Grant Number:	5R01CA085566-02 Interpret this number
Primary Investigator:	Manne, Sharon
Organization:	Fox Chase Cancer Center
Project Title:	Psychological Intervention for Ovarian Cancer Patients
Fiscal Year:	2001

Women who are diagnosed with ovarian cancer typically undergo an aggressive surgical and chemotherapy region which has an uncertain outcome. Mortality rates for this disease are high, as the chemotherapy regimen which has an uncertain outcome. Mortality rates for this disease are high, as are the rates for recurrence. Women undergoing treatment for this disease are subject to a large number of stresses. Despite the significant threat to life and bodily integrity these patients may endure, relatively few empirical studies have determined whether psychological interventions an improve ovarian cancer patients' emotional and social functioning. The goal of this research is to test two psychological interventions designed to bolster quality of life during and after treatment for ovarian cancer. The proposed study is a controlled clinical trial with three experimental conditions: non-directive supportive therapy, coping and communication skills therapy, and a standard care control group. Three hundred fifty eight women, recently diagnosed with Stage I to III ovarian cancer, will be randomly assigned to either a seven session coping and communication skill intervention, a seven session non-directive supportive therapy condition, or standard psychosocial care. The coping and communication skills intervention will assist patients in using adaptive cognitive processing/coping (emotional approach, positive reappraisal and growth, finding meaning) and learning communication skills to obtain more support from others. The non-directive supportive therapy intervention will focus on allowing the patient to ventilate and work through emotions she is experiencing. The intervention methods are based on cognitive processing theories of traumatic events and our prior work. We predict that both interventions will result in less distress in the short-term, the oping and communication skills intervention will result in more benefit in the long-term, because the patients are taught skills to enhance their cognitive and social processing of cancer within their existing social network. Patients will be assessed using questionnaire methods pre- and post-intervention, and at 9-month post-intervention follow-up.




Relationship intimacy processes during treatment for couple-focused interventions for prostate cancer patients and their spouses.
Authors: Manne S.L. , Kashy D.A. , Kissane D. , Zaider T. , Heckman C.J. , Penedo F.J. , Myers S. .
Source: Journal Of Psychosocial Oncology Research And Practice, 2019 Sep; 1(2), .
EPub date: 2019-09-20 00:00:00.0.
PMID: 36237825
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Longitudinal course and predictors of communication and affect management self-efficacy among women newly diagnosed with gynecological cancers.
Authors: Manne S.L. , Kashy D.A. , Kissane D.W. , Ozga M. , Virtue S.M. , Heckman C.J. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2019-08-01 00:00:00.0; , .
EPub date: 2019-08-01 00:00:00.0.
PMID: 31367918
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The course and predictors of perceived unsupportive responses by family and friends among women newly diagnosed with gynecological cancers.
Authors: Manne S.L. , Kashy D.A. , Kissane D.W. , Ozga M. , Virtue S.M. , Heckman C.J. .
Source: Translational Behavioral Medicine, 2019-07-16 00:00:00.0; 9(4), p. 682-692.
PMID: 30189025
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Levels of emotional awareness during psychotherapy among gynecologic cancer patients.
Authors: Virtue S.M. , Manne S.L. , Criswell K. , Kissane D. , Heckman C.J. , Rotter D. .
Source: Palliative & Supportive Care, 2019 02; 17(1), p. 87-94.
EPub date: 2018-06-08 00:00:00.0.
PMID: 29880065
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Acceptance, social support, benefit-finding, and depression in women with gynecological cancer.
Authors: Manne S.L. , Kashy D.A. , Virtue S. , Criswell K.R. , Kissane D.W. , Ozga M. , Heckman C.J. , Stapleton J. , Rodriguez L. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2018-08-20 00:00:00.0; , .
EPub date: 2018-08-20 00:00:00.0.
PMID: 30128785
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Emotional processing during psychotherapy among women newly diagnosed with a gynecological cancer.
Authors: Manne S.L. , Myers-Virtue S. , Darabos K. , Ozga M. , Heckman C. , Kissane D. , Rotter D. .
Source: Palliative & Supportive Care, 2017 08; 15(4), p. 405-416.
EPub date: 2016-12-14 00:00:00.0.
PMID: 27964770
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A Comparison Of Two Psychological Interventions For Newly-diagnosed Gynecological Cancer Patients
Authors: Manne S.L. , Virtue S.M. , Ozga M. , Kashy D. , Heckman C. , Kissane D. , Rosenblum N. , Morgan M. , Rodriquez L. .
Source: Gynecologic Oncology, 2016-11-22 00:00:00.0; , .
PMID: 27887806
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Therapy processes, progress, and outcomes for 2 therapies for gynecological cancer patients.
Authors: Manne S.L. , Myers-Virtue S. , Kashy D.A. , Ozga M. , Kissane D. , Heckman C. , Morgan M. .
Source: Psycho-oncology, 2016-11-21 00:00:00.0; , .
EPub date: 2016-11-21 00:00:00.0.
PMID: 27870116
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Quality Of Life Trajectories After Diagnosis Of Gynecologic Cancer: A Theoretically Based Approach
Authors: Gonzalez B.D. , Manne S.L. , Stapleton J. , Myers-Virtue S. , Ozga M. , Kissane D. , Heckman C. , Morgan M. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2016-10-19 00:00:00.0; , .
PMID: 27757706
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Group-based Trajectory Modeling Of Fear Of Disease Recurrence Among Women Recently Diagnosed With Gynecological Cancers
Authors: Manne S.L. , Myers-Virtue S. , Kissane D. , Ozga M.L. , Kashy D.A. , Rubin S.C. , Rosenblum N.G. , Heckman C.J. .
Source: Psycho-oncology, 2016-07-16 00:00:00.0; , .
PMID: 27421919
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Emotion episodes during psychotherapy sessions among women newly diagnosed with gynecological cancers.
Authors: Myers Virtue S. , Manne S.L. , Darabos K. , Heckman C.J. , Ozga M. , Kissane D. , Rubin S. , Rosenblum N. .
Source: Psycho-oncology, 2015 Sep; 24(9), p. 1189-96.
PMID: 25521772
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Resilience, Positive Coping, and Quality of Life Among Women Newly Diagnosed With Gynecological Cancers.
Authors: Manne S.L. , Myers-Virtue S. , Kashy D. , Ozga M. , Kissane D. , Heckman C. , Rubin S.C. , Rosenblum N. .
Source: Cancer Nursing, 2015 Sep-Oct; 38(5), p. 375-82.
PMID: 25521911
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Holding back sharing concerns, dispositional emotional expressivity, perceived unsupportive responses and distress among women newly diagnosed with gynecological cancers.
Authors: Manne S. , Myers S. , Ozga M. , Kissane D. , Kashy D. , Rubin S. , Heckman C. , Rosenblum N. .
Source: General Hospital Psychiatry, 2014 Jan-Feb; 36(1), p. 81-7.
PMID: 24211156
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Cancer-related concerns among women with a new diagnosis of gynecological cancer: an exploration of age group differences.
Authors: Myers Virtue S. , Manne S.L. , Ozga M. , Kissane D.W. , Rubin S. , Heckman C. , Rosenblum N. , Graff J.J. .
Source: International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society, 2014 Jan; 24(1), p. 165-71.
PMID: 24346489
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Social-cognitive processes associated with fear of recurrence among women newly diagnosed with gynecological cancers.
Authors: Myers S.B. , Manne S.L. , Kissane D.W. , Ozga M. , Kashy D.A. , Rubin S. , Heckman C. , Rosenblum N. , Morgan M. , Graff J.J. .
Source: Gynecologic Oncology, 2013 Jan; 128(1), p. 120-7.
PMID: 23088925
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Therapist and patient perceptions of alliance and progress in psychological therapy for women diagnosed with gynecological cancers.
Authors: Manne S.L. , Kashy D.A. , Rubin S. , Hernandez E. , Bergman C. .
Source: Journal Of Consulting And Clinical Psychology, 2012 Oct; 80(5), p. 800-10.
PMID: 22746145
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Therapy processes and outcomes of psychological interventions for women diagnosed with gynecological cancers: A test of the generic process model of psychotherapy.
Authors: Manne S. , Winkel G. , Zaider T. , Rubin S. , Hernandez E. , Bergman C. .
Source: Journal Of Consulting And Clinical Psychology, 2010 Apr; 78(2), p. 236-48.
PMID: 20350034
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Mediators of a coping and communication-enhancing intervention and a supportive counseling intervention among women diagnosed with gynecological cancers.
Authors: Manne S.L. , Winkel G. , Rubin S. , Edelson M. , Rosenblum N. , Bergman C. , Hernandez E. , Carlson J. , Rocereto T. .
Source: Journal Of Consulting And Clinical Psychology, 2008 Dec; 76(6), p. 1034-45.
PMID: 19045971
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Ovarian cancer patients' psychological distress: the role of physical impairment, perceived unsupportive family and friend behaviors, perceived control, and self-esteem.
Authors: Norton T.R. , Manne S.L. , Rubin S. , Hernandez E. , Carlson J. , Bergman C. , Rosenblum N. .
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2005 Mar; 24(2), p. 143-52.
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Prevalence and predictors of psychological distress among women with ovarian cancer.
Authors: Norton T.R. , Manne S.L. , Rubin S. , Carlson J. , Hernandez E. , Edelson M.I. , Rosenblum N. , Warshal D. , Bergman C. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2004-03-01 00:00:00.0; 22(5), p. 919-26.
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