Grant Details

**Grant Number:** |
5R01CA057253-09 Interpret this number |

**Primary Investigator:** |
Gray, Robert |

**Organization:** |
Dana-Farber Cancer Institute |

**Project Title:** |
Modeling Failure Time Data in Cancer Research |

**Fiscal Year:** |
2002 |

Abstract

This project will develop and investigate new methodology for analyzing data from clinical studies of cancer and other chromic diseases. During this grant period methods for analyzing clustered failure time data will be emphasized. The specific areas of concentration are as follows: 1. Methods for the analysis of association structured in clustered failure time data. Clustered data might arise, for example, if there are institutional effects in multicenter clinical trials. Methods for non- parametric estimation of the association structure, methods for using these estimates to examine the association structure and help guide formulation of association models, and methods for local estimation of association parameters over time, will be investigated.. Estimates of association structure will also be applied to the problems of estimating weight matrices and variances of estimated parameters in transformed linear marginal regression analyses, and possibly other models as well. 2. Methods for semiparametric analysis of transformed linear failure time models with clustered data. Numerical issues, appropriate choice of weight functions, and methods for inference for rank based estimating equations will be addressed.

Publications

**Weighted estimating equations for linear regression analysis of clustered failure time data.**
**Authors:** Gray R.J.
.

**Source:** Lifetime data analysis, 2003 Jun; 9(2), p. 123-38.

**PMID:** 12735492

Related Citations
**Modeling spatial survival data using semiparametric frailty models.**
**Authors:** Li Y.
, Ryan L.
.

**Source:** Biometrics, 2002 Jun; 58(2), p. 287-97.

**PMID:** 12071401

Related Citations
**The use of frailty hazard models for unrecognized heterogeneity that interacts with treatment: considerations of efficiency and power.**
**Authors:** Li Y.
, Betensky R.A.
, Louis D.N.
, Cairncross J.G.
.

**Source:** Biometrics, 2002 Mar; 58(1), p. 232-6.

**PMID:** 11890320

Related Citations
**Optimal weight functions for marginal proportional hazards analysis of clustered failure time data.**
**Authors:** Gray R.J.
, Li Y.
.

**Source:** Lifetime data analysis, 2002 Mar; 8(1), p. 5-19.

**PMID:** 11878224

Related Citations
**Estimation of regression parameters and the hazard function in transformed linear survival models.**
**Authors:** Gray R.J.
.

**Source:** Biometrics, 2000 Jun; 56(2), p. 571-6.

**PMID:** 10877318

Related Citations
**GEE with Gaussian estimation of the correlations when data are incomplete.**
**Authors:** Lipsitz S.R.
, Molenberghs G.
, Fitzmaurice G.M.
, Ibrahim J.
.

**Source:** Biometrics, 2000 Jun; 56(2), p. 528-36.

**PMID:** 10877313

Related Citations
**A global goodness-of-fit statistic for Cox regression models.**
**Authors:** Parzen M.
, Lipsitz S.R.
.

**Source:** Biometrics, 1999 Jun; 55(2), p. 580-4.

**PMID:** 11318217

Related Citations
**Likelihood methods for incomplete longitudinal binary responses with incomplete categorical covariates.**
**Authors:** Lipsitz S.R.
, Ibrahim J.G.
, Fitzmaurice G.M.
.

**Source:** Biometrics, 1999 Mar; 55(1), p. 214-23.

**PMID:** 11318157

Related Citations
**Estimating equations with incomplete categorical covariates in the Cox model.**
**Authors:** Lipsitz S.R.
, Ibrahim J.G.
.

**Source:** Biometrics, 1998 Sep; 54(3), p. 1002-13.

**PMID:** 9750248

Related Citations
**Inference using conditional logistic regression with missing covariates.**
**Authors:** Lipsitz S.R.
, Parzen M.
, Ewell M.
.

**Source:** Biometrics, 1998 Mar; 54(1), p. 295-303.

**PMID:** 9544523

Related Citations
**Tests for homogeneity of the risk difference when data are sparse.**
**Authors:** Lipsitz S.R.
, Dear K.B.
, Laird N.M.
, Molenberghs G.
.

**Source:** Biometrics, 1998 Mar; 54(1), p. 148-60.

**PMID:** 9544513

Related Citations
**On tests for group variation with a small to moderate number of groups.**
**Authors:** Gray R.J.
.

**Source:** Lifetime data analysis, 1998; 4(2), p. 139-48.

**PMID:** 9658772

Related Citations
**Parameter estimation from incomplete data in binomial regression when the missing data mechanism is nonignorable.**
**Authors:** Ibrahim J.G.
, Lipsitz S.R.
.

**Source:** Biometrics, 1996 Sep; 52(3), p. 1071-8.

**PMID:** 8805768

Related Citations
**Estimating equations for measures of association between repeated binary responses.**
**Authors:** Lipsitz S.R.
, Fitzmaurice G.M.
.

**Source:** Biometrics, 1996 Sep; 52(3), p. 903-12.

**PMID:** 8805760

Related Citations
**A Bayesian analysis of institutional effects in a multicenter cancer clinical trial.**
**Authors:** Gray R.J.
.

**Source:** Biometrics, 1994 Mar; 50(1), p. 244-53.

**PMID:** 8086608

Related Citations