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Grant Details

Grant Number: 5R01CA075977-04 Interpret this number
Primary Investigator: Weiss, Noel
Organization: Fred Hutchinson Cancer Research Center
Project Title: Endometrial Cancer and Postmenopausal Hormone Therapy
Fiscal Year: 2001
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Abstract

DESCRIPTION: The increased risk of endometrial cancer associated with the use of postmenopausal estrogen therapy can be diminished by the concomitant use of progestogen on a cyclic basis. Nevertheless, it is quite uncertain whether the entirety of the increased risk is eliminated, especially in long-term users of cyclic estrogen/progestogen regimens. Additionally, the impact on endometrial cancer incidence of a now-common way of taking hormones, on a combined-continuous basis, has never been evaluated. To address these questions, a population-based case-control study of endometrial cancer is proposed for women 50-60 years of age who reside in three counties of western Washington. An attempt will be made to interview eligible cases diagnosed during 1997-1999 regarding the use of hormonal medications and other exposures and characteristics that bear on the incidence of endometrial cancer. As a basis of comparison for the cases who are 50-64 years of age, interviews will be sough with 50-64 year-old female residents of these counties identified through random digit dialing. Controls 65-69 years of age will be identified through the records of the Health Care Financing Administration, and they will be interviewed as well. Potential controls who have previously had a hysterectomy will be excluded. We anticipate obtaining interviews with approximately 300 cases and an equal number of controls. Exogenous hormones offer postmenopausal women substantial benefits with regard to their cardiovascular and skeletal systems. The proposed study has the potential to obtain information that can guide their choice of hormonal regimen so as to minimize the likelihood of endometrial cancer as an adverse effect of this otherwise useful therapy.

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Publications

Intrauterine devices and endometrial cancer risk: a pooled analysis of the Epidemiology of Endometrial Cancer Consortium.
Authors: Felix A.S. , Gaudet M.M. , La Vecchia C. , Nagle C.M. , Shu X.O. , Weiderpass E. , Adami H.O. , Beresford S. , Bernstein L. , Chen C. , et al. .
Source: International journal of cancer, 2015-03-01; 136(5), p. E410-22.
EPub date: 2014-09-30.
PMID: 25242594
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Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2).
Authors: Cote M.L. , Alhajj T. , Ruterbusch J.J. , Bernstein L. , Brinton L.A. , Blot W.J. , Chen C. , Gass M. , Gaussoin S. , Henderson B. , et al. .
Source: Cancer causes & control : CCC, 2015 Feb; 26(2), p. 287-296.
EPub date: 2014-12-23.
PMID: 25534916
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Body Mass Index Genetic Risk Score and Endometrial Cancer Risk.
Authors: Prescott J. , Setiawan V.W. , Wentzensen N. , Schumacher F. , Yu H. , Delahanty R. , Bernstein L. , Chanock S.J. , Chen C. , Cook L.S. , et al. .
Source: PloS one, 2015; 10(11), p. e0143256.
EPub date: 2015-11-25.
PMID: 26606540
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Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.
Authors: Setiawan V.W. , Schumacher F. , Prescott J. , Haessler J. , Malinowski J. , Wentzensen N. , Yang H. , Chanock S. , Brinton L. , Hartge P. , et al. .
Source: Carcinogenesis, 2014 Sep; 35(9), p. 2068-73.
EPub date: 2014-05-15.
PMID: 24832084
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Exome-wide association study of endometrial cancer in a multiethnic population.
Authors: Chen M.M. , Crous-Bou M. , Setiawan V.W. , Prescott J. , Olson S.H. , Wentzensen N. , Black A. , Brinton L. , Chen C. , Chen C. , et al. .
Source: PloS one, 2014; 9(5), p. e97045.
EPub date: 2014-05-08.
PMID: 24810602
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Type I and II endometrial cancers: have they different risk factors?
Authors: Setiawan V.W. , Yang H.P. , Pike M.C. , McCann S.E. , Yu H. , Xiang Y.B. , Wolk A. , Wentzensen N. , Weiss N.S. , Webb P.M. , et al. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-07-10; 31(20), p. 2607-18.
EPub date: 2013-06-03.
PMID: 23733771
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Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium.
Authors: Setiawan V.W. , Pike M.C. , Karageorgi S. , Deming S.L. , Anderson K. , Bernstein L. , Brinton L.A. , Cai H. , Cerhan J.R. , Cozen W. , et al. .
Source: American journal of epidemiology, 2012-08-15; 176(4), p. 269-78.
EPub date: 2012-07-23.
PMID: 22831825
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Long-term use of continuous-combined estrogen-progestin hormone therapy and risk of endometrial cancer.
Authors: Phipps A.I. , Doherty J.A. , Voigt L.F. , Hill D.A. , Beresford S.A. , Rossing M.A. , Chen C. , Weiss N.S. .
Source: Cancer causes & control : CCC, 2011 Dec; 22(12), p. 1639-46.
EPub date: 2011-09-11.
PMID: 21909949
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Polymorphisms in nucleotide excision repair genes and endometrial cancer risk.
Authors: Doherty J.A. , Weiss N.S. , Fish S. , Fan W. , Loomis M.M. , Sakoda L.C. , Rossing M.A. , Zhao L.P. , Chen C. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Sep; 20(9), p. 1873-82.
EPub date: 2011-07-12.
PMID: 21750170
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Pregnancy history and risk of endometrial cancer.
Authors: Pocobelli G. , Doherty J.A. , Voigt L.F. , Beresford S.A. , Hill D.A. , Chen C. , Rossing M.A. , Holmes R.S. , Noor Z.S. , Weiss N.S. .
Source: Epidemiology (Cambridge, Mass.), 2011 Sep; 22(5), p. 638-45.
PMID: 21691206
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The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women.
Authors: Lurie G. , Gaudet M.M. , Spurdle A.B. , Carney M.E. , Wilkens L.R. , Yang H.P. , Weiss N.S. , Webb P.M. , Thompson P.J. , Terada K. , et al. .
Source: PloS one, 2011-02-08; 6(2), p. e16756.
EPub date: 2011-02-08.
PMID: 21347432
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Maximizing resources to study an uncommon cancer: E2C2--Epidemiology of Endometrial Cancer Consortium.
Authors: Olson S.H. , Chen C. , De Vivo I. , Doherty J.A. , Hartmuller V. , Horn-Ross P.L. , Lacey J.V. , Lynch S.M. , Sansbury L. , Setiawan V.W. , et al. .
Source: Cancer causes & control : CCC, 2009 May; 20(4), p. 491-6.
EPub date: 2009-01-09.
PMID: 19132539
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Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium.
Authors: Setiawan V.W. , Doherty J.A. , Shu X.O. , Akbari M.R. , Chen C. , De Vivo I. , Demichele A. , Garcia-Closas M. , Goodman M.T. , Haiman C.A. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009 Jan; 18(1), p. 242-7.
PMID: 19124504
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Diabetes and endometrial cancer: an evaluation of the modifying effects of other known risk factors.
Authors: Saltzman B.S. , Doherty J.A. , Hill D.A. , Beresford S.A. , Voigt L.F. , Chen C. , Weiss N.S. .
Source: American journal of epidemiology, 2008-03-01; 167(5), p. 607-14.
EPub date: 2007-12-10.
PMID: 18071194
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Endometrial cancer risk in estrogen users after switching to estrogen-progestin therapy.
Authors: Chubak J. , Doherty J.A. , Cushing-Haugen K.L. , Voigt L.F. , Saltzman B.S. , Hill D.A. , Beresford S.A. , Weiss N.S. .
Source: Cancer causes & control : CCC, 2007 Nov; 18(9), p. 1001-7.
EPub date: 2007-07-25.
PMID: 17653829
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Long-term use of postmenopausal estrogen and progestin hormone therapies and the risk of endometrial cancer.
Authors: Doherty J.A. , Cushing-Haugen K.L. , Saltzman B.S. , Voigt L.F. , Hill D.A. , Beresford S.A. , Chen C. , Weiss N.S. .
Source: American journal of obstetrics and gynecology, 2007 Aug; 197(2), p. 139.e1-7.
PMID: 17689625
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Nucleotide excision repair genotype and the incidence of endometrial cancer: effect of other risk factors on the association.
Authors: Weiss J.M. , Weiss N.S. , Ulrich C.M. , Doherty J.A. , Chen C. .
Source: Gynecologic oncology, 2006 Dec; 103(3), p. 891-6.
EPub date: 2006-06-23.
PMID: 16806437
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Risk factors for the incidence of endometrial cancer according to the aggressiveness of disease.
Authors: Weiss J.M. , Saltzman B.S. , Doherty J.A. , Voigt L.F. , Chen C. , Beresford S.A. , Hill D.A. , Weiss N.S. .
Source: American journal of epidemiology, 2006-07-01; 164(1), p. 56-62.
EPub date: 2006-05-04.
PMID: 16675538
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Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer.
Authors: Weiss J.M. , Weiss N.S. , Ulrich C.M. , Doherty J.A. , Voigt L.F. , Chen C. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005 Nov; 14(11 Pt 1), p. 2524-30.
PMID: 16284373
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Genetic factors in catechol estrogen metabolism in relation to the risk of endometrial cancer.
Authors: Doherty J.A. , Weiss N.S. , Freeman R.J. , Dightman D.A. , Thornton P.J. , Houck J.R. , Voigt L.F. , Rossing M.A. , Schwartz S.M. , Chen C. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005 Feb; 14(2), p. 357-66.
PMID: 15734958
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Dose of progestin in postmenopausal-combined hormone therapy and risk of endometrial cancer.
Authors: Reed S.D. , Voigt L.F. , Beresford S.A. , Hill D.A. , Doherty J.A. , Weiss N.S. .
Source: American journal of obstetrics and gynecology, 2004 Oct; 191(4), p. 1146-51.
PMID: 15507934
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