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Grant Details

Grant Number: 5R29CA078293-05 Interpret this number
Primary Investigator: Ma, Jing
Organization: Brigham And Women'S Hospital
Project Title: Iron Status and Risk of Chd and Colon Cancer
Fiscal Year: 2002
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Abstract

DESCRIPTION: (Adapted from Investigator's Abstract) The investigators propose to examine prospectively the relation between iron status (intake, body stores, and genetic susceptibility for hemochromatosis) and risk of myocardial infarction (MI) and colorectal cancer in three large cohorts. Iron intake was assessed by semiquantitative food frequency questionnaire (SFFQ) in 1980 in the Nurses' Health Study (NHS, n=121,700 women) and in 1986 in the NHS and in the Health Professionals Follow-up Study (HPFS, n=51,529 men). Blood samples were collected in both of these cohorts: from the NHS in 1989-90 (n=32,825 women), and the HPFS in 1993-94 (n=18,000 men). In addition, samples also were collected from participants in the Physicians' Health Study in 1982 (PHS, n=14,916 men). These men and women initially free of cardiovascular disease and cancer and have been followed prospectively for the occurrence of cardiovascular disease and cancer. The investigators plan to assay the samples, in a nested case-control design, for biomarkers of body iron stores (iron, total iron binding capacity, ferritin) and genetic marker of hemochromatosis, an inherited disease of iron overload (C282Y, a missense mutation in HLA-H gene). The iron-CHD/cancer hypotheses have been supported by laboratory and animal studies, but findings from small, less comprehensive epidemiologic studies are inconsistent. They propose to evaluate the individual associations of intake, biomarker levels, and genotype with risk of MI and colorectal cancer, as well as the combined effects. Further, they will evaluate other dietary and lifestyle factors that may account for or modify the association between iron and MI/colorectal cancer. The ongoing three cohorts will provide high yield follow-up participation and high quality end-point verification in addition to information on important variables (e.g., smoking, vitamin supplement use, dietary factors) for the proposed study. These analyses will take advantage of existing blood banks of these well-characterized cohorts, and part of the plasma ferritin measurements (the NHS and PHS) are funded through other sources. The investigators state that hence, this application provides a well-focused, efficient cost-effective, and comprehensive approach to evaluate the hypothesized but unproven role of iron as a risk factor for future cardiovascular disease and cancer.

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Publications

Excessive body iron stores are not associated with risk of coronary heart disease in women.
Authors: Sun Q. , Ma J. , Rifai N. , Franco O.H. , Rexrode K.M. , Hu F.B. .
Source: The Journal of nutrition, 2008 Dec; 138(12), p. 2436-41.
PMID: 19022969
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Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis.
Authors: Ma J. , Li H. , Giovannucci E. , Mucci L. , Qiu W. , Nguyen P.L. , Gaziano J.M. , Pollak M. , Stampfer M.J. .
Source: The Lancet. Oncology, 2008 Nov; 9(11), p. 1039-47.
EPub date: 2008-10-03.
PMID: 18835745
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Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy.
Authors: Grodstein F. , Manson J.E. , Stampfer M.J. , Rexrode K. .
Source: Archives of internal medicine, 2008-04-28; 168(8), p. 861-6.
PMID: 18443262
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Vitamin B-12 deficiency is prevalent in 35- to 64-year-old Chinese adults.
Authors: Hao L. , Ma J. , Zhu J. , Stampfer M.J. , Tian Y. , Willett W.C. , Li Z. .
Source: The Journal of nutrition, 2007 May; 137(5), p. 1278-85.
PMID: 17449593
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High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status.
Authors: Hao L. , Ma J. , Zhu J. , Stampfer M.J. , Tian Y. , Willett W.C. , Li Z. .
Source: The Journal of nutrition, 2007 Feb; 137(2), p. 407-13.
PMID: 17237319
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A prospective study of folate intake and the risk of pancreatic cancer in men and women.
Authors: Skinner H.G. , Michaud D.S. , Giovannucci E.L. , Rimm E.B. , Stampfer M.J. , Willett W.C. , Colditz G.A. , Fuchs C.S. .
Source: American journal of epidemiology, 2004-08-01; 160(3), p. 248-58.
PMID: 15257998
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Apolipoprotein(a) size and lipoprotein(a) concentration and future risk of angina pectoris with evidence of severe coronary atherosclerosis in men: The Physicians' Health Study.
Authors: Rifai N. , Ma J. , Sacks F.M. , Ridker P.M. , Hernandez W.J. , Stampfer M.J. , Marcovina S.M. .
Source: Clinical chemistry, 2004 Aug; 50(8), p. 1364-71.
EPub date: 2004-05-20.
PMID: 15155542
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Prospective study of plasma carotenoids and tocopherols in relation to risk of ischemic stroke.
Authors: Hak A.E. , Ma J. , Powell C.B. , Campos H. , Gaziano J.M. , Willett W.C. , Stampfer M.J. .
Source: Stroke, 2004 Jul; 35(7), p. 1584-8.
EPub date: 2004-06-03.
PMID: 15178820
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A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer.
Authors: Ewart-Toland A. , Chan J.M. , Yuan J. , Balmain A. , Ma J. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2004 May; 13(5), p. 759-64.
PMID: 15159307
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A prospective study of plasma C-peptide and colorectal cancer risk in men.
Authors: Ma J. , Giovannucci E. , Pollak M. , Leavitt A. , Tao Y. , Gaziano J.M. , Stampfer M.J. .
Source: Journal of the National Cancer Institute, 2004-04-07; 96(7), p. 546-53.
PMID: 15069117
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Body iron stores in relation to risk of type 2 diabetes in apparently healthy women.
Authors: Jiang R. , Manson J.E. , Meigs J.B. , Ma J. , Rifai N. , Hu F.B. .
Source: JAMA, 2004-02-11; 291(6), p. 711-7.
PMID: 14871914
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Body iron stores and their determinants in healthy postmenopausal US women.
Authors: Liu J.M. , Hankinson S.E. , Stampfer M.J. , Rifai N. , Willett W.C. , Ma J. .
Source: The American journal of clinical nutrition, 2003 Dec; 78(6), p. 1160-7.
PMID: 14668279
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Geographical, seasonal and gender differences in folate status among Chinese adults.
Authors: Hao L. , Ma J. , Stampfer M.J. , Ren A. , Tian Y. , Tang Y. , Willett W.C. , Li Z. .
Source: The Journal of nutrition, 2003 Nov; 133(11), p. 3630-5.
PMID: 14608086
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Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians.
Authors: Hak A.E. , Stampfer M.J. , Campos H. , Sesso H.D. , Gaziano J.M. , Willett W. , Ma J. .
Source: Circulation, 2003-08-19; 108(7), p. 802-7.
EPub date: 2003-08-04.
PMID: 12900344
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Association between the Met326Ile polymorphism of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase and prostate cancer risk: a prospective study.
Authors: Paradis A.E. , Kantoff P.W. , Giovannucci E. , Stampfer M.J. , Ma J. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003 Feb; 12(2), p. 172-3.
PMID: 12582030
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Body iron stores and coronary heart disease.
Authors: Ma J. , Stampfer M.J. .
Source: Clinical chemistry, 2002; 48(4), p. 601-3.
PMID: 11901057
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Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men.
Authors: Ma J. , Giovannucci E. , Pollak M. , Chan J.M. , Gaziano J.M. , Willett W. , Stampfer M.J. .
Source: Journal of the National Cancer Institute, 2001-09-05; 93(17), p. 1330-6.
PMID: 11535708
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Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3.
Authors: Ma J. , Pollak M.N. , Giovannucci E. , Chan J.M. , Tao Y. , Hennekens C.H. , Stampfer M.J. .
Source: Journal of the National Cancer Institute, 1999-04-07; 91(7), p. 620-5.
PMID: 10203281
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