Grant Number:	5R21CA088293-02 Interpret this number
Primary Investigator:	Lutgendorf, Susan
Organization:	University Of Iowa
Project Title:	Biobehavioral Immune Interactions in Ovarian Cancer
Fiscal Year:	2001

DESCRIPTION: (Applicant's Description) Ovarian cancer is the second most common gynecologic cancer. Because of low rates of survival for the majority of women with ovarian cancer, identification of potential factors contributing to compromised or enhanced host resistance at the earliest possible stage (pre-treatment) can increase understanding of factors that may influence disease progression and survival. The proposed project is designed to examine the relationship of stress, depression, social support, and coping in 112 women at the time of surgical diagnosis for ovarian cancer. This project is innovative in several ways. 1) We will investigate whether the behavioral-immune relationships reported in other cancers are present among women with ovarian cancers. 2) We will be using a surgery model that will allow us to examine activity of lymphocytes from peripheral blood against autologous tumor cells, as well as cytolytic activity of cells from within the tumor itself and from the ascites (fluid around the tumor). This will allow us not only to examine relationships of psychosocial variables with peripheral blood cells which likely are important in surveillance against tumor cells, but will also allow us to examine whether these relationships are present in the local environment of the tumor where inter-cell communication and cytotoxic activity is of primary importance. 3) We will be using a very sensitive and quantitative flow cytometric method to identify tumor antigen-specific CD4+ and CDS+ cells. We will look at non-specific and specific aspects of the immune response, as both are relevant to ovarian cancer. 4) We will also examine whether these behavioral-immune relationships are mediated by dysregulation in the neuroendocrine hormone cortisol. The significance of the project is that a clearer understanding of behavioral-immune mechanisms in ovarian cancer may enable the identification of biobehavioral risk factors for cancer progression that will be useful in cancer control and as targets of future intervention strategies.




Introduction to the Cancer Intervention and Surveillance Modeling Network (CISNET) Breast Cancer Models.
Authors: Alagoz O. , Berry D.A. , de Koning H.J. , Feuer E.J. , Lee S.J. , Plevritis S.K. , Schechter C.B. , Stout N.K. , Trentham-Dietz A. , Mandelblatt J.S. , et al. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2018 Apr; 38(1_suppl), p. 3S-8S.
PMID: 29554472
Related Citations

SSRI use and clinical outcomes in epithelial ovarian cancer.
Authors: Christensen D.K. , Armaiz-Pena G.N. , Ramirez E. , Matsuo K. , Zimmerman B. , Zand B. , Shinn E. , Goodheart M.J. , Bender D. , Thaker P.H. , et al. .
Source: Oncotarget, 2016-05-31 00:00:00.0; 7(22), p. 33179-91.
PMID: 27121207
Related Citations

Eudaimonic well-being and tumor norepinephrine in patients with epithelial ovarian cancer.
Authors: Davis L.Z. , Slavich G.M. , Thaker P.H. , Goodheart M.J. , Bender D.P. , Dahmoush L. , Farley D.M. , Markon K.E. , Penedo F.J. , Lubaroff D.M. , et al. .
Source: Cancer, 2015-10-01 00:00:00.0; 121(19), p. 3543-50.
EPub date: 2015-10-01 00:00:00.0.
PMID: 26096769
Related Citations

Diurnal cortisol and survival in epithelial ovarian cancer.
Authors: Schrepf A. , Thaker P.H. , Goodheart M.J. , Bender D. , Slavich G.M. , Dahmoush L. , Penedo F. , DeGeest K. , Mendez L. , Lubaroff D.M. , et al. .
Source: Psychoneuroendocrinology, 2015 Mar; 53, p. 256-67.
PMID: 25647344
Related Citations

Non-cancer life stressors contribute to impaired quality of life in ovarian cancer patients.
Authors: Lutgendorf S.K. , Slavich G.M. , Degeest K. , Goodheart M. , Bender D. , Thaker P.H. , Penedo F. , Zimmerman B. , Lucci J. , Mendez L. , et al. .
Source: Gynecologic Oncology, 2013 Dec; 131(3), p. 667-73.
PMID: 24096110
Related Citations

Sleep disturbance, distress, and quality of life in ovarian cancer patients during the first year after diagnosis.
Authors: Clevenger L. , Schrepf A. , Degeest K. , Bender D. , Goodheart M. , Ahmed A. , Dahmoush L. , Penedo F. , Lucci J. , Thaker P.H. , et al. .
Source: Cancer, 2013-09-01 00:00:00.0; 119(17), p. 3234-41.
EPub date: 2013-09-01 00:00:00.0.
PMID: 23797955
Related Citations

Sleep disturbance, cytokines, and fatigue in women with ovarian cancer.
Authors: Clevenger L. , Schrepf A. , Christensen D. , DeGeest K. , Bender D. , Ahmed A. , Goodheart M.J. , Penedo F. , Lubaroff D.M. , Sood A.K. , et al. .
Source: Brain, Behavior, And Immunity, 2012 Oct; 26(7), p. 1037-44.
PMID: 22543257
Related Citations

Social influences on clinical outcomes of patients with ovarian cancer.
Authors: Lutgendorf S.K. , De Geest K. , Bender D. , Ahmed A. , Goodheart M.J. , Dahmoush L. , Zimmerman M.B. , Penedo F.J. , Lucci J.A. , Ganjei-Azar P. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2012-08-10 00:00:00.0; 30(23), p. 2885-90.
EPub date: 2012-08-10 00:00:00.0.
PMID: 22802321
Related Citations

Biobehavioral factors and cancer progression: physiological pathways and mechanisms.
Authors: Lutgendorf S.K. , Sood A.K. .
Source: Psychosomatic Medicine, 2011 Nov-Dec; 73(9), p. 724-30.
PMID: 22021459
Related Citations

Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients.
Authors: Lutgendorf S.K. , DeGeest K. , Dahmoush L. , Farley D. , Penedo F. , Bender D. , Goodheart M. , Buekers T.E. , Mendez L. , Krueger G. , et al. .
Source: Brain, Behavior, And Immunity, 2011 Feb; 25(2), p. 250-5.
PMID: 20955777
Related Citations

Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer.
Authors: Weinrib A.Z. , Sephton S.E. , Degeest K. , Penedo F. , Bender D. , Zimmerman B. , Kirschbaum C. , Sood A.K. , Lubaroff D.M. , Lutgendorf S.K. .
Source: Cancer, 2010-09-15 00:00:00.0; 116(18), p. 4410-9.
PMID: 20564155
Related Citations

Host factors and cancer progression: biobehavioral signaling pathways and interventions.
Authors: Lutgendorf S.K. , Sood A.K. , Antoni M.H. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2010-09-10 00:00:00.0; 28(26), p. 4094-9.
EPub date: 2010-09-10 00:00:00.0.
PMID: 20644093
Related Citations

Care of the caregiver: stress and dysregulation of inflammatory control in cancer caregivers.
Authors: Lutgendorf S.K. , Laudenslager M.L. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2009-06-20 00:00:00.0; 27(18), p. 2894-5.
EPub date: 2009-06-20 00:00:00.0.
PMID: 19433678
Related Citations

Glucose as a prognostic factor in ovarian carcinoma.
Authors: Lamkin D.M. , Spitz D.R. , Shahzad M.M. , Zimmerman B. , Lenihan D.J. , Degeest K. , Lubaroff D.M. , Shinn E.H. , Sood A.K. , Lutgendorf S.K. .
Source: Cancer, 2009-03-01 00:00:00.0; 115(5), p. 1021-7.
PMID: 19156916
Related Citations

Depression, social support, and beta-adrenergic transcription control in human ovarian cancer.
Authors: Lutgendorf S.K. , DeGeest K. , Sung C.Y. , Arevalo J.M. , Penedo F. , Lucci J. , Goodheart M. , Lubaroff D. , Farley D.M. , Sood A.K. , et al. .
Source: Brain, Behavior, And Immunity, 2009 Feb; 23(2), p. 176-83.
PMID: 18550328
Related Citations

Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma.
Authors: Lutgendorf S.K. , Lamkin D.M. , Jennings N.B. , Arevalo J.M. , Penedo F. , DeGeest K. , Langley R.R. , Lucci J.A. , Cole S.W. , Lubaroff D.M. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2008-11-01 00:00:00.0; 14(21), p. 6839-46.
PMID: 18980978
Related Citations

Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients.
Authors: Lutgendorf S.K. , Weinrib A.Z. , Penedo F. , Russell D. , DeGeest K. , Costanzo E.S. , Henderson P.J. , Sephton S.E. , Rohleder N. , Lucci J.A. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2008-10-10 00:00:00.0; 26(29), p. 4820-7.
EPub date: 2008-10-10 00:00:00.0.
PMID: 18779606
Related Citations

Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients.
Authors: Lutgendorf S.K. , Lamkin D.M. , DeGeest K. , Anderson B. , Dao M. , McGinn S. , Zimmerman B. , Maiseri H. , Sood A.K. , Lubaroff D.M. .
Source: Brain, Behavior, And Immunity, 2008 Aug; 22(6), p. 890-900.
PMID: 18276105
Related Citations

Positive psychosocial factors and NKT cells in ovarian cancer patients.
Authors: Lamkin D.M. , Lutgendorf S.K. , McGinn S. , Dao M. , Maiseri H. , DeGeest K. , Sood A.K. , Lubaroff D.M. .
Source: Brain, Behavior, And Immunity, 2008 Jan; 22(1), p. 65-73.
PMID: 17643954
Related Citations

Quality of life and mental health in cervical and endometrial cancer survivors.
Authors: Bradley S. , Rose S. , Lutgendorf S. , Costanzo E. , Anderson B. .
Source: Gynecologic Oncology, 2006 Mar; 100(3), p. 479-86.
PMID: 16185753
Related Citations

The SPECTRUM population model of the impact of screening and treatment on U.S. breast cancer trends from 1975 to 2000: principles and practice of the model methods.
Authors: Mandelblatt J. , Schechter C.B. , Lawrence W. , Yi B. , Cullen J. .
Source: Journal Of The National Cancer Institute. Monographs, 2006; (36), p. 47-55.
PMID: 17032894
Related Citations

Social support, psychological distress, and natural killer cell activity in ovarian cancer.
Authors: Lutgendorf S.K. , Sood A.K. , Anderson B. , McGinn S. , Maiseri H. , Dao M. , Sorosky J.I. , De Geest K. , Ritchie J. , Lubaroff D.M. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2005-10-01 00:00:00.0; 23(28), p. 7105-13.
PMID: 16192594
Related Citations

Psychosocial factors and interleukin-6 among women with advanced ovarian cancer.
Authors: Costanzo E.S. , Lutgendorf S.K. , Sood A.K. , Anderson B. , Sorosky J. , Lubaroff D.M. .
Source: Cancer, 2005-07-15 00:00:00.0; 104(2), p. 305-13.
PMID: 15954082
Related Citations

Toward optimal screening strategies for older women. Costs, benefits, and harms of breast cancer screening by age, biology, and health status.
Authors: Mandelblatt J.S. , Schechter C.B. , Yabroff K.R. , Lawrence W. , Dignam J. , Extermann M. , Fox S. , Orosz G. , Silliman R. , Cullen J. , et al. .
Source: Journal Of General Internal Medicine, 2005 Jun; 20(6), p. 487-96.
PMID: 15987322
Related Citations

Distress and expression of natural killer receptors on lymphocytes.
Authors: Lutgendorf S.K. , Moore M.B. , Bradley S. , Shelton B.J. , Lutz C.T. .
Source: Brain, Behavior, And Immunity, 2005 May; 19(3), p. 185-94.
PMID: 15797305
Related Citations

Mood and cytokine response to influenza virus in older adults.
Authors: Costanzo E.S. , Lutgendorf S.K. , Kohut M.L. , Nisly N. , Rozeboom K. , Spooner S. , Benda J. , McElhaney J.E. .
Source: The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences, 2004 Dec; 59(12), p. 1328-33.
PMID: 15699534
Related Citations

Religious participation, interleukin-6, and mortality in older adults.
Authors: Lutgendorf S.K. , Russell D. , Ullrich P. , Harris T.B. , Wallace R. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2004 Sep; 23(5), p. 465-75.
PMID: 15367066
Related Citations

Benefits and costs of interventions to improve breast cancer outcomes in African American women.
Authors: Mandelblatt J.S. , Schechter C.B. , Yabroff K.R. , Lawrence W. , Dignam J. , Muennig P. , Chavez Y. , Cullen J. , Fahs M. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2004-07-01 00:00:00.0; 22(13), p. 2554-66.
EPub date: 2004-07-01 00:00:00.0.
PMID: 15173213
Related Citations

Short-term impact of cancer prevention and screening activities on quality of life.
Authors: Cullen J. , Schwartz M.D. , Lawrence W.F. , Selby J.V. , Mandelblatt J.S. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2004-03-01 00:00:00.0; 22(5), p. 943-52.
PMID: 14990651
Related Citations

Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines.
Authors: Lutgendorf S.K. , Cole S. , Costanzo E. , Bradley S. , Coffin J. , Jabbari S. , Rainwater K. , Ritchie J.M. , Yang M. , Sood A.K. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2003-10-01 00:00:00.0; 9(12), p. 4514-21.
PMID: 14555525
Related Citations

Psychoneuroimmunology and health psychology: an integrative model.
Authors: Lutgendorf S.K. , Costanzo E.S. .
Source: Brain, Behavior, And Immunity, 2003 Aug; 17(4), p. 225-32.
PMID: 12831823
Related Citations

Vascular endothelial growth factor and social support in patients with ovarian carcinoma.
Authors: Lutgendorf S.K. , Johnsen E.L. , Cooper B. , Anderson B. , Sorosky J.I. , Buller R.E. , Sood A.K. .
Source: Cancer, 2002-08-15 00:00:00.0; 95(4), p. 808-15.
PMID: 12209725
Related Citations