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Grant Details

Grant Number: 2R01CA059039-27 Interpret this number
Primary Investigator: Efron, Bradley
Organization: Stanford University
Project Title: Adaptation of New Statistical Ideas for Medicine
Fiscal Year: 2002


DESCRIPTION (provided by applicant): Biostatistical methodology is in a race to keep up with the massive databases being accumulated by new biomedical technologies. The long-term purpose of this grant has been to shorten the transfer time between modern statistical theory and its successful application to practice. The three new projects proposed here each use computer-intensive theoretical ideas to attack a difficult applications area: empirical Bayes methods for the analysis of microarray data; two way proportional hazards modeling for disentangling complicated survival situations that arise in cancer and HIV studies; and new permutation and bootstrap methods for assessing genotype-phenotype relationships in large association studies.


In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis.
Authors: Rath B.A. , Yousef K.P. , Katzenstein D.K. , Shafer R.W. , Schütte C. , von Kleist M. , Merigan T.C. .
Source: PloS one, 2013; 8(4), p. e61102.
EPub date: 2013-04-17.
PMID: 23613794
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Persistence versus reversion of 3TC resistance in HIV-1 determine the rate of emergence of NVP resistance.
Authors: Rath B.A. , Olshen R.A. , Halpern J. , Merigan T.C. .
Source: Viruses, 2012 Aug; 4(8), p. 1212-34.
EPub date: 2012-08-07.
PMID: 23012621
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Intracellular reduction of selenite into glutathione peroxidase. Evidence for involvement of NADPH and not glutathione as the reductant.
Authors: Bhamre S. , Nuzzo R.L. , Whitin J.C. , Olshen R.A. , Cohen H.J. .
Source: Molecular and cellular biochemistry, 2000 Aug; 211(1-2), p. 9-17.
PMID: 11055542
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Clustering and the design of preference-assessment surveys in healthcare.
Authors: Lin A. , Lenert L.A. , Hlatky M.A. , McDonald K.M. , Olshen R.A. , Hornberger J. .
Source: Health services research, 1999 Dec; 34(5 Pt 1), p. 1033-45.
PMID: 10591271
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Empirically defined health states for depression from the SF-12.
Authors: Sugar C.A. , Sturm R. , Lee T.T. , Sherbourne C.D. , Olshen R.A. , Wells K.B. , Lenert L.A. .
Source: Health services research, 1998 Oct; 33(4 Pt 1), p. 911-28.
PMID: 9776942
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Modeling of progressive glomerular injury in humans with lupus nephritis.
Authors: Buckheit J.B. , Olshen R.A. , Blouch K. , Myers B.D. .
Source: The American journal of physiology, 1997 Jul; 273(1 Pt 2), p. F158-69.
PMID: 9249604
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Bootstrap confidence levels for phylogenetic trees.
Authors: Efron B. , Halloran E. , Holmes S. .
Source: Proceedings of the National Academy of Sciences of the United States of America, 1996-11-12; 93(23), p. 13429-34.
PMID: 8917608
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Covariability of V3 loop amino acids.
Authors: Bickel P.J. , Cosman P.C. , Olshen R.A. , Spector P.C. , Rodrigo A.G. , Mullins J.I. .
Source: AIDS research and human retroviruses, 1996-10-10; 12(15), p. 1401-11.
PMID: 8893048
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Bootstrap confidence levels for phylogenetic trees.
Authors: Efron B. , Halloran E. , Holmes S. .
Source: Proceedings of the National Academy of Sciences of the United States of America, 1996-07-09; 93(14), p. 7085-90.
PMID: 8692949
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In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects.
Authors: Lech W.J. , Wang G. , Yang Y.L. , Chee Y. , Dorman K. , McCrae D. , Lazzeroni L.C. , Erickson J.W. , Sinsheimer J.S. , Kaplan A.H. .
Source: Journal of virology, 1996 Mar; 70(3), p. 2038-43.
PMID: 8627733
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Designing a cost-effective clinical trial.
Authors: Hornberger J.C. , Brown B.W. , Halpern J. .
Source: Statistics in medicine, 1995-10-30; 14(20), p. 2249-59.
PMID: 8552901
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