Grant Number:	5R01CA078990-04 Interpret this number
Primary Investigator:	Syrjala, Karen
Organization:	Fred Hutchinson Cancer Research Center
Project Title:	Enhancing Long Term Survival After Bmt
Fiscal Year:	2001

DESCRIPTION: (Applicant's Description) This application proposes to evaluate factors requiring intervention to enhance long-term survival in adults after blood or marrow transplantation (BMT). In previous work, we have followed patients prospectively from pre-transplant with psychophysical, neuropsychologic, and endocrinologic assessments. With this application, we would continue outcome evaluation of two cohorts of survivors. We have followed the first cohort to five years and will complete a ten-year follow-up to evaluate late effects (n = 108 five year survivors plus a matched comparison sample). The second cohort of survivors participated in a randomized controlled clinical trial to enhance recovery from BMT. This cohort will complete follow-up to five years, with testing that includes neuropsychologic and endocrinologic evaluation (n = 100 five year survivors plus a matched comparison sample) to determine long-term survivor issues and efficacy of the clinical trial. A small subset of the second cohort would participate in a pilot study of interventions to reduce long-term impacts in at-risk survivors. Specific aims are to: 1) evaluate the functional capabilities of adult BMT recipients in work, stamina, cognition, family adaptations, emotional fluctuations, infertility, and, for women, menopausal symptoms and sexual function; 2) evaluate the interaction of medical and psychophysical late effects in ten-year survivors as compared with their own status at five years and pre-transplant; 3) identify areas that have an impact on long-term survivors to a greater extent than matched healthy comparison samples; 4) define predictors of physiologic and psychologic morbidity in long-term survivors; 5) examine, prospectively, long-term neuropsychological and hormonal changes and their impacts; 6) evaluate the long-term outcome of a randomized controlled clinical trial to enhance recovery; and 7) design and pilot interventions to target at-risk long-term survivors as defined by this research. Hypotheses are defined in the application. This study is an interdisciplinary research effort which considers medical, psychological, social, functional, hormonal, and neuropsychological interactions in addressing the problems and needs of long-term survivors. The BMT setting provides a well standardized environment in which to examine these aims, all of which are applicable both to the ever-increasing numbers of transplantation survivors and to other populations of cancer survivors.




Psychometric properties of the Cancer and Treatment Distress (CTXD) measure in hematopoietic cell transplantation patients.
Authors: Syrjala K.L. , Yi J.C. , Langer S.L. .
Source: Psycho-oncology, 2016 May; 25(5), p. 529-35.
PMID: 26130497
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The effect of pre-transplant distress on immune reconstitution among adult autologous hematopoietic cell transplantation patients.
Authors: McGregor B.A. , Syrjala K.L. , Dolan E.D. , Langer S.L. , Redman M. .
Source: Brain, Behavior, And Immunity, 2013 Mar; 30 Suppl, p. S142-8.
PMID: 22910186
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A Brief Symptom Index For Advanced Lung Cancer
Authors: Yount,S. , Beaumont,J. , Rosenbloom,S. , Cella,D. , Patel,J. , Hensing,T. , Jacobsen,P.B. , Syrjala,K. , Abernethy,A.P. .
Source: Clinical Lung Cancer, 2012 Jan; 13(1), p. 14-23.
PMID: 21729652
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Prospective Neurocognitive Function Over 5 Years After Allogeneic Hematopoietic Cell Transplantation For Cancer Survivors Compared With Matched Controls At 5 Years
Authors: Syrjala K.L. , Artherholt S.B. , Kurland B.F. , Langer S.L. , Roth-Roemer S. , Elrod J.B. , Dikmen S. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2011-06-10 00:00:00.0; 29(17), p. 2397-404.
PMID: 21537032
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Pre- And Post-transplantation Risk Factors For Delirium Onset And Severity In Patients Undergoing Hematopoietic Stem-cell Transplantation
Authors: Fann J.R. , Hubbard R.A. , Alfano C.M. , Roth-Roemer S. , Katon W.J. , Syrjala K.L. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2011-03-01 00:00:00.0; 29(7), p. 895-901.
PMID: 21263081
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Impact Of Delirium On Decision-making Capacity After Hematopoietic Stem-cell Transplantation
Authors: Zaubler T. , Fann J.R. , Roth-Roemer S. , Katon W.J. , Bustami R. , Syrjala K.L. .
Source: Psychosomatics, 2010 Jul-Aug; 51(4), p. 320-9.
PMID: 20587760
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Impact Of Delirium On Distress, Health-related Quality Of Life, And Cognition 6 Months And 1 Year After Hematopoietic Cell Transplant
Authors: Basinski J.R. , Alfano C.M. , Katon W.J. , Syrjala K.L. , Fann J.R. .
Source: Biology Of Blood And Marrow Transplantation : Journal Of The American Society For Blood And Marrow Transplantation, 2010 Jun; 16(6), p. 824-31.
PMID: 20100587
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The Quality Of Life Of Adult Survivors Of Childhood Hematopoietic Cell Transplant
Authors: Sanders,J.E. , Hoffmeister,P.A. , Storer,B.E. , Appelbaum,F.R. , Storb,R.F. , Syrjala,K.L. .
Source: Bone Marrow Transplantation, 2010 Apr; 45(4), p. 746-54.
PMID: 19718073
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Prospective Predictors Of Return To Work In The 5 Years After Hematopoietic Cell Transplantation
Authors: Kirchhoff A.C. , Leisenring W. , Syrjala K.L. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2010 Mar; 4(1), p. 33-44.
PMID: 19936935
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Marital adjustment, satisfaction and dissolution among hematopoietic stem cell transplant patients and spouses: a prospective, five-year longitudinal investigation.
Authors: Langer S.L. , Yi J.C. , Storer B.E. , Syrjala K.L. .
Source: Psycho-oncology, 2010 Feb; 19(2), p. 190-200.
PMID: 19189319
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Intrapersonal and interpersonal consequences of protective buffering among cancer patients and caregivers.
Authors: Langer S.L. , Brown J.D. , Syrjala K.L. .
Source: Cancer, 2009-09-15 00:00:00.0; 115(18 Suppl), p. 4311-25.
PMID: 19731352
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Sexuality After Hematopoietic Stem Cell Transplantation
Authors: Yi J.C. , Syrjala K.L. .
Source: Cancer Journal (sudbury, Mass.), 2009 Jan-Feb; 15(1), p. 57-64.
PMID: 19197175
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Physical and psychological long-term and late effects of cancer.
Authors: Stein K.D. , Syrjala K.L. , Andrykowski M.A. .
Source: Cancer, 2008-06-01 00:00:00.0; 112(11 Suppl), p. 2577-92.
PMID: 18428205
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Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy.
Authors: Butt Z. , Rosenbloom S.K. , Abernethy A.P. , Beaumont J.L. , Paul D. , Hampton D. , Jacobsen P.B. , Syrjala K.L. , Von Roenn J.H. , Cella D. .
Source: Journal Of The National Comprehensive Cancer Network : Jnccn, 2008 May; 6(5), p. 448-55.
PMID: 18492460
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Patient Training In Cancer Pain Management Using Integrated Print And Video Materials: A Multisite Randomized Controlled Trial
Authors: Syrjala K.L. , Abrams J.R. , Polissar N.L. , Hansberry J. , Robison J. , DuPen S. , Stillman M. , Fredrickson M. , Rivkin S. , Feldman E. , et al. .
Source: Pain, 2008 Mar; 135(1-2), p. 175-86.
PMID: 18093738
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Sexual Function Changes During The 5 Years After High-dose Treatment And Hematopoietic Cell Transplantation For Malignancy, With Case-matched Controls At 5 Years
Authors: Syrjala K.L. , Kurland B.F. , Abrams J.R. , Sanders J.E. , Heiman J.R. .
Source: Blood, 2008-02-01 00:00:00.0; 111(3), p. 989-96.
PMID: 17878404
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Fertility And Risk Factors For Elevated Infertility Concern In 10-year Hematopoietic Cell Transplant Survivors And Case-matched Controls
Authors: Hammond C. , Abrams J.R. , Syrjala K.L. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2007-08-10 00:00:00.0; 25(23), p. 3511-7.
PMID: 17646668
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Impact Of Delirium On Cognition, Distress, And Health-related Quality Of Life After Hematopoietic Stem-cell Transplantation
Authors: Fann J.R. , Alfano C.M. , Roth-Roemer S. , Katon W.J. , Syrjala K.L. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2007-04-01 00:00:00.0; 25(10), p. 1223-31.
PMID: 17401011
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Late Effects Of Hematopoietic Cell Transplantation Among 10-year Adult Survivors Compared With Case-matched Controls
Authors: Syrjala K.L. , Langer S.L. , Abrams J.R. , Storer B.E. , Martin P.J. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2005-09-20 00:00:00.0; 23(27), p. 6596-606.
PMID: 16170167
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Clinical Presentation Of Delirium In Patients Undergoing Hematopoietic Stem Cell Transplantation
Authors: Fann J.R. , Alfano C.M. , Burington B.E. , Roth-Roemer S. , Katon W.J. , Syrjala K.L. .
Source: Cancer, 2005-02-15 00:00:00.0; 103(4), p. 810-20.
PMID: 15643598
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Neuropsychologic changes from before transplantation to 1 year in patients receiving myeloablative allogeneic hematopoietic cell transplant.
Authors: Syrjala K.L. , Dikmen S. , Langer S.L. , Roth-Roemer S. , Abrams J.R. .
Source: Blood, 2004-11-15 00:00:00.0; 104(10), p. 3386-92.
EPub date: 2004-11-15 00:00:00.0.
PMID: 15251983
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Physicians' Attitudes About Quality-of-life Issues In Hematopoietic Stem Cell Transplantation
Authors: Lee S.J. , Joffe S. , Kim H.T. , Socie G. , Gilman A.L. , Wingard J.R. , Horowitz M.M. , Cella D. , Syrjala K.L. .
Source: Blood, 2004-10-01 00:00:00.0; 104(7), p. 2194-200.
PMID: 15198954
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Recovery And Long-term Function After Hematopoietic Cell Transplantation For Leukemia Or Lymphoma
Authors: Syrjala K.L. , Langer S.L. , Abrams J.R. , Storer B. , Sanders J.E. , Flowers M.E. , Martin P.J. .
Source: Jama, 2004-05-19 00:00:00.0; 291(19), p. 2335-43.
PMID: 15150205
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The Neuropsychology Of Cancer Treatment. Introduction
Authors: Syrjala K.L. .
Source: Seminars In Clinical Neuropsychiatry, 2003 Oct; 8(4), p. 197-200.
PMID: 14613047
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Mood disturbance in the cancer setting: effects of gender and patient/spouse role.
Authors: Langer S.L. .
Source: Seminars In Clinical Neuropsychiatry, 2003 Oct; 8(4), p. 276-85.
PMID: 14613053
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Caregiver And Patient Marital Satisfaction And Affect Following Hematopoietic Stem Cell Transplantation: A Prospective, Longitudinal Investigation
Authors: Langer S. , Abrams J. , Syrjala K. .
Source: Psycho-oncology, 2003 Apr-May; 12(3), p. 239-53.
PMID: 12673808
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Delirium In Patients Undergoing Hematopoietic Stem Cell Transplantation
Authors: Fann J.R. , Roth-Roemer S. , Burington B.E. , Katon W.J. , Syrjala K.L. .
Source: Cancer, 2002-11-01 00:00:00.0; 95(9), p. 1971-81.
PMID: 12404292
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