Grant Details
Grant Number: |
1R03CA094770-01 Interpret this number |
Primary Investigator: |
Chiu, Brian |
Organization: |
University Of Nebraska Medical Center |
Project Title: |
Case-Control Study of Pesticides and T(14;18) Lymphoma |
Fiscal Year: |
2002 |
Abstract
DESCRIPTION (provided by applicant):
A population-based, case-control study of non-Hodgkin's lymphoma (NHL) was
conducted in Nebraska between 1983 and 1986. This NCI's study collected
extensive information on agricultural exposures. Herein, an ancillary
molecular study is proposed to determine the role of pesticides in the
occurrence of t(14;18) chromosomal translocation in this case-control study.
An association between NHL and pesticides has been observed repeatedly, but
not consistently. Results of epidemiologic studies of pesticides and NHL may
be obscured by the aggregate evaluation of cases that are etiologically
diverse. The t(14;18) is the most common cytogenetic abnormality, and
t(14;18)-mediated constitutive overexpression of BCL2 protein is an important
early event in NHL pathogenesis. The current proposal will classify NHL cases
according to t(14;18) status to identify agricultural risk factors that may be
specifically associated with t(14;18)-positive or -negative pathogenic
mechanisms. The specific aims are to 1) obtain paraffin-embedded tumor blocks
for NHL cases; 2) determine the presence of the t(14;18) translocation; and 3)
investigate pesticides for their association with t(14;18)-positive NHL or
t(14;18)-negative NHL. The hypothesis is that pesticides act specifically
along a t(14;18)-dependent pathway, resulting in stronger associations with
t(14;18)-positive than t(14;18)-negative NHL. The research design is a
molecular case-control study. Tumor blocks will be obtained from the Lymphoma
Registry Tissue Bank for all NHL cases in the original case-control study
(about 270-290 tissue blocks will be available). Fluorescence in-situ
hybridization (FISH) analysis will be used to determine the presence of the
t(14;18) translocation. Results from FISH analyses will be used to classify
NHL cases into t(14;18)-positive NHL or t(14;18)-negative NHL. Logistic
regression models will be used to calculate the odds ratios for
t(14;18)-positive NHL and t(14;18)-negative NHL associated with various groups
and types of pesticides. The low-term objective is to improve understanding of
the disease process which may ultimately lead to improved prevention of NHL in
the general population.
Publications
Dietary patterns and the risk of non-Hodgkin lymphoma.
Authors: Ollberding N.J.
, Aschebrook-Kilfoy B.
, Caces D.B.
, Smith S.M.
, Weisenburger D.D.
, Chiu B.C.
.
Source: Public Health Nutrition, 2014 Jul; 17(7), p. 1531-7.
PMID: 23659580
Related Citations
Dietary intake of fruits and vegetables and overall survival in non-Hodgkin lymphoma.
Authors: Ollberding N.J.
, Aschebrook-Kilfoy B.
, Caces D.B.
, Smith S.M.
, Weisenburger D.D.
, Chiu B.C.
.
Source: Leukemia & Lymphoma, 2013 Dec; 54(12), p. 2613-9.
PMID: 23488609
Related Citations
Pre-diagnosis cigarette smoking and overall survival in non-Hodgkin lymphoma.
Authors: Ollberding N.J.
, Evens A.M.
, Aschebrook-Kilfoy B.
, Caces D.B.
, Weisenburger D.D.
, Smith S.M.
, Chiu B.C.
.
Source: British Journal Of Haematology, 2013 Nov; 163(3), p. 352-6.
PMID: 23909494
Related Citations
An upward trend in the age-specific incidence patterns for mantle cell lymphoma in the USA.
Authors: Aschebrook-Kilfoy B.
, Caces D.B.
, Ollberding N.J.
, Smith S.M.
, Chiu B.C.
.
Source: Leukemia & Lymphoma, 2013 Aug; 54(8), p. 1677-83.
PMID: 23350889
Related Citations
Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma.
Authors: Aschebrook-Kilfoy B.
, Ward M.H.
, Dave B.J.
, Smith S.M.
, Weisenburger D.D.
, Chiu B.C.
.
Source: Leukemia & Lymphoma, 2013 May; 54(5), p. 945-50.
PMID: 23013327
Related Citations
Phytanic acid and the risk of non-Hodgkin lymphoma.
Authors: Ollberding N.J.
, Aschebrook-Kilfoy B.
, Caces D.B.
, Wright M.E.
, Weisenburger D.D.
, Smith S.M.
, Chiu B.C.
.
Source: Carcinogenesis, 2013 Jan; 34(1), p. 170-5.
PMID: 23042099
Related Citations
Meat intake and risk of non-Hodgkin lymphoma.
Authors: Aschebrook-Kilfoy B.
, Ollberding N.J.
, Kolar C.
, Lawson T.A.
, Smith S.M.
, Weisenburger D.D.
, Chiu B.C.
.
Source: Cancer Causes & Control : Ccc, 2012 Oct; 23(10), p. 1681-92.
PMID: 22890783
Related Citations
Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma.
Authors: Chiu B.C.
, Kwon S.
, Evens A.M.
, Surawicz T.
, Smith S.M.
, Weisenburger D.D.
.
Source: Cancer Causes & Control : Ccc, 2011 Aug; 22(8), p. 1183-95.
PMID: 21695384
Related Citations
Pesticides, chromosomal aberrations, and non-Hodgkin's lymphoma.
Authors: Chiu B.C.
, Blair A.
.
Source: Journal Of Agromedicine, 2009; 14(2), p. 250-5.
PMID: 19437285
Related Citations
Dietary factors and risk of t(14;18)-defined subgroups of non-Hodgkin lymphoma.
Authors: Chiu B.C.
, Dave B.J.
, Ward M.H.
, Fought A.J.
, Hou L.
, Jain S.
, Gapstur S.
, Evens A.M.
, Zahm S.H.
, Blair A.
, et al.
.
Source: Cancer Causes & Control : Ccc, 2008 Oct; 19(8), p. 859-67.
PMID: 18386141
Related Citations
The utility of t(14;18) in understanding risk factors for non-Hodgkin lymphoma.
Authors: Chiu B.C.
, Lan Q.
, Dave B.J.
, Blair A.
, Zahm S.H.
, Weisenburger D.D.
.
Source: Journal Of The National Cancer Institute. Monographs, 2008; (39), p. 69-73.
PMID: 18648007
Related Citations
Cigarette smoking, familial hematopoietic cancer, hair dye use, and risk of t(14;18)-defined subtypes of non-Hodgkin's lymphoma.
Authors: Chiu B.C.
, Dave B.J.
, Blair A.
, Gapstur S.M.
, Chmiel J.S.
, Fought A.J.
, Zahm S.H.
, Weisenburger D.D.
.
Source: American Journal Of Epidemiology, 2007-03-15 00:00:00.0; 165(6), p. 652-9.
EPub date: 2007-03-15 00:00:00.0.
PMID: 17204518
Related Citations
Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma.
Authors: Chiu B.C.
, Dave B.J.
, Blair A.
, Gapstur S.M.
, Zahm S.H.
, Weisenburger D.D.
.
Source: Blood, 2006-08-15 00:00:00.0; 108(4), p. 1363-9.
EPub date: 2006-08-15 00:00:00.0.
PMID: 16621961
Related Citations