Grant Details
Grant Number: |
5U24CA078142-04 Interpret this number |
Primary Investigator: |
Strong, Louise |
Organization: |
University Of Texas Md Anderson Can Ctr |
Project Title: |
Texas Cancer Genetics Consortium |
Fiscal Year: |
2001 |
Abstract
DESCRIPTION: (Applicant's Description) We propose a Texas Cancer Genetics
Consortium (TCGC) in response to the Cancer Genetics Network (CGN) RFA
CA-97-004. This TCGC would bring to the CGN extensive expertise in basic
and clinical cancer genetics, human and molecular genetics, management of
confidential human cancer genetics data, community outreach in human
genetics, professional and public education, and psychosocial studies of the
impact of cancer genetic counseling and testing. The TCGC will include
existing cancer high risk clinical populations, Ashkenazi Jewish
populations, registries of familial breast, colon, MEN2, NF1 and other
genetic susceptibility syndromes, many followed in studies for decades,
patients at high cancer risk participating in screening and early detection
studies or chemoprevention trials, and a large database of cancer patients
from which to identify high risk family members for potential recruitment to
the CGN. The Texas population is diverse in ethnic makeup, and the TCGC
includes investigators with proven track records in assessing needs of the
Hispanic and African American communities in health care, in providing
health education to those communities and their healthcare providers, and in
recruiting their participation in familial cancer registries and clinical
and research studies. Funding of this application would provide the
opportunity for our TCGC to strengthen our within consortium interactions,
to contribute our research experience and expertise to the CGN design and
implementation, and to utilize our experience and expertise in recruitment
of high risk patients to CGN protocols. The long term goal is to contribute
to the identification of cancer susceptibility genes, their mechanisms of
action, frequency, penetrance, and genetic or environmental risk modifiers,
to integrate this information into optimal patient management, and to assess
needs and provide education to address the ethical and psychosocial concerns
surrounding human cancer genetics.
Publications
The psychosocial effects of the Li-Fraumeni Education and Early Detection (LEAD) program on individuals with Li-Fraumeni syndrome.
Authors: Ross J.
, Bojadzieva J.
, Peterson S.
, Noblin S.J.
, Yzquierdo R.
, Askins M.
, Strong L.
.
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2017 Sep; 19(9), p. 1064-1070.
EPub date: 2017-03-16 00:00:00.0.
PMID: 28301458
Related Citations
Early Detection Of Ovarian Cancer Using The Risk Of Ovarian Cancer Algorithm With Frequent Ca125 Testing In Women At Increased Familial Risk - Combined Results From Two Screening Trials
Authors: Skates S.J.
, Greene M.H.
, Buys S.S.
, Mai P.L.
, Brown P.H.
, Piedmonte M.
, Rodriguez G.C.
, Schorge J.O.
, Sherman M.
, Daly M.B.
, et al.
.
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2017-01-31 00:00:00.0; , .
PMID: 28143870
Related Citations
Long-term risk of medical conditions associated with breast cancer treatment.
Authors: Hill D.A.
, Horick N.K.
, Isaacs C.
, Domchek S.M.
, Tomlinson G.E.
, Lowery J.T.
, Kinney A.Y.
, Berg J.S.
, Edwards K.L.
, Moorman P.G.
, et al.
.
Source: Breast Cancer Research And Treatment, 2014 May; 145(1), p. 233-43.
PMID: 24696430
Related Citations
Increased Oxidative Metabolism In The Li-fraumeni Syndrome
Authors: Wang P.Y.
, Ma W.
, Park J.Y.
, Celi F.S.
, Arena R.
, Choi J.W.
, Ali Q.A.
, Tripodi D.J.
, Zhuang J.
, Lago C.U.
, et al.
.
Source: The New England Journal Of Medicine, 2013-03-14 00:00:00.0; 368(11), p. 1027-32.
PMID: 23484829
Related Citations
Activating mutation in MET oncogene in familial colorectal cancer.
Authors: Neklason D.W.
, Done M.W.
, Sargent N.R.
, Schwartz A.G.
, Anton-Culver H.
, Griffin C.A.
, Ahnen D.J.
, Schildkraut J.M.
, Tomlinson G.E.
, Strong L.C.
, et al.
.
Source: Bmc Cancer, 2011-10-04 00:00:00.0; 11, p. 424.
EPub date: 2011-10-04 00:00:00.0.
PMID: 21970370
Related Citations
Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status.
Authors: Skates S.J.
, Mai P.
, Horick N.K.
, Piedmonte M.
, Drescher C.W.
, Isaacs C.
, Armstrong D.K.
, Buys S.S.
, Rodriguez G.C.
, Horowitz I.R.
, et al.
.
Source: Cancer Prevention Research (philadelphia, Pa.), 2011 Sep; 4(9), p. 1401-8.
PMID: 21893500
Related Citations
Clinically relevant changes in family history of cancer over time.
Authors: Ziogas A.
, Horick N.K.
, Kinney A.Y.
, Lowery J.T.
, Domchek S.M.
, Isaacs C.
, Griffin C.A.
, Moorman P.G.
, Edwards K.L.
, Hill D.A.
, et al.
.
Source: Jama, 2011-07-13 00:00:00.0; 306(2), p. 172-8.
PMID: 21750294
Related Citations
Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis.
Authors: Neklason D.W.
, Kerber R.A.
, Nilson D.B.
, Anton-Culver H.
, Schwartz A.G.
, Griffin C.A.
, Lowery J.T.
, Schildkraut J.M.
, Evans J.P.
, Tomlinson G.E.
, et al.
.
Source: Cancer Research, 2008-11-01 00:00:00.0; 68(21), p. 8993-7.
PMID: 18974144
Related Citations
Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
Authors: Kerber R.A.
, Amos C.I.
, Yeap B.Y.
, Finkelstein D.M.
, Thomas D.C.
.
Source: Bmc Medical Genetics, 2008-07-10 00:00:00.0; 9, p. 64.
EPub date: 2008-07-10 00:00:00.0.
PMID: 18616822
Related Citations
Successful Strategies For Increasing African American Participation In Cancer Genetic Studies: Hopeful Signs For Equalizing The Benefits Of Genetic Medicine
Authors: Patterson A.R.
, Davis H.
, Shelby K.
, McCoy J.
, Robinson L.D.
, Rao S.K.
, Banerji P.
, Tomlinson G.E.
.
Source: Community Genetics, 2008; 11(4), p. 208-14.
PMID: 18417968
Related Citations
Assessing Brca Carrier Probabilities In Extended Families
Authors: Barcenas C.H.
, Hosain G.M.
, Arun B.
, Zong J.
, Zhou X.
, Chen J.
, Cortada J.M.
, Mills G.B.
, Tomlinson G.E.
, Miller A.R.
, et al.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2006-01-20 00:00:00.0; 24(3), p. 354-60.
PMID: 16421416
Related Citations
Assay Validation For Identification Of Hereditary Nonpolyposis Colon Cancer-causing Mutations In Mismatch Repair Genes Mlh1, Msh2, And Msh6
Authors: Hegde M.
, Blazo M.
, Chong B.
, Prior T.
, Richards C.
.
Source: The Journal Of Molecular Diagnostics : Jmd, 2005 Oct; 7(4), p. 525-34.
PMID: 16237223
Related Citations
Inherited Susceptibility For Pediatric Cancer
Authors: Plon S.E.
, Nathanson K.
.
Source: Cancer Journal (sudbury, Mass.), 2005 Jul-Aug; 11(4), p. 255-67.
PMID: 16197716
Related Citations
Recruitment For Breast Cancer Predisposition Studies In An Underserved African American Population
Authors: Patterson A.
, Davis H.
, Euhus D.
, Neuhausen S.
, Strong L.
, Tomlinson G.
.
Source: The Breast Journal, 2005 Jan-Feb; 11(1), p. 79-82.
PMID: 15647088
Related Citations
Genotype-phenotype Correlations In Peutz-jeghers Syndrome
Authors: Amos C.I.
, Keitheri-Cheteri M.B.
, Sabripour M.
, Wei C.
, McGarrity T.J.
, Seldin M.F.
, Nations L.
, Lynch P.M.
, Fidder H.H.
, Friedman E.
, et al.
.
Source: Journal Of Medical Genetics, 2004 May; 41(5), p. 327-33.
PMID: 15121768
Related Citations
Limb Girdle Muscular Dystrophy: Use Of Dhplc And Direct Sequencing To Detect Sarcoglycan Gene Mutations In A New Zealand Cohort
Authors: Love D.R.
.
Source: Clinical Genetics, 2004 Jan; 65(1), p. 55-60.
PMID: 15032976
Related Citations
Primary Care Physicians' Attitudes And Practices Regarding Cancer Genetics: A Comparison Of 2001 With 1996 Survey Results
Authors: Friedman L.
, Cooper H.P.
, Webb J.A.
, Weinberg A.D.
, Plon S.E.
.
Source: Journal Of Cancer Education : The Official Journal Of The American Association For Cancer Education, 2003 Summer; 18(2), p. 91-4.
PMID: 12888383
Related Citations
Re: On the use of familial aggregation in population-based case probands for calculating penetrance.
Authors: Amos C.I.
.
Source: Journal Of The National Cancer Institute, 2003-01-01 00:00:00.0; 95(1), p. 74-5; author reply 77-8.
PMID: 12509406
Related Citations
Positional identification of microdeletions with genetic markers.
Authors: Amos C.I.
, Shete S.
, Chen J.
, Yu R.K.
.
Source: Human Heredity, 2003; 56(1-3), p. 107-18.
PMID: 14614244
Related Citations
Counseling The At Risk Patient In The Brca1 And Brca2 Era
Authors: Barnes-Kedar I.M.
, Plon S.E.
.
Source: Obstetrics And Gynecology Clinics Of North America, 2002 Jun; 29(2), p. 341-66, vii.
PMID: 12108833
Related Citations
Detection Of Sequence Variations In The Adenomatous Polyposis Coli (apc) Gene Using Denaturing High-performance Liquid Chromatography
Authors: Wu G.
, Wu W.
, Hegde M.
, Fawkner M.
, Chong B.
, Love D.
, Su L.K.
, Lynch P.
, Snow K.
, Richards C.S.
.
Source: Genetic Testing, 2001 Winter; 5(4), p. 281-90.
PMID: 11960572
Related Citations
Mammography Behavior After Receiving A Negative Brca1 Mutation Test Result In The Ashkenazim: A Community-based Study
Authors: Plon S.E.
, Peterson L.E.
, Friedman L.C.
, Richards C.S.
.
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2000 Nov-Dec; 2(6), p. 307-11.
PMID: 11339650
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