Grant Number:	5R01HG002241-02 Interpret this number
Primary Investigator:	Kinney, Anita
Organization:	University Of Utah
Project Title:	BRCA1 Testing in a Large African American Kindred
Fiscal Year:	2001

This project proposes to address a critical gap in the literature regarding cancer susceptibility testing by examining utilization of genetic counseling and testing, and behavioral and psychosocial responses to the receipt of genetic information among a large, extended African American kindred (K2099) linked to a specific BRCA1 mutation. Information derived from this study may guide clinical interventions that help promote adherence to cancer prevention and screening guidelines for BRCAl mutation carriers and noncarriers and prevent psychosocial dysflmction related to receiving genetic information among families with characteristics similar to K2099. The findings from this study may also be translated into culturally appropriate interventions to promote healthy behaviors and coping. Female BRCA1 mutation carriers have a very high risk of developing breast or ovarian cancer. Male carriers are at an increased risk for prostate cancer and may transmit the BRCA1 mutation to their offspring. A prospective study of approximately 150 members of K2099 and their spouses/partners will be performed over a four year period. Genetic education and counseling will be provided when testing is offered and at the results session. Data will be collected through detailed questionnaires before and after testing on a wide range of behavioral and psychosocial measures. The specific aims are to: (1) identify predictors of the decision to choose or decline genetic counseling and testing services; (2) examine the attitudes towards BRCA1 testing among spouses/partners of adult female and male kindred members and determine how they influence BRCAl testing decisions; (3) evaluate the effects of genetic counseling and testing for BRCA1 mutations on psychological and social well being of kindred members and their spouses/partners; (4) identify how genetic counseling and testing, and knowledge of BRCA1 mutation carrier status influences utilization of health services and health behaviors among adult women and men; and (5) describe facilitators and barriers to genetic counseling and testing and utilization of screening and preventive measures for BRCA1 mutation-linked cancers.




Exploring Attitudes, Beliefs, And Communication Preferences Of Latino Community Members Regarding Brca1/2 Mutation Testing And Preventive Strategies
Authors: Kinney,A.Y. , Gammon,A. , Coxworth,J. , Simonsen,S.E. , Arce-Laretta,M. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2010 Feb; 12(2), p. 105-15.
PMID: 20061960
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Religiosity, Spirituality, And Psychological Distress In African-americans At Risk For Having A Hereditary Cancer Predisposing Gene Mutation
Authors: Kinney,A.Y. , Coxworth,J.E. , Simonson,S.E. , Fanning,J.B. .
Source: American Journal Of Medical Genetics. Part C, Seminars In Medical Genetics, 2009-02-15 00:00:00.0; 151C(1), p. 13-21.
PMID: 19170079
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Genetic counseling communication with an African American BRCA1 kindred.
Authors: Ellington L. , Maxwel A. , Baty B.J. , Roter D. , Dudley W.N. , Kinney A.Y. .
Source: Social Science & Medicine (1982), 2007 Feb; 64(3), p. 724-34.
PMID: 17081667
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Uncertainty In Brca1 Cancer Susceptibility Testing
Authors: Baty,B.J. , Dudley,W.N. , Musters,A. , Kinney,A.Y. .
Source: American Journal Of Medical Genetics. Part C, Seminars In Medical Genetics, 2006-11-15 00:00:00.0; 142C(4), p. 241-50.
PMID: 17068806
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Risk Reduction Behaviors And Provider Communication Following Genetic Counseling And Brca1 Mutation Testing In An African American Kindred
Authors: Kinney A.Y. , Simonsen S.E. , Baty B.J. , Mandal D. , Neuhausen S.L. , Seggar K. , Holubkov R. , Bloor L. , Smith K. .
Source: Journal Of Genetic Counseling, 2006 Aug; 15(4), p. 293-305.
PMID: 16865561
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Acceptance Of Genetic Testing For Hereditary Breast Ovarian Cancer Among Study Enrollees From An African American Kindred
Authors: Kinney A.Y. , Simonsen S.E. , Baty B.J. , Mandal D. , Neuhausen S.L. , Seggar K. , Holubkov R. , Smith K. .
Source: American Journal Of Medical Genetics. Part A, 2006-04-15 00:00:00.0; 140(8), p. 813-26.
PMID: 16523520
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The Impact Of Receiving Genetic Test Results On General And Cancer-specific Psychologic Distress Among Members Of An African-american Kindred With A Brca1 Mutation
Authors: Kinney A.Y. , Bloor L.E. , Mandal D. , Simonsen S.E. , Baty B.J. , Holubkov R. , Seggar K. , Neuhausen S. , Smith K. .
Source: Cancer, 2005-12-01 00:00:00.0; 104(11), p. 2508-16.
PMID: 16222692
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