DESCRIPTION: Polymorphisms in the CAG repeat length in the AR gene have
been demonstrated to correlate with risk of prostate cancer. Using blood
samples collected in 1993-94 from 18,000 men in the ongoing HPFS, in
combination with buccal brushings to be acquired from an additional 20,000
cohort members, there are plans to characterize risk of prostate cancer,
based on CAG polymorphisms in the AR gene. Then, using a nested
case-control design of approximately 1,000 projected cases from 1993-2000,
the impact of specific nutritional factors on prostate cancer risk will be
examined, stratifying across genetic risk. Specifically, associations of
diet and nutritional status (pre-adult adiposity and attained height) will
be examined with incidence of prostate cancer among men stratified by risk
according to number of CAG repeats in the AR gene. Then, an assessment will
be made of whether men at higher risk can potentially reduce their excess
risk by decreasing their consumption of animal fat and by increasing
lycopene and fiber intake, aspects of diet that have already been associated
with reduced risk in the overall cohort. Non-nutritional factors that are
hypothesized to influence testosterone levels will also be examined, in
particular physical activity and smoking, in relation to incidence of
prostate cancer among men, stratified by genetic risk according to AR
characteristics. A final Aim is to acquire buccal smears for DNA analyses
from HPFS participants who did not previously provide blood specimens. This
will complete the establishment of a large database consisting of a) updated
dietary and other exposure information over a 15 year period for 50,000 men,
b) stored DNA samples (blood or buccal brushing) from approximately 38,000
of these men, c) stored plasma from 18,000 participants, and d) archived
tissue from incident prostate cancers. The buccal brushings, along with
providing the basis for the specific aims in this application, will allow
for the rapid testing of future specific hypotheses.
If you are accessing this page during weekend or evening hours, the database may currently be offline for maintenance and should operational within a few hours. Otherwise, we have been notified of this error and will be addressing it immediately.
Please contact us
if this error persists.
We apologize for the inconvenience.
- The DCCPS Team.