Grant Number:	7R01CA085888-02 Interpret this number
Primary Investigator:	Loffredo, Christopher
Organization:	Georgetown University
Project Title:	Malignant Complications of Chronic Hepatitis C Virus
Fiscal Year:	2000

Chronic infection with hepatitis C virus (HCV) is a major public health problem, particularly in Egypt, where the prevalence of HCV infection is high. Among the long-term complications of HCV are hepatocellular carcinoma (HCC) and non-Hodgkin's lymphoma (NHL), but, particularly for NHL, few prospective studies have been done; hence, the incidence of malignant complications of chronic HCV is largely unknown. The contribution of other cancer risk factors also needs to be taken into account in assessing the HCV-associated risk of HCC and of NHL. Such factors include environmental exposures to carcinogens and inherited genetic susceptibilities, and new research is needed to investigate whether these risk factors can interact with HCV to modify the risks of malignancies in persons with chronic infections. In addition, the role of tumor suppressor genes in the biology of HCC and NHL cells needs to be addressed more fully. To fill these gaps in knowledge, this proposal builds upon an ongoing collaborative infrastructure of American and Egyptian scientists and research institutions to investigate the epidemiology of HCV- associated malignancies in Egypt. We propose to conduct: (1) a case-control study of the interrelationships among viral, genetic, and environmental risk factors for these two cancers; (2) a prospective study to estimate the incidence of HCC and NHL in persons with chronic HCV; and (3) a study of the mutational spectrum of the p53 gene in the tumor tissues of patients with HCC and NHL. Given the high prevalence of both HCV and HCV- related cancers in Egypt, the high potential for environmental exposures to carcinogenic chemicals there, and our demonstrated ability to collect biological samples and to obtain high-quality data from study subjects in Egypt, this proposal represents a unique opportunity to address important questions concerning the role of hepatitis C in these types of cancers.




Viral transmission risk factors in an Egyptian population with high hepatitis C prevalence.
Authors: Mohlman M.K. , Saleh D.A. , Ezzat S. , Abdel-Hamid M. , Korba B. , Shetty K. , Amr S. , Loffredo C.A. .
Source: Bmc Public Health, 2015-10-07 00:00:00.0; 15, p. 1030.
EPub date: 2015-10-07 00:00:00.0.
PMID: 26446713
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Preventing hepatocellular carcinoma in Egypt: results of a Pilot Health Education Intervention Study.
Authors: Saleh D.A. , Amr S. , Jillson I.A. , Wang J.H. , Crowell N. , Loffredo C.A. .
Source: Bmc Research Notes, 2015-08-29 00:00:00.0; 8, p. 384.
EPub date: 2015-08-29 00:00:00.0.
PMID: 26319021
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Multiple pregnancies, hepatitis C, and risk for hepatocellular carcinoma in Egyptian women.
Authors: Amr S. , Iarocci E.A. , Nasr G.R. , Saleh D. , Blancato J. , Shetty K. , Loffredo C.A. .
Source: Bmc Cancer, 2014-11-29 00:00:00.0; 14, p. 893.
EPub date: 2014-11-29 00:00:00.0.
PMID: 25432765
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Knowledge and perceptions of hepatitis C infection and pesticides use in two rural villages in Egypt.
Authors: Saleh D.A. , Amr S. , Jillson I.A. , Wang J.H. , Khairy W.A. , Loffredo C.A. .
Source: Bmc Public Health, 2014-05-24 00:00:00.0; 14, p. 501.
EPub date: 2014-05-24 00:00:00.0.
PMID: 24886607
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Evaluation of midkine as a diagnostic serum biomarker in hepatocellular carcinoma.
Authors: Zhu W.W. , Guo J.J. , Guo L. , Jia H.L. , Zhu M. , Zhang J.B. , Loffredo C.A. , Forgues M. , Huang H. , Xing X.J. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2013-07-15 00:00:00.0; 19(14), p. 3944-54.
EPub date: 2013-07-15 00:00:00.0.
PMID: 23719264
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Immunohistochemical detection of hepatitis C virus (genotype 4) in B-cell NHL in an Egyptian population: correlation with serum HCV-RNA.
Authors: Gouda I. , Nada O. , Ezzat S. , Eldaly M. , Loffredo C. , Taylor C. , Abdel-Hamid M. .
Source: Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication Of The Society For Applied Immunohistochemistry, 2010 Jan; 18(1), p. 29-34.
PMID: 19644357
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Viral and non-viral risk factors for non-Hodgkin's lymphoma in Egypt: heterogeneity by histological and immunological subtypes.
Authors: Goldman L. , Ezzat S. , Mokhtar N. , Abdel-Hamid A. , Fowler N. , Gouda I. , Eissa S.A. , Abdel-Hamid M. , Loffredo C.A. .
Source: Cancer Causes & Control : Ccc, 2009 Aug; 20(6), p. 981-7.
PMID: 19263231
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Detection of hepatocellular carcinoma using glycomic analysis.
Authors: Goldman R. , Ressom H.W. , Varghese R.S. , Goldman L. , Bascug G. , Loffredo C.A. , Abdel-Hamid M. , Gouda I. , Ezzat S. , Kyselova Z. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2009-03-01 00:00:00.0; 15(5), p. 1808-13.
EPub date: 2009-03-01 00:00:00.0.
PMID: 19223512
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Pilot survey of aflatoxin-albumin adducts in sera from Egypt.
Authors: Turner P.C. , Loffredo C. , Kafrawy S.E. , Ezzat S. , Eissa S.A. , Daly M.E. , Nada O. , Abdel-Hamid M. .
Source: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 2008 May; 25(5), p. 583-7.
PMID: 18473213
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Candidate markers for the detection of hepatocellular carcinoma in low-molecular weight fraction of serum.
Authors: Goldman R. , Ressom H.W. , Abdel-Hamid M. , Goldman L. , Wang A. , Varghese R.S. , An Y. , Loffredo C.A. , Drake S.K. , Eissa S.A. , et al. .
Source: Carcinogenesis, 2007 Oct; 28(10), p. 2149-53.
PMID: 17724376
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Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma.
Authors: Abdel-Hamid M. , El-Daly M. , Molnegren V. , El-Kafrawy S. , Abdel-Latif S. , Esmat G. , Strickland G.T. , Loffredo C. , Albert J. , Widell A. .
Source: The Journal Of General Virology, 2007 May; 88(Pt 5), p. 1526-31.
PMID: 17412982
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Peak selection from MALDI-TOF mass spectra using ant colony optimization.
Authors: Ressom H.W. , Varghese R.S. , Drake S.K. , Hortin G.L. , Abdel-Hamid M. , Loffredo C.A. , Goldman R. .
Source: Bioinformatics (oxford, England), 2007-03-01 00:00:00.0; 23(5), p. 619-26.
EPub date: 2007-03-01 00:00:00.0.
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Liver disease in Egypt: hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors.
Authors: Strickland G.T. .
Source: Hepatology (baltimore, Md.), 2006 May; 43(5), p. 915-22.
PMID: 16628669
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Associations of pesticides, HCV, HBV, and hepatocellular carcinoma in Egypt.
Authors: Ezzat S. , Abdel-Hamid M. , Eissa S.A. , Mokhtar N. , Labib N.A. , El-Ghorory L. , Mikhail N.N. , Abdel-Hamid A. , Hifnawy T. , Strickland G.T. , et al. .
Source: International Journal Of Hygiene And Environmental Health, 2005; 208(5), p. 329-39.
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Case-control study of non-Hodgkin's lymphoma and hepatitis C virus infection in Egypt.
Authors: Cowgill K.D. , Loffredo C.A. , Eissa S.A. , Mokhtar N. , Abdel-Hamid M. , Fahmy A. , Strickland G.T. .
Source: International Journal Of Epidemiology, 2004 Oct; 33(5), p. 1034-9.
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