||5R21CA088307-02 Interpret this number
||Fox Chase Cancer Center
||Psychological Influences on Immune Responses to HPV
DESCRIPTION: (Applicant's Description)
The role of certain types of human papillomavirus (HPV) in the etiology of
cervical cancer is well-established. However, the influence of psychosocial,
behavioral and immunologic factors on cancer risk and development needs
further exploration. The proposed project aims to elucidate the potential
links between psychological (e.g., distress, coping processes) and behavioral
(e.g., cigarette smoking) risk factors and novel immunologic measures (e.g., T
-cell proliferative responses to HPV proteins) in women with mild dysplastic
lesions of the cervix due to infection with highly oncogenic subtypes of HPV.
Specifically, the proposed project is designed to identify potential
behavioral and immunologic correlates of psychological distress and coping,
with a particular emphasis on the effects of avoidant coping strategies on
cancer risk and development. Sixty-two women referred for a follow-up
colposcopy will complete baseline psychosocial assessments and provide a blood
sample (for immune assays) prior to their colposcopy. In addition, HPV typing
of cervicovaginal cells will be conducted at baseline. Follow-up assessments
will be conducted at 6-months and 12-months post-baseline. Psychosocial
assessments include measures of psychological distress, cancer-specific
intrusive and avoidant ideation, and a variety of coping strategies. Relevant
immune measures include numbers and percentages of circulating lymphocytes, as
well as T -cell proliferative responses to synthetic peptides derived from HPV
16, a specific marker of immunocompentence and one that has been shown to be
associated with viral clearance and cervical disease regression. In addition,
medical outcome (regression, persistence, or progression of cervical lesions),
demographic variables, and behavioral risk factors (e.g., smoking) will be
assessed. The identification of potential interrelations among psychosocial,
behavioral, and immunologic variables has important implications for cancer
prevention and control, as this information can be used to guide the
development of psychological and behavioral interventions aimed at reducing
distress and avoidance, which may lead to improved behavioral, immunologic,
and health outcomes.
The effects of avoidance on cytotoxic/suppressor T cells in women with cervical lesions.
, Miller S.M.
, Mills M.
, Mangan C.E.
, Belch R.
, Campbell D.E.
, Douglas S.D.
Psycho-oncology, 2003 Sep; 12(6), p. 590-8.
Functional impairment, marital quality, and patient psychological distress as predictors of psychological distress among cancer patients' spouses.
, Manne S.L.
, Pape S.J.
Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2001 Nov; 20(6), p. 452-7.