DESCRIPTION: This is a competing continuation application for continued study
of human papilloma virus (HPV) genital persistent in a large cohort of low
income women in Sao Paolo, Brazil, a high risk area for cervical carcinoma. The
study focuses on the relationship of oncogenic HPV types on the development of
cervical epithelial lesions and carcinoma. Participants undergo a series of
questionnaire-based interviews to access sexual behavior and other potentially
contributing factors, PAP smears, HPV testing by PCR, HPV serology and
cervicography. The objectives are to
1 study incidence and prevalence of persistent cervical HPV in
asymptomatic women;
2 verify the hypothesis that persistent HPV increases low and high
grade cervical lesions;
3 detect epidemiological determinants of HPV persistence;
4 search for molecular variants associated with cervical lesions;
5 to determine whether HPV viral load is associated with persistence,
and low or high grade lesions; and
6 study the role of antibody response to HPV persistence and lesion
progression.
For the competitive renewal, 2 additional aims are proposed:
7 identity HLA haplotypes associated with HPV persistence and cervical
lesions; and
8 test whether p53 polymorphisms confer resistance to HPV persistence
and lesion development.
Error Notice
The database may currently be offline for maintenance and should be operational soon. If not, we have been notified of this error and will be reviewing it shortly.
We apologize for the inconvenience.
- The DCCPS Team.
