DESCRIPTION (Applicant's Description) Most colorectal cancers arise from
adenomatous polyps, and a large proportion of adenoma patients will develop
new adenomas after their initial polypectomy. This application is to evaluate
tumor markers in the initial adenomas as potential predictors of adenoma
recurrence in 300 adenoma patients recruited as part of an existing NCI-funded
follow-up study (RO1 CA72784). In addition to the markers (t)53
over-expression and mutation, K-ras mutation, and Ki-67 labeling index)
evaluated in the parent study, we propose in this application to investigate
the following biomarkers in relation to adenoma recurrence: the ratio of the
degree of apoptosis to cellular proliferation, expression of the Bcl-2 family
genes (bcl-2, bak, bax) and expression of thymidylate synthase (TS) gene.
These biomarkers will be measured using immunohistochemical techniques. This
newly proposed study is feasible and extremely cost-efficient, since patients
for this study have already been recruited, follow-up information and tumor
tissue samples needed for the proposed assays have already been collected, and
laboratory methods for most biomarkers proposed in this study have already
been established in our laboratory. The questions to be investigated in this
application are important, and associations of these tumor markers with
adenoma recurrence have not been reported. This study is likely to provide
important information valuable for identifying high-risk subgroups of patients
who need close follow-up and/or intervention to reduce their risk of
If you are accessing this page during weekend or evening hours, the database may currently be offline for maintenance and should operational within a few hours. Otherwise, we have been notified of this error and will be addressing it immediately.
Please contact us
if this error persists.
We apologize for the inconvenience.
- The DCCPS Team.