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Grant Details

Grant Number: 5U01CA078124-04 Interpret this number
Primary Investigator: Osmond, Dennis
Organization: Univ Of California At San Francisco
Project Title: Natural History and Transmission of Hhv8/Kshv
Fiscal Year: 2001
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Abstract

DESCRIPTION (adapted from the Abstract): A multidisciplinary, four-year prospective study of the transmission and natural history of human herpes virus is proposed to (1) identify biologic and behavioral risk factors for acquisition of HHV-8/KSHV infection and (2) describe patterns for HHV- 8/KSHV virologic activity, types of host immunologic response, and the relationship of virologic activity and host response to the development of Kaposi's sarcoma (KS). The natural history of HHV-8/KSHV infection will be characterized in patients with and without HIV infection by (a) qualitative and quantitative longitudinal polymerase chain reaction measurement of HHV-8/KSHV in plasma, peripheral blood mononuclear cells, semen and saliva, (b) description of the evolution of anti-latency and anti-lytic phase associated antibodies to HHV-8/KSHV, (c) examination of host cytotoxic T-lymphocyte responses to HHV-8/KSHV at varying stages of infection, and (d) ascertainment of the temporal relationships between virologic activity, host responses, HIV infection, and the development of KS. Two existing cohorts of homosexual men, the San Francisco Men's Health Study and the San Francisco Young Men's Health Study, will be used to identify new seroconversions for antibodies to HHV-8/KSHV latency- associated nuclear antigens (LANA) and to obtain prospective samples of blood, semen, and saliva from men with pre-existing HHV-8/KSHV infection for varying duration, including men who have been seropositive since, at least, 1984. The researchers will follow 300 young men without prior evidence of HHV-8/KSHV infection, or whom 40 are HIV-infected, for the development of anti-LANA seroconversion. Between 35 and 40 incident infections are expected over the four years of follow-up. The natural history of infection will be observed in 200 men with pre-existing HHV- 8/KSHV infection; 100 of these are HIV co-infected.

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Publications

Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt".
Authors: Dollard S.C. , Butler L.M. , Jones A.M. , Mermin J.H. , Chidzonga M. , Chipato T. , Shiboski C.H. , Brander C. , Mosam A. , Kiepiela P. , et al. .
Source: International journal of cancer, 2010-11-15; 127(10), p. 2395-401.
PMID: 20143397
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Use of saliva as a lubricant in anal sexual practices among homosexual men.
Authors: Butler L.M. , Osmond D.H. , Jones A.G. , Martin J.N. .
Source: Journal of acquired immune deficiency syndromes (1999), 2009-02-01; 50(2), p. 162-7.
PMID: 19131893
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Awareness of Kaposi's sarcoma-associated herpesvirus among men who have sex with men.
Authors: Phillips A.M. , Jones A.G. , Osmond D.H. , Pollack L.M. , Catania J.A. , Martin J.N. .
Source: Sexually transmitted diseases, 2008 Dec; 35(12), p. 1011-4.
PMID: 18665016
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Oral candidiasis as a marker of HIV disease progression among Zimbabwean women.
Authors: Chidzonga M.M. , Mwale M. , Malvin K. , Martin J.N. , Greenspan J.S. , Shiboski C.H. .
Source: Journal of acquired immune deficiency syndromes (1999), 2008-04-15; 47(5), p. 579-84.
PMID: 18176326
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Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.
Authors: Woodberry T. , Suscovich T.J. , Henry L.M. , Martin J.N. , Dollard S. , O'Connor P.G. , Davis J.K. , Osmond D. , Lee T.H. , Kedes D.H. , et al. .
Source: The Journal of infectious diseases, 2005-08-15; 192(4), p. 622-9.
EPub date: 2005-07-15.
PMID: 16028131
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Decline in HIV infectivity following the introduction of highly active antiretroviral therapy.
Authors: Porco T.C. , Martin J.N. , Page-Shafer K.A. , Cheng A. , Charlebois E. , Grant R.M. , Osmond D.H. .
Source: AIDS (London, England), 2004-01-02; 18(1), p. 81-8.
PMID: 15090833
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Diagnosis and epidemiology of human herpesvirus 8 infection.
Authors: Martin J.N. .
Source: Seminars in hematology, 2003 Apr; 40(2), p. 133-42.
PMID: 12704590
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Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic.
Authors: Osmond D.H. , Buchbinder S. , Cheng A. , Graves A. , Vittinghoff E. , Cossen C.K. , Forghani B. , Martin J.N. .
Source: JAMA, 2002-01-09; 287(2), p. 221-5.
PMID: 11779265
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Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.
Authors: Brander C. , O'Connor P. , Suscovich T. , Jones N.G. , Lee Y. , Kedes D. , Ganem D. , Martin J. , Osmond D. , Southwood S. , et al. .
Source: The Journal of infectious diseases, 2001-07-15; 184(2), p. 119-26.
EPub date: 2001-06-18.
PMID: 11424007
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Invited commentary: determining specific sexual practices associated with human herpesvirus 8 transmission.
Authors: Martin J.N. , Osmond D.H. .
Source: American journal of epidemiology, 2000-02-01; 151(3), p. 225-9; discussion 230.
PMID: 10670546
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Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies.
Authors: Martin J.N. , Amad Z. , Cossen C. , Lam P.K. , Kedes D.H. , Page-Shafer K.A. , Osmond D.H. , Forghani B. .
Source: Journal of clinical microbiology, 2000 Feb; 38(2), p. 696-701.
PMID: 10655369
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