Grant Number:	5P01CA069266-05 Interpret this number
Primary Investigator:	Mueller, Nancy
Organization:	Harvard University (Sch Of Public Hlth)
Project Title:	Viral Etiology of Hodgkins Disease
Fiscal Year:	2001

Recent findings on Hodgkin's disease (HD) present a number of important questions. The established risk factors point to age of infection as an important modifier of risk. Cases have altered antibody profiles to the Epstein-Barr virus (EBV) preceding and following diagnosis. The new finding is that 30-50% of HD cases' tumors contain monoclonal EBV genome, with a restricted latent protein expression. How these risk factor, serologic, and molecular data fit together and whether EBV-genome negative HD represents a separate etiology are unknown. This Program Project is designed to test three alternate models of the role of the EBV in the pathogenesis of HD: the EBV is solely related to EBV-genome positive HD with EBV-genome negative disease due to non-viral causes; HD is a virally induced malignancy with the EBV responsible for EBV-genome positive disease and another unidentified virus(es) linked to EBV- genome negative disease; or the EBV plays a crucial early role in the pathogenesis of essentially all HD cases but the genome is selectively lost in some patients. Three companion projects will address the following: the role of EBV in the epidemiology of HD (600 cases and 600 population controls); the association of pre- diagnosis EBV serology with EBV genome status of tumor biopsy in HD (200 cases and 200 matched controls); and characterization of the EBV infection and the cellular immune response in HD cases (160 cases and 160 bone marrow donor controls). The Projects are supported by a serology/pathology Core and an Administrative Core. The combined mutually standardized data from the population studies, plus extensive biomarkers including EBV serology and viral probes, and detailed immunologic markers will result in a substantial and rich database. The program brings together an experienced multi- disciplinary group of investigators; by working together we should gain insight into the etiology of HD.




Elevated Serum Levels Of Scd30 And Il-6 And Detectable Il-10 Precede Classical Hodgkin Lymphoma Diagnosis
Authors: Levin L.I. , Breen E.C. , Birmann B.M. , Batista J.L. , Magpantay L.I. , Li Y. , Ambinder R.F. , Mueller N.E. , Martínez-Maza O. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-03-24 00:00:00.0; , .
PMID: 28341757
Related Citations

Dietary Pattern And Risk Of Hodgkin Lymphoma In A Population-based Case-control Study
Authors: Epstein M.M. , Chang E.T. , Zhang Y. , Fung T.T. , Batista J.L. , Ambinder R.F. , Zheng T. , Mueller N.E. , Birmann B.M. .
Source: American Journal Of Epidemiology, 2015-09-01 00:00:00.0; 182(5), p. 405-16.
PMID: 26182945
Related Citations

Subtype Of Dietary Fat In Relation To Risk Of Hodgkin Lymphoma: A Population-based Case-control Study In Connecticut And Massachusetts
Authors: Gao Y. , Li Q. , Bassig B.A. , Chang E.T. , Dai M. , Qin Q. , Zhang Y. , Zheng T. .
Source: Cancer Causes & Control : Ccc, 2013 Mar; 24(3), p. 485-94.
PMID: 23314676
Related Citations

Body Size And Risk Of Hodgkin's Lymphoma By Age And Gender: A Population-based Case-control Study In Connecticut And Massachusetts
Authors: Li Q. , Chang E.T. , Bassig B.A. , Dai M. , Qin Q. , Gao Y. , Zhang Y. , Zheng T. .
Source: Cancer Causes & Control : Ccc, 2013 Feb; 24(2), p. 287-95.
PMID: 23208661
Related Citations

Atypical Prediagnosis Epstein-barr Virus Serology Restricted To Ebv-positive Hodgkin Lymphoma
Authors: Levin L.I. , Chang E.T. , Ambinder R.F. , Lennette E.T. , Rubertone M.V. , Mann R.B. , Borowitz M. , Weir E.G. , Abbondanzo S.L. , Mueller N.E. .
Source: Blood, 2012-11-01 00:00:00.0; 120(18), p. 3750-5.
PMID: 22972983
Related Citations

Nutrients And Genetic Variation Involved In One-carbon Metabolism And Hodgkin Lymphoma Risk: A Population-based Case-control Study
Authors: Kasperzyk J.L. , Chang E.T. , Birmann B.M. , Kraft P. , Zheng T. , Mueller N.E. .
Source: American Journal Of Epidemiology, 2011-10-01 00:00:00.0; 174(7), p. 816-27.
PMID: 21810727
Related Citations

Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.
Authors: Chang E.T. , Birmann B.M. , Kasperzyk J.L. , Conti D.V. , Kraft P. , Ambinder R.F. , Zheng T. , Mueller N.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Mar; 18(3), p. 976-86.
PMID: 19223558
Related Citations

Bortezomib-induced Enzyme-targeted Radiation Therapy In Herpesvirus-associated Tumors
Authors: Fu D.X. , Tanhehco Y. , Chen J. , Foss C.A. , Fox J.J. , Chong J.M. , Hobbs R.F. , Fukayama M. , Sgouros G. , Kowalski J. , et al. .
Source: Nature Medicine, 2008 Oct; 14(10), p. 1118-22.
PMID: 18776891
Related Citations

Childhood Social Environment And Hodgkin's Lymphoma: New Findings From A Population-based Case-control Study
Authors: Chang E.T. , Zheng T. , Weir E.G. , Borowitz M. , Mann R.B. , Spiegelman D. , Mueller N.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2004 Aug; 13(8), p. 1361-70.
PMID: 15298959
Related Citations

Heterogeneity Of Risk Factors And Antibody Profiles In Epstein-barr Virus Genome-positive And -negative Hodgkin Lymphoma
Authors: Chang E.T. , Zheng T. , Lennette E.T. , Weir E.G. , Borowitz M. , Mann R.B. , Spiegelman D. , Mueller N.E. .
Source: The Journal Of Infectious Diseases, 2004-06-15 00:00:00.0; 189(12), p. 2271-81.
PMID: 15181575
Related Citations

Aspirin And The Risk Of Hodgkin's Lymphoma In A Population-based Case-control Study
Authors: Chang E.T. , Zheng T. , Weir E.G. , Borowitz M. , Mann R.B. , Spiegelman D. , Mueller N.E. .
Source: Journal Of The National Cancer Institute, 2004-02-18 00:00:00.0; 96(4), p. 305-15.
PMID: 14970279
Related Citations

Frequent Expression Of The Tumor Necrosis Factor Receptor-associated Factor 1 In Latent Membrane Protein 1-positive Posttransplant Lymphoproliferative Disease And Hiv-associated Lymphomas
Authors: Murray P.G. , Swinnen L.J. , Flavell J.R. , Ragni M.V. , Baumforth K.R. , Toomey S.M. , Filipovich A.H. , Lowe D. , Schnell C.S. , Johl J. , et al. .
Source: Human Pathology, 2001 Sep; 32(9), p. 963-9.
PMID: 11567226
Related Citations

Linkage Between Stat Regulation And Epstein-barr Virus Gene Expression In Tumors
Authors: Chen H. , Lee J.M. , Zong Y. , Borowitz M. , Ng M.H. , Ambinder R.F. , Hayward S.D. .
Source: Journal Of Virology, 2001 Mar; 75(6), p. 2929-37.
PMID: 11222718
Related Citations

Epstein-barr Virus Bamhi-a Rightward Transcript-encoded Rpms Protein Interacts With The Cbf1-associated Corepressor Cir To Negatively Regulate The Activity Of Ebna2 And Notchic
Authors: Zhang J. , Chen H. , Weinmaster G. , Hayward S.D. .
Source: Journal Of Virology, 2001 Mar; 75(6), p. 2946-56.
PMID: 11222720
Related Citations

Epstein-barr Virus In Hodgkin's Disease: Correlation Of Risk Factors And Disease Characteristics With Molecular Evidence Of Viral Infection
Authors: Sleckman B.G. , Mauch P.M. , Ambinder R.F. , Mann R. , Pinkus G.S. , Kadin M.E. , Sherburne B. , Perez-Atayde A. , Thior I. , Mueller N. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1998 Dec; 7(12), p. 1117-21.
PMID: 9865430
Related Citations

Analysis Of Major Histocompatibility Complex Class I, Tap Expression, And Lmp2 Epitope Sequence In Epstein-barr Virus-positive Hodgkin's Disease
Authors: Murray P.G. , Constandinou C.M. , Crocker J. , Young L.S. , Ambinder R.F. .
Source: Blood, 1998-10-01 00:00:00.0; 92(7), p. 2477-83.
PMID: 9746788
Related Citations