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Grant Details

Grant Number: 5R01CA075332-05 Interpret this number
Primary Investigator: Thomas, David
Organization: Fred Hutchinson Cancer Research Center
Project Title: Diet, Cell Proliferation and Breast Cancer in Shanghai
Fiscal Year: 2001
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Abstract

DESCRIPTION: The assumption on which this application is based is that factors that enhance mammary cell proliferation act to promote the development of breast cancer, and factors that inhibit proliferation serve as anti-promoters. Several dietary factors have been posited to influence mammary epithelial cell proliferation. The overall goals of the proposed study are to identify associations between various dietary factors and proliferation, as demonstrated histologically and by direct tissue assays, in benign fibrocystic breast lesions and in the mammary epithelium adjacent to both benign and malignant breast tumors. There are also plans to compare dietary factors in women with malignant and proliferative benign breast lesions, accounting for histologic evidence of proliferative changes in the surrounding non-tumorous tissue. Study subjects will be selected from among over 267,000 female textile workers in Shanghai, who were enrolled in 1988-89 in a randomized trial of breast self-examination (BSE). Women in this cohort, who, during a 5-year period, develop breast cancer or fibrocystic lesions, and normal age-matched controls selected from the cohort, will be interviewed to obtain information on risk factors for breast cancer, frequency of intake of multiple foods, recent dietary changes and recent intake of phytoestrogen-rich foods. All data will be gathered prior to diagnosis. Blood specimens will be collected and assayed for various lipids, antioxidant vitamins, and isoflavones. Histologic slides from all cases will be collected, the lesions will be classified, and both the benign lesions and normal tissue will be evaluated for various morphologic and immunocytochemical indicators of ductal and lobular proliferation. Unlike prior studies, consumption of foods in this study sample covers a range over which not only breast cancer rates are expected to vary widely, but also phytoestrogen consumption is high, providing an opportunity to evaluate their role in breast cancer. Also unlike prior epidemiologic studies of diet and breast cancer, in the proposed investigation the primary end points are various indices of cell proliferation.

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Publications

Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China.
Authors: Atkinson C. , Ray R.M. , Li W. , Lin M.G. , Gao D.L. , Shannon J. , Stalsberg H. , Porter P.L. , Frankenfeld C.L. , Wähälä K. , et al. .
Source: Nutrition research (New York, N.Y.), 2016 08; 36(8), p. 863-71.
EPub date: 2016-03-30.
PMID: 27440541
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Fruit and vegetable intakes in relation to plasma nutrient concentrations in women in Shanghai, China.
Authors: Frankenfeld C.L. , Lampe J.W. , Shannon J. , Gao D.L. , Li W. , Ray R.M. , Chen C. , King I.B. , Thomas D.B. .
Source: Public health nutrition, 2012 Jan; 15(1), p. 167-75.
EPub date: 2011-06-06.
PMID: 21729475
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Biomarkers of dietary exposure are associated with lower risk of breast fibroadenomas in Chinese women.
Authors: Dijkstra S.C. , Lampe J.W. , Ray R.M. , Brown R. , Wu C. , Li W. , Chen C. , King I.B. , Gao D. , Hu Y. , et al. .
Source: The Journal of nutrition, 2010 Jul; 140(7), p. 1302-10.
EPub date: 2010-05-19.
PMID: 20484550
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Fruit and vegetable intakes are associated with lower risk of breast fibroadenomas in Chinese women.
Authors: Nelson Z.C. , Ray R.M. , Wu C. , Stalsberg H. , Porter P. , Lampe J.W. , Shannon J. , Horner N. , Li W. , Wang W. , et al. .
Source: The Journal of nutrition, 2010 Jul; 140(7), p. 1294-301.
EPub date: 2010-05-19.
PMID: 20484549
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Dietary and stored iron as predictors of breast cancer risk: A nested case-control study in Shanghai.
Authors: Moore A.B. , Shannon J. , Chen C. , Lampe J.W. , Ray R.M. , Lewis S.K. , Lin M. , Stalsberg H. , Thomas D.B. .
Source: International journal of cancer, 2009-09-01; 125(5), p. 1110-7.
PMID: 19444907
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Erythrocyte fatty acids and risk of proliferative and nonproliferative fibrocystic disease in women in Shanghai, China.
Authors: Shannon J. , King I.B. , Lampe J.W. , Gao D.L. , Ray R.M. , Lin M.G. , Stalsberg H. , Thomas D.B. .
Source: The American journal of clinical nutrition, 2009 Jan; 89(1), p. 265-76.
EPub date: 2008-12-03.
PMID: 19056601
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Plasma isoflavones and fibrocystic breast conditions and breast cancer among women in Shanghai, China.
Authors: Lampe J.W. , Nishino Y. , Ray R.M. , Wu C. , Li W. , Lin M.G. , Gao D.L. , Hu Y. , Shannon J. , Stalsberg H. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007 Dec; 16(12), p. 2579-86.
PMID: 18086761
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Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China.
Authors: Shannon J. , King I.B. , Moshofsky R. , Lampe J.W. , Gao D.L. , Ray R.M. , Thomas D.B. .
Source: The American journal of clinical nutrition, 2007 Apr; 85(4), p. 1090-7.
PMID: 17413110
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Dietary and other risk factors in women having fibrocystic breast conditions with and without concurrent breast cancer: a nested case-control study in Shanghai, China.
Authors: Li W. , Ray R.M. , Lampe J.W. , Lin M.G. , Gao D.L. , Wu C. , Nelson Z.C. , Fitzgibbons E.D. , Horner N. , Hu Y.W. , et al. .
Source: International journal of cancer, 2005-07-20; 115(6), p. 981-93.
PMID: 15723298
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Food and botanical groupings and risk of breast cancer: a case-control study in Shanghai, China.
Authors: Shannon J. , Ray R. , Wu C. , Nelson Z. , Gao D.L. , Li W. , Hu W. , Lampe J. , Horner N. , Satia J. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005 Jan; 14(1), p. 81-90.
PMID: 15668480
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