Grant Details
Grant Number: |
5R21CA088272-02 Interpret this number |
Primary Investigator: |
Al'Absi, Mustafa |
Organization: |
University Of Minnesota Duluth |
Project Title: |
Psychobiological Mechanisms of Smoking Relapse |
Fiscal Year: |
2001 |
Abstract
DESCRIPTION: (Applicant's Description)
Cigarette smoking is the leading preventable cause of cancer and
cardiovascular diseases. Although the decades have witnessed accelerated
efforts to develop effective smoking cessation strategies, the long-term
success rates have been disappointing. The majority of smokers relapse within
two weeks of a cessation attempt, and little is known about the nature of this
early relapse. Smoking cessation is associated with negative affect symptoms.
These symptoms are intensified in stressful situations, possibly accelerating
the progression towards a full relapse. Mechanisms responsible for this stress
effect are not known. Without specific knowledge of the stress-related
biobehavioral changes, targeted efforts to reduce smoking and relapse will
remain limited. The long-term goal of this research is to determine the
psycho biological mechanisms responsible for smoking relapse. The specific
goal of this project is to evaluate hormonal changes during early abstinence
and in response to behavioral stress, and to assess the extent to which these
changes predict early relapse. Our central hypothesis is that exaggerated
responses to behavioral stress predict a shorter time to relapse. This
hypothesis is based on the well-established observation that stressful events,
characterized by negative emotions, are associated with rises in
adrenocorticotropic hormone (ACTH) and cortisol concentrations. It is also
based on the observation that environmental stressors increase the risk for
smoking relapse. We will specifically determine the extent to which basal
cortisol activity during early smoking abstinence predicts relapse, examine
endocrine and cardiovascular responses to stress as predictors of smoking
relapse, and evaluate gender differences in psycho biological changes during
smoking abstinence and in response to behavioral stress.
This research focuses on the pituitary-adrenocortical axis, an important
stress-related biological system recently implicated in addiction. We will
integrate hormonal, autonomic and psychological indices to gain an accurate
profile of the stress response patterning among smokers and use this
information in a prospective fashion to predict relapse in men and women. The
results will provide a base of knowledge concerning psycho biological changes
associated with quitting and risk for relapse. This information will
facilitate efforts towards improving methods to identify and assist
individuals at high risk for relapse. Reducing relapse rates will contribute
significantly towards reducing smoking and its harmful effects.
Publications
Patterns of change in affect and adrenocortical activity over an extended period of smoking abstinence.
Authors: Nakajima M.
, al'Absi M.
.
Source: Psychology Of Addictive Behaviors : Journal Of The Society Of Psychologists In Addictive Behaviors, 2013 Dec; 27(4), p. 1189-95.
PMID: 24128290
Related Citations
Predictors of risk for smoking relapse in men and women: a prospective examination.
Authors: Nakajima M.
, al'Absi M.
.
Source: Psychology Of Addictive Behaviors : Journal Of The Society Of Psychologists In Addictive Behaviors, 2012 Sep; 26(3), p. 633-7.
PMID: 22352701
Related Citations
Enhanced pain perception prior to smoking cessation is associated with early relapse.
Authors: Nakajima M.
, al'Absi M.
.
Source: Biological Psychology, 2011 Sep; 88(1), p. 141-6.
PMID: 21816208
Related Citations
Effect of stress and bupropion on craving, withdrawal symptoms, and mood in smokers.
Authors: Kotlyar M.
, Drone D.
, Thuras P.
, Hatsukami D.K.
, Brauer L.
, Adson D.E.
, al'Absi M.
.
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2011 Jun; 13(6), p. 492-7.
PMID: 21378081
Related Citations
Circulating leptin levels are associated with increased craving to smoke in abstinent smokers.
Authors: al'Absi M.
, Hooker S.
, Fujiwara K.
, Kiefer F.
, von der Goltz C.
, Cragin T.
, Wittmers L.E.
.
Source: Pharmacology, Biochemistry, And Behavior, 2011 Jan; 97(3), p. 509-13.
PMID: 20951159
Related Citations
Blunted opiate modulation of prolactin response in smoking men and women.
Authors: Shaw D.
, al'Absi M.
.
Source: Pharmacology, Biochemistry, And Behavior, 2010 Mar; 95(1), p. 1-5.
PMID: 19969014
Related Citations
Sex-specific associations of body mass index with mood disturbance during smoking abstinence.
Authors: Ceballos N.A.
, Hooker S.
, al'Absi M.
.
Source: Neuropsychobiology, 2009; 60(1), p. 37-43.
PMID: 19729971
Related Citations
Blunted opiate modulation of hypothalamic-pituitary-adrenocortical activity in men and women who smoke.
Authors: al'Absi M.
, Wittmers L.E.
, Hatsukami D.
, Westra R.
.
Source: Psychosomatic Medicine, 2008 Oct; 70(8), p. 928-35.
PMID: 18799426
Related Citations
Attenuated beta endorphin response to acute stress is associated with smoking relapse.
Authors: Shaw D.
, al'Absi M.
.
Source: Pharmacology, Biochemistry, And Behavior, 2008 Sep; 90(3), p. 357-62.
PMID: 18495227
Related Citations
Naltrexone effect on physiological and subjective response to a cold pressor task.
Authors: Kotlyar M.
, al'Absi M.
, Brauer L.H.
, Grant J.E.
, Fong E.
, Kim S.W.
.
Source: Biological Psychology, 2008 Feb; 77(2), p. 233-6.
PMID: 18053632
Related Citations
Anger and psychobiological changes during smoking abstinence and in response to acute stress: prediction of smoking relapse.
Authors: al'Absi M.
, Carr S.B.
, Bongard S.
.
Source: International Journal Of Psychophysiology : Official Journal Of The International Organization Of Psychophysiology, 2007 Nov; 66(2), p. 109-15.
PMID: 17544533
Related Citations
Anger management style and endogenous opioid function: is gender a moderator?
Authors: Bruehl S.
, al'Absi M.
, France C.R.
, France J.
, Harju A.
, Burns J.W.
, Chung O.Y.
.
Source: Journal Of Behavioral Medicine, 2007 Jun; 30(3), p. 209-19.
PMID: 17410417
Related Citations
Are smokers' reasons for smoking related to their body mass indices?
Authors: Hovland J.
, Ceballos N.A.
.
Source: Substance Use & Misuse, 2007; 42(8), p. 1337-44.
PMID: 17674237
Related Citations
Dehydroepiandrosterone sulfate, cortisol, mood state and smoking cessation: relationship to relapse status at 4-week follow-up.
Authors: Ceballos N.A.
, al'Absi M.
.
Source: Pharmacology, Biochemistry, And Behavior, 2006 Sep; 85(1), p. 23-8.
PMID: 16908055
Related Citations
Hypothalamic-pituitary-adrenocortical responses to psychological stress and risk for smoking relapse.
Authors: al'Absi M.
.
Source: International Journal Of Psychophysiology : Official Journal Of The International Organization Of Psychophysiology, 2006 Mar; 59(3), p. 218-27.
PMID: 16442170
Related Citations
Adrenocortical and nociceptive responses to opioid blockade in hypertension-prone men and women.
Authors: al'Absi M.
, France C.
, Harju A.
, France J.
, Wittmers L.
.
Source: Psychosomatic Medicine, 2006 Mar-Apr; 68(2), p. 292-8.
PMID: 16554396
Related Citations
Blood pressure stress reactivity and left ventricular mass in a random community sample of African-American and caucasian men and women.
Authors: al'Absi M.
, Devereux R.B.
, Rao D.C.
, Kitzman D.
, Oberman A.
, Hopkins P.
, Arnett D.K.
.
Source: The American Journal Of Cardiology, 2006-01-15 00:00:00.0; 97(2), p. 240-4.
PMID: 16442370
Related Citations
Attenuated adrenocorticotropic responses to psychological stress are associated with early smoking relapse.
Authors: al'Absi M.
, Hatsukami D.
, Davis G.L.
.
Source: Psychopharmacology, 2005 Aug; 181(1), p. 107-17.
PMID: 15834539
Related Citations
How accurate are parental chronic pain histories provided by offspring?
Authors: Bruehl S.
, France C.R.
, France J.
, Harju A.
, al'Absi M.
.
Source: Pain, 2005 Jun; 115(3), p. 390-7.
PMID: 15911166
Related Citations
Salivary cortisol concentrations are associated with acute nicotine withdrawal.
Authors: Cohen L.M.
, al'Absi M.
, Collins F.L.
.
Source: Addictive Behaviors, 2004 Nov; 29(8), p. 1673-8.
PMID: 15451136
Related Citations
Prospective examination of effects of smoking abstinence on cortisol and withdrawal symptoms as predictors of early smoking relapse.
Authors: al'Absi M.
, Hatsukami D.
, Davis G.L.
, Wittmers L.E.
.
Source: Drug And Alcohol Dependence, 2004-03-08 00:00:00.0; 73(3), p. 267-78.
PMID: 15036549
Related Citations
Sex differences in pain and hypothalamic-pituitary-adrenocortical responses to opioid blockade.
Authors: al'Absi M.
, Wittmers L.E.
, Ellestad D.
, Nordehn G.
, Kim S.W.
, Kirschbaum C.
, Grant J.E.
.
Source: Psychosomatic Medicine, 2004 Mar-Apr; 66(2), p. 198-206.
PMID: 15039504
Related Citations
Enhanced adrenocortical responses to stress in hypertension-prone men and women.
Authors: al'Absi M.
, Wittmers L.E.
.
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2003 Winter; 25(1), p. 25-33.
PMID: 12581933
Related Citations
Blood pressure but not cortisol mediates stress effects on subsequent pain perception in healthy men and women.
Authors: al'Absi M.
, Petersen K.L.
.
Source: Pain, 2003 Dec; 106(3), p. 285-95.
PMID: 14659511
Related Citations
Attenuated adrenocortical and blood pressure responses to psychological stress in ad libitum and abstinent smokers.
Authors: al'Absi M.
, Wittmers L.E.
, Erickson J.
, Hatsukami D.
, Crouse B.
.
Source: Pharmacology, Biochemistry, And Behavior, 2003 Jan; 74(2), p. 401-10.
PMID: 12479961
Related Citations
Psychophysiological effects of nicotine abstinence and behavioral challenges in habitual smokers.
Authors: al'Absi M.
, Amunrud T.
, Wittmers L.E.
.
Source: Pharmacology, Biochemistry, And Behavior, 2002 Jun; 72(3), p. 707-16.
PMID: 12175468
Related Citations
Adrenocortical and hemodynamic predictors of pain perception in men and women.
Authors: al'Absi M.
, Petersen K.L.
, Wittmers L.E.
.
Source: Pain, 2002 Mar; 96(1-2), p. 197-204.
PMID: 11932075
Related Citations