibility genes involved in lung cancer development. There are six specific aims: 1) to generate pedigrees for lung cancer susceptible families; 2) to obtain normal and tumor tissue samples from as many family members as possible; 3) to genotype DNA from family members with appropriate markers; 4) to perform linkage analyses to identify potential loci involved in lung cancer susceptibility; 5) to genotype the entire genome with equally spaced microsatellite markers and perform linkage analysis with these data; and, 6.) if putative loci are localized, to refine the linkage map of the candidate loci.

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Publications

A second genetic variant on chromosome 15q24-25.1 associates with lung cancer.
Authors: Liu P. , Yang P. , Wu X. , Vikis H.G. , Lu Y. , Wang Y. , Schwartz A.G. , Pinney S.M. , de Andrade M. , Gazdar A. , et al. .
Source: Cancer research, 2010-04-15; 70(8), p. 3128-35.
PMID: 20395203
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Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer.
Authors: Liu P. , Vikis H.G. , Lu Y. , Wang Y. , Schwartz A.G. , Pinney S.M. , Yang P. , de Andrade M. , Gazdar A. , Gaba C. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010 Feb; 19(2), p. 517-24.
PMID: 20142248
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Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1.
Authors: Liu Y. , Liu P. , Wen W. , James M.A. , Wang Y. , Bailey-Wilson J.E. , Amos C.I. , Pinney S.M. , Yang P. , de Andrade M. , et al. .
Source: Cancer research, 2009-10-01; 69(19), p. 7844-50.
EPub date: 2009-09-29.
PMID: 19789337
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Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.
Authors: You M. , Wang D. , Liu P. , Vikis H. , James M. , Lu Y. , Wang Y. , Wang M. , Chen Q. , Jia D. , et al. .
Source: Clinical cancer research : an official journal of the American Association for Cancer Research, 2009-04-15; 15(8), p. 2666-74.
EPub date: 2009-04-07.
PMID: 19351763
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Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.
Authors: Liu P. , Vikis H.G. , Wang D. , Lu Y. , Wang Y. , Schwartz A.G. , Pinney S.M. , Yang P. , de Andrade M. , Petersen G.M. , et al. .
Source: Journal of the National Cancer Institute, 2008-09-17; 100(18), p. 1326-30.
EPub date: 2008-09-09.
PMID: 18780872
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