Grant Number:	5R01CA063030-07 Interpret this number
Primary Investigator:	Syrjala, Karen
Organization:	Fred Hutchinson Cancer Research Center
Project Title:	Enhancing Recovery From Blood and Marrow Transplantation
Fiscal Year:	2001

This is a resubmission of a competing continuation application: R01 CA 63030. This proposal would test a behavioral and interdisciplinary triage team intervention for blood and marrow transplantation (BMT) survivors which is cost and resource conserving and can be made available to virtually any survivor. The proposed design is a randomized controlled clinical trial in a consortium, with national multi-site accrual (N= 386 accrued pretransplant; 230 surviving to one year follow-up). Family caregivers are accrued where identifiable. Based on our prior research, we have targeted the dominant areas of long-term concern for a majority of BMT survivors. The study prescribes intervention early, after patients return home to widely divergent community resources, and before problems develop into maladaptive patterns that sustain long-term impairments. Specific aims are to determine whether the intervention package assists transplant recipients and their families in: 1) managing rehabilitation needs including reduced stamina and cognitive limitations; 2) adjusting to fluctuations in family roles and emotions; and 3) managing menopausal symptoms and sexual function changes (for women only). Male and female adult survivors, with a primary caregiver, will receive one of two interventions: I.) Standard Treatment consisting of usual discharge preparation at each BMT site prior to return home; or II.) An Intervention Package consisting of nine (for men) or ten (for women) psychoeducational telephone counseling sessions over the year after return home from transplant. Problems identified with the telephone counselor will be triaged for additional assessment and resource activation by a study nurse. Assessments include pre- and post-transplant baselines prior to randomization and intervention, with one and two year follow-up assessments to evaluate the intervention efficacy. Primary hypotheses include that survivors who participate in the intervention will have improved function in the targeted areas and that this improvement will be mediated through increased use of active coping strategies. This research builds directly on the work of the previous grant cycle by extending the prior specific aims to a wider group of patients through an improved methodology. The BMT setting provides a well-standardized environment in which to test interventions that will be applicable to both the ever-increasing numbers of transplantation survivors and other populations of cancer survivors.




Psychometric properties of the Cancer and Treatment Distress (CTXD) measure in hematopoietic cell transplantation patients.
Authors: Syrjala K.L. , Yi J.C. , Langer S.L. .
Source: Psycho-oncology, 2016 May; 25(5), p. 529-35.
PMID: 26130497
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Prospective Neurocognitive Function Over 5 Years After Allogeneic Hematopoietic Cell Transplantation For Cancer Survivors Compared With Matched Controls At 5 Years
Authors: Syrjala K.L. , Artherholt S.B. , Kurland B.F. , Langer S.L. , Roth-Roemer S. , Elrod J.B. , Dikmen S. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2011-06-10 00:00:00.0; 29(17), p. 2397-404.
PMID: 21537032
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Pre- And Post-transplantation Risk Factors For Delirium Onset And Severity In Patients Undergoing Hematopoietic Stem-cell Transplantation
Authors: Fann J.R. , Hubbard R.A. , Alfano C.M. , Roth-Roemer S. , Katon W.J. , Syrjala K.L. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2011-03-01 00:00:00.0; 29(7), p. 895-901.
PMID: 21263081
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Impact Of Delirium On Decision-making Capacity After Hematopoietic Stem-cell Transplantation
Authors: Zaubler T. , Fann J.R. , Roth-Roemer S. , Katon W.J. , Bustami R. , Syrjala K.L. .
Source: Psychosomatics, 2010 Jul-Aug; 51(4), p. 320-9.
PMID: 20587760
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Impact Of Delirium On Distress, Health-related Quality Of Life, And Cognition 6 Months And 1 Year After Hematopoietic Cell Transplant
Authors: Basinski J.R. , Alfano C.M. , Katon W.J. , Syrjala K.L. , Fann J.R. .
Source: Biology Of Blood And Marrow Transplantation : Journal Of The American Society For Blood And Marrow Transplantation, 2010 Jun; 16(6), p. 824-31.
PMID: 20100587
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Prospective Predictors Of Return To Work In The 5 Years After Hematopoietic Cell Transplantation
Authors: Kirchhoff A.C. , Leisenring W. , Syrjala K.L. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2010 Mar; 4(1), p. 33-44.
PMID: 19936935
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Marital adjustment, satisfaction and dissolution among hematopoietic stem cell transplant patients and spouses: a prospective, five-year longitudinal investigation.
Authors: Langer S.L. , Yi J.C. , Storer B.E. , Syrjala K.L. .
Source: Psycho-oncology, 2010 Feb; 19(2), p. 190-200.
PMID: 19189319
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Sexuality After Hematopoietic Stem Cell Transplantation
Authors: Yi J.C. , Syrjala K.L. .
Source: Cancer Journal (sudbury, Mass.), 2009 Jan-Feb; 15(1), p. 57-64.
PMID: 19197175
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Physical and psychological long-term and late effects of cancer.
Authors: Stein K.D. , Syrjala K.L. , Andrykowski M.A. .
Source: Cancer, 2008-06-01 00:00:00.0; 112(11 Suppl), p. 2577-92.
PMID: 18428205
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Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy.
Authors: Butt Z. , Rosenbloom S.K. , Abernethy A.P. , Beaumont J.L. , Paul D. , Hampton D. , Jacobsen P.B. , Syrjala K.L. , Von Roenn J.H. , Cella D. .
Source: Journal Of The National Comprehensive Cancer Network : Jnccn, 2008 May; 6(5), p. 448-55.
PMID: 18492460
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Patient Training In Cancer Pain Management Using Integrated Print And Video Materials: A Multisite Randomized Controlled Trial
Authors: Syrjala K.L. , Abrams J.R. , Polissar N.L. , Hansberry J. , Robison J. , DuPen S. , Stillman M. , Fredrickson M. , Rivkin S. , Feldman E. , et al. .
Source: Pain, 2008 Mar; 135(1-2), p. 175-86.
PMID: 18093738
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Sexual Function Changes During The 5 Years After High-dose Treatment And Hematopoietic Cell Transplantation For Malignancy, With Case-matched Controls At 5 Years
Authors: Syrjala K.L. , Kurland B.F. , Abrams J.R. , Sanders J.E. , Heiman J.R. .
Source: Blood, 2008-02-01 00:00:00.0; 111(3), p. 989-96.
PMID: 17878404
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Fertility And Risk Factors For Elevated Infertility Concern In 10-year Hematopoietic Cell Transplant Survivors And Case-matched Controls
Authors: Hammond C. , Abrams J.R. , Syrjala K.L. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2007-08-10 00:00:00.0; 25(23), p. 3511-7.
PMID: 17646668
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Impact Of Delirium On Cognition, Distress, And Health-related Quality Of Life After Hematopoietic Stem-cell Transplantation
Authors: Fann J.R. , Alfano C.M. , Roth-Roemer S. , Katon W.J. , Syrjala K.L. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2007-04-01 00:00:00.0; 25(10), p. 1223-31.
PMID: 17401011
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Late Effects Of Hematopoietic Cell Transplantation Among 10-year Adult Survivors Compared With Case-matched Controls
Authors: Syrjala K.L. , Langer S.L. , Abrams J.R. , Storer B.E. , Martin P.J. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2005-09-20 00:00:00.0; 23(27), p. 6596-606.
PMID: 16170167
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Clinical Presentation Of Delirium In Patients Undergoing Hematopoietic Stem Cell Transplantation
Authors: Fann J.R. , Alfano C.M. , Burington B.E. , Roth-Roemer S. , Katon W.J. , Syrjala K.L. .
Source: Cancer, 2005-02-15 00:00:00.0; 103(4), p. 810-20.
PMID: 15643598
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Neuropsychologic changes from before transplantation to 1 year in patients receiving myeloablative allogeneic hematopoietic cell transplant.
Authors: Syrjala K.L. , Dikmen S. , Langer S.L. , Roth-Roemer S. , Abrams J.R. .
Source: Blood, 2004-11-15 00:00:00.0; 104(10), p. 3386-92.
EPub date: 2004-11-15 00:00:00.0.
PMID: 15251983
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Physicians' Attitudes About Quality-of-life Issues In Hematopoietic Stem Cell Transplantation
Authors: Lee S.J. , Joffe S. , Kim H.T. , Socie G. , Gilman A.L. , Wingard J.R. , Horowitz M.M. , Cella D. , Syrjala K.L. .
Source: Blood, 2004-10-01 00:00:00.0; 104(7), p. 2194-200.
PMID: 15198954
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Recovery And Long-term Function After Hematopoietic Cell Transplantation For Leukemia Or Lymphoma
Authors: Syrjala K.L. , Langer S.L. , Abrams J.R. , Storer B. , Sanders J.E. , Flowers M.E. , Martin P.J. .
Source: Jama, 2004-05-19 00:00:00.0; 291(19), p. 2335-43.
PMID: 15150205
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The Neuropsychology Of Cancer Treatment. Introduction
Authors: Syrjala K.L. .
Source: Seminars In Clinical Neuropsychiatry, 2003 Oct; 8(4), p. 197-200.
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Caregiver And Patient Marital Satisfaction And Affect Following Hematopoietic Stem Cell Transplantation: A Prospective, Longitudinal Investigation
Authors: Langer S. , Abrams J. , Syrjala K. .
Source: Psycho-oncology, 2003 Apr-May; 12(3), p. 239-53.
PMID: 12673808
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Delirium In Patients Undergoing Hematopoietic Stem Cell Transplantation
Authors: Fann J.R. , Roth-Roemer S. , Burington B.E. , Katon W.J. , Syrjala K.L. .
Source: Cancer, 2002-11-01 00:00:00.0; 95(9), p. 1971-81.
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Implementing Guidelines For Cancer Pain Management: Results Of A Randomized Controlled Clinical Trial
Authors: Du Pen S.L. , Du Pen A.R. , Polissar N. , Hansberry J. , Kraybill B.M. , Stillman M. , Panke J. , Everly R. , Syrjala K. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 1999 Jan; 17(1), p. 361-70.
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A Serial Study Of The Concentration Of Misonidazole In Human Tumors Correlated With Histologic Structure
Authors: Rich T.A. , Dische S. , Saunders M.I. , Stratford M.R. , Minchinton A. .
Source: International Journal Of Radiation Oncology, Biology, Physics, 1981 Feb; 7(2), p. 197-203.
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