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Grant Details

Grant Number: 5R01CA086007-02 Interpret this number
Primary Investigator: Stuver, Sherri
Organization: Harvard University (Sch Of Public Hlth)
Project Title: Perinatal and Adolescent Factors in Breast Cancer
Fiscal Year: 2002
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Abstract

DESCRIPTION: The epidemiology of breast cancer is complicated and only partially understood, despite a concerted research effort in this area. The primary goal of the proposed study is to examine the association between, on the one hand, perinatal factors that exhibit their hypothesized carcinogenic action during early life and, on the other established breast cancer risk factors that operate during the perimenarcheal years. Our objective will be to explore whether certain perinatal factors may share a common biologic mechanism of action with perimenarcheal risk factors, with respect to breast carcinogenesis. The meet this objective, the following specific aims will be addressed to investigate if there is an association between birth size and indicators of sexual maturity during adolescence, particularly age at menarche and breast development; to study the association between birth size and adolescent somatic growth; to examine the association between perinatal complications, such as pregnancy pre-eclampsia/eclampsia, jaundice, and prematurity, and indicators of sexual maturity and somatic growth during adolescence. To study these relationships, a retrospective cohort study of the association between perinatal and adolescent factors will be conducted among young girls in Nord Trondelag County in Norway. The population based for this study will be the nearly 5,000 girls, 13 to 19 years of age, who were born between 1977 and 1984 and who participated in general health survey for adolescents that took place in 1996 and 1997. Using the unique personal registration number assigned to all Norwegians, linkage will be made between the relevant information collected during the adolescent health survey and birth record information stored in the national Birth Registry. Access to data of such excellent quality will provide an important opportunity to examine the role of perinatal and perimenarcheal factors in the etiology of breast cancer.

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Publications

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.
Authors: Luke C.J. , Pak S.C. , Askew Y.S. , Naviglia T.L. , Askew D.J. , Nobar S.M. , Vetica A.C. , Long O.S. , Watkins S.C. , Stolz D.B. , et al. .
Source: Cell, 2007-09-21; 130(6), p. 1108-19.
PMID: 17889653
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The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases.
Authors: Pak S.C. , Tsu C. , Luke C.J. , Askew Y.S. , Silverman G.A. .
Source: Biochemistry, 2006-04-11; 45(14), p. 4474-80.
PMID: 16584183
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Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin.
Authors: Cole E.B. , Miller D. , Rometo D. , Greenberg R.M. , Brömme D. , Cataltepe S. , Pak S.C. , Mills D.R. , Silverman G.A. , Luke C.J. .
Source: Biochemistry, 2004-09-21; 43(37), p. 11750-9.
PMID: 15362859
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Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.
Authors: Askew D.J. , Askew Y.S. , Kato Y. , Turner R.F. , Dewar K. , Lehoczky J. , Silverman G.A. .
Source: Genomics, 2004 Jul; 84(1), p. 176-84.
PMID: 15203215
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The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.
Authors: Askew D.J. , Askew Y.S. , Kato Y. , Luke C.J. , Pak S.C. , Brömme D. , Silverman G.A. .
Source: Genomics, 2004 Jul; 84(1), p. 166-75.
PMID: 15203214
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SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.
Authors: Pak S.C. , Kumar V. , Tsu C. , Luke C.J. , Askew Y.S. , Askew D.J. , Mills D.R. , Brömme D. , Silverman G.A. .
Source: The Journal of biological chemistry, 2004-04-09; 279(15), p. 15448-59.
EPub date: 2004-01-22.
PMID: 14739286
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Birth size in relation to age at menarche and adolescent body size: implications for breast cancer risk.
Authors: Romundstad P.R. , Vatten L.J. , Nilsen T.I. , Holmen T.L. , Hsieh C.C. , Trichopoulos D. , Stuver S.O. .
Source: International journal of cancer, 2003-06-20; 105(3), p. 400-3.
PMID: 12704676
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