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Grant Details

Grant Number: 5R01CA072787-05 Interpret this number
Primary Investigator: Daling, Janet
Organization: Fred Hutchinson Cancer Research Center
Project Title: Calcium Channel Blockers in Breast Cancer Etiology
Fiscal Year: 2001
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Abstract

DESCRIPTION: (Adapted from Applicant's Abstract). Although over one-third of all breast cancers are diagnosed among women aged 65-79 years, little epidemiologic research has specifically focussed on breast cancer in women of this age. Women of this age also commonly suffer from hypertension or coronary disease, and calcium channel blockers (CCBs) are often used to treat either of these conditions. Two recent studies, yet to be published, of women aged 65 and older, suggest that women who use CCBs may be at an increased risk of breast cancer. This suspected association is given biological plausibility by the observation that pharmacological blockade of the calcium channels can inhibit apoptosis (programmed cell death), the process whereby organisms eliminate unwanted cells (e.g., preneoplastic, initiated, damaged, excessive). In this sense, CCBs may be cancer promoters. The application proposes a case-control study of 1,000 women, aged 65-79, who reside in King County, Washington, who are on the Health Care Financing Administration (HCFA) tapes, and who are diagnosed with their first invasive breast cancer during the time period of January 1, 1997 through December 31, 1999. The personal interview responses of these women about drug use and other known risk factors for breast cancer will be compared to a control group of 1,000 women without breast cancer who will be identified through the HCFA tapes. Based on the preliminary studies and the evidence from in vitro studies on cells, it is posited that the use of CCBs increases the risk of breast cancer in older women. The plan is to assess whether calcium antagonists used in the treatment of hypertension and cardiovascular diseases promote breast cancer in women aged 65-79 years, and whether any one type of calcium channel blocker is more related to breast cancer than the other types. Since no studies have assessed present or past use of combined estrogen-progestin therapy in a large group of women this age, and the concurrent use of hormone replacement therapy (HRT) by these women may affect the proposed estimates of risk associated with CCBs, data will also be collected and analyzed on other drugs (viz., cimetidine, anti-depressants, lipid lowering drugs) frequently used by women in this age group.

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Publications

Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.
Authors: Resler A.J. , Malone K.E. , Johnson L.G. , Malkki M. , Petersdorf E.W. , McKnight B. , Madeleine M.M. .
Source: BMC cancer, 2013-05-01; 13, p. 219.
EPub date: 2013-05-01.
PMID: 23634849
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Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.
Authors: Madeleine M.M. , Johnson L.G. , Malkki M. , Resler A.J. , Petersdorf E.W. , McKnight B. , Malone K.E. .
Source: Breast cancer research and treatment, 2011 Oct; 129(3), p. 887-99.
EPub date: 2011-04-27.
PMID: 21523452
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Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.
Authors: Reding K.W. , Li C.I. , Weiss N.S. , Chen C. , Carlson C.S. , Duggan D. , Thummel K.E. , Daling J.R. , Malone K.E. .
Source: American journal of epidemiology, 2009-11-15; 170(10), p. 1241-9.
EPub date: 2009-10-21.
PMID: 19846565
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Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.
Authors: Reding K.W. , Weiss N.S. , Chen C. , Li C.I. , Carlson C.S. , Wilkerson H.W. , Farin F.M. , Thummel K.E. , Daling J.R. , Malone K.E. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009 May; 18(5), p. 1461-7.
EPub date: 2009-04-21.
PMID: 19383894
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Migraine in postmenopausal women and the risk of invasive breast cancer.
Authors: Mathes R.W. , Malone K.E. , Daling J.R. , Davis S. , Lucas S.M. , Porter P.L. , Li C.I. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Nov; 17(11), p. 3116-22.
PMID: 18990752
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Reproductive and hormonal risk factors for postmenopausal luminal, HER-2-overexpressing, and triple-negative breast cancer.
Authors: Phipps A.I. , Malone K.E. , Porter P.L. , Daling J.R. , Li C.I. .
Source: Cancer, 2008-10-01; 113(7), p. 1521-6.
PMID: 18726992
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Body size and risk of luminal, HER2-overexpressing, and triple-negative breast cancer in postmenopausal women.
Authors: Phipps A.I. , Malone K.E. , Porter P.L. , Daling J.R. , Li C.I. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008 Aug; 17(8), p. 2078-86.
EPub date: 2008-07-29.
PMID: 18664548
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Interactions between body mass index and hormone therapy and postmenopausal breast cancer risk (United States).
Authors: Li C.I. , Malone K.E. , Daling J.R. .
Source: Cancer causes & control : CCC, 2006 Jun; 17(5), p. 695-703.
PMID: 16633917
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The relationship between various measures of cigarette smoking and risk of breast cancer among older women 65-79 years of age (United States).
Authors: Li C.I. , Malone K.E. , Daling J.R. .
Source: Cancer causes & control : CCC, 2005 Oct; 16(8), p. 975-85.
PMID: 16132806
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The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: a case-control study.
Authors: Boudreau D.M. , Gardner J.S. , Malone K.E. , Heckbert S.R. , Blough D.K. , Daling J.R. .
Source: Cancer, 2004-06-01; 100(11), p. 2308-16.
PMID: 15160333
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Reproductive and anthropometric factors in relation to the risk of lobular and ductal breast carcinoma among women 65-79 years of age.
Authors: Li C.I. , Malone K.E. , Porter P.L. , Weiss N.S. , Tang M.T. , Daling J.R. .
Source: International journal of cancer, 2003-11-20; 107(4), p. 647-51.
PMID: 14520705
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The relationship between alcohol use and risk of breast cancer by histology and hormone receptor status among women 65-79 years of age.
Authors: Li C.I. , Malone K.E. , Porter P.L. , Weiss N.S. , Tang M.T. , Daling J.R. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003 Oct; 12(10), p. 1061-6.
PMID: 14578143
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Relation between use of antihypertensive medications and risk of breast carcinoma among women ages 65-79 years.
Authors: Li C.I. , Malone K.E. , Weiss N.S. , Boudreau D.M. , Cushing-Haugen K.L. , Daling J.R. .
Source: Cancer, 2003-10-01; 98(7), p. 1504-13.
PMID: 14508839
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Relationship between long durations and different regimens of hormone therapy and risk of breast cancer.
Authors: Li C.I. , Malone K.E. , Porter P.L. , Weiss N.S. , Tang M.T. , Cushing-Haugen K.L. , Daling J.R. .
Source: JAMA, 2003-06-25; 289(24), p. 3254-63.
PMID: 12824206
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Changing incidence rate of invasive lobular breast carcinoma among older women.
Authors: Li C.I. , Anderson B.O. , Porter P. , Holt S.K. , Daling J.R. , Moe R.E. .
Source: Cancer, 2000-06-01; 88(11), p. 2561-9.
PMID: 10861434
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