Grant Number:	1R01CA090752-01 Interpret this number
Primary Investigator:	Cannon-Albright, Lisa
Organization:	University Of Utah
Project Title:	Mapping and Cloning Prostate Cancer Predisposition Loci
Fiscal Year:	2001

The identification of prostate cancer predisposition genes has proven to be a challenge for the prostate research community. Although several predisposition loci have been identified, none of these localizations has led to gene isolation, and only one of these findings has been significantly validated (Neuhausen et al.,1999). In Utah we have very recently isolated the first prostate cancer predisposition gene (see Tavtigian et al, submitted, in Appendix), and some confirmatory evidence has already been observed (Rebbeck et al., submitted). During our over 10 years of prostate cancer research we have collected a resource of almost 300 high-risk prostate cancer pedigrees, with approximately 8,000 DNA samples stored. These significant prostate cancer resources and contributions are evidence of the importance of the Utah prostate cancer effort, which we hope to continue through this proposal. We have previously had NIH funding (1994- 1998), and funding through a partnership with Schering Plough (1997-2000); both have ended. Our collaboration with Myriad Genetics continues. We are in the process of finalizing a collaborative agreement between our group, Myriad Genetics, NIH and Johns Hopkins (letters of support will follow), that will result in an open exchange of data, results, and genomic and genetic resources from all groups, and which we hope will contribute significantly to prostate genetic research. This proposal supports the University of Utah high-risk pedigree collection and analysis, and some Myriad genotyping effort towards this goal.




Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families.
Authors: Bailey-Wilson J.E. , Childs E.J. , Cropp C.D. , Schaid D.J. , Xu J. , Camp N.J. , Cannon-Albright L.A. , Farnham J.M. , George A. , Powell I. , et al. .
Source: Bmc Medical Genetics, 2012-06-19 00:00:00.0; 13, p. 46.
EPub date: 2012-06-19 00:00:00.0.
PMID: 22712434
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Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG.
Authors: Lu L. , Cancel-Tassin G. , Valeri A. , Cussenot O. , Lange E.M. , Cooney K.A. , Farnham J.M. , Camp N.J. , Cannon-Albright L.A. , Tammela T.L. , et al. .
Source: The Prostate, 2012 Mar; 72(4), p. 410-26.
PMID: 21748754
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Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses.
Authors: Christensen G.B. , Baffoe-Bonnie A.B. , George A. , Powell I. , Bailey-Wilson J.E. , Carpten J.D. , Giles G.G. , Hopper J.L. , Severi G. , English D.R. , et al. .
Source: The Prostate, 2010-05-15 00:00:00.0; 70(7), p. 735-44.
PMID: 20333727
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Assessment Of Snp Streak Statistics Using Gene Drop Simulation With Linkage Disequilibrium
Authors: Thomas A. .
Source: Genetic Epidemiology, 2010 Feb; 34(2), p. 119-24.
PMID: 19582786
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Replication Of The 10q11 And Xp11 Prostate Cancer Risk Variants: Results From A Utah Pedigree-based Study
Authors: Camp N.J. , Farnham J.M. , Wong J. , Christensen G.B. , Thomas A. , Cannon-Albright L.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Apr; 18(4), p. 1290-4.
PMID: 19336566
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No Evidence Of Brca2 Mutations In Chromosome 13q-linked Utah High-risk Prostate Cancer Pedigrees
Authors: Allen-Brady,K. , Farnham,J.M. , Camp,N.J. , Karlins,E. , Ostrander,E.A. , Cannon-Albright,L.A. .
Source: Bmc Research Notes, 2009; 2, p. 94.
PMID: 19476645
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A Parallel Genetic Algorithm To Discover Patterns In Genetic Markers That Indicate Predisposition To Multifactorial Disease
Authors: Rausch T. , Thomas A. , Camp N.J. , Cannon-Albright L.A. , Facelli J.C. .
Source: Computers In Biology And Medicine, 2008 Jul; 38(7), p. 826-36.
PMID: 18547558
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Shared Genomic Segment Analysis. Mapping Disease Predisposition Genes In Extended Pedigrees Using Snp Genotype Assays
Authors: Thomas A. , Camp N.J. , Farnham J.M. , Allen-Brady K. , Cannon-Albright L.A. .
Source: Annals Of Human Genetics, 2008 Mar; 72(Pt 2), p. 279-87.
PMID: 18093282
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Statistical Recombinant Mapping In Extended High-risk Utah Pedigrees Narrows The 8q24 Prostate Cancer Locus To 2.0 Mb
Authors: Camp N.J. , Farnham J.M. , Allen-Brady K. , Cannon-Albright L.A. .
Source: The Prostate, 2007-09-15 00:00:00.0; 67(13), p. 1456-64.
PMID: 17654497
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Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics.
Authors: Camp N.J. , Cannon-Albright L.A. , Farnham J.M. , Baffoe-Bonnie A.B. , George A. , Powell I. , Bailey-Wilson J.E. , Carpten J.D. , Giles G.G. , Hopper J.L. , et al. .
Source: Human Molecular Genetics, 2007-06-01 00:00:00.0; 16(11), p. 1271-8.
EPub date: 2007-06-01 00:00:00.0.
PMID: 17478474
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Genome-wide Linkage Analysis For Aggressive Prostate Cancer In Utah High-risk Pedigrees
Authors: Christensen G.B. , Camp N.J. , Farnham J.M. , Cannon-Albright L.A. .
Source: The Prostate, 2007-05-01 00:00:00.0; 67(6), p. 605-13.
PMID: 17299800
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Pooled Genome Linkage Scan Of Aggressive Prostate Cancer: Results From The International Consortium For Prostate Cancer Genetics
Authors: Schaid D.J. , McDonnell S.K. , Zarfas K.E. , Cunningham J.M. , Hebbring S. , Thibodeau S.N. , Eeles R.A. , Easton D.F. , Foulkes W.D. , Simard J. , et al. .
Source: Human Genetics, 2006 Nov; 120(4), p. 471-85.
PMID: 16932970
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Localization Of A Prostate Cancer Predisposition Gene To An 880-kb Region On Chromosome 22q12.3 In Utah High-risk Pedigrees
Authors: Camp N.J. , Farnham J.M. , Cannon-Albright L.A. .
Source: Cancer Research, 2006-10-15 00:00:00.0; 66(20), p. 10205-12.
PMID: 17047086
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Genomic Search For Prostate Cancer Predisposition Loci In Utah Pedigrees
Authors: Camp N.J. , Farnham J.M. , Cannon Albright L.A. .
Source: The Prostate, 2005-12-01 00:00:00.0; 65(4), p. 365-74.
PMID: 16037989
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Population-based Risk Assessment For Other Cancers In Relatives Of Hereditary Prostate Cancer (hpc) Cases
Authors: Albright L.A. , Schwab A. , Camp N.J. , Farnham J.S. , Thomas A. .
Source: The Prostate, 2005-09-01 00:00:00.0; 64(4), p. 347-55.
PMID: 15754348
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Identification And Study Of Utah Pseudo-isolate Populations-prospects For Gene Identification
Authors: Cannon-Albright L.A. , Farnham J.M. , Thomas A. , Camp N.J. .
Source: American Journal Of Medical Genetics. Part A, 2005-09-01 00:00:00.0; 137A(3), p. 269-75.
PMID: 16096997
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A Combined Genomewide Linkage Scan Of 1,233 Families For Prostate Cancer-susceptibility Genes Conducted By The International Consortium For Prostate Cancer Genetics
Authors: Xu J. , Dimitrov L. , Chang B.L. , Adams T.S. , Turner A.R. , Meyers D.A. , Eeles R.A. , Easton D.F. , Foulkes W.D. , Simard J. , et al. .
Source: American Journal Of Human Genetics, 2005 Aug; 77(2), p. 219-29.
PMID: 15988677
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Characterizing Allelic Associations From Unphased Diploid Data By Graphical Modeling
Authors: Thomas A. .
Source: Genetic Epidemiology, 2005 Jul; 29(1), p. 23-35.
PMID: 15838847
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Description Of The International Consortium For Prostate Cancer Genetics, And Failure To Replicate Linkage Of Hereditary Prostate Cancer To 20q13
Authors: Schaid D.J. , Chang B.L. , International Consortium For Prostate Cancer Genetics .
Source: The Prostate, 2005-05-15 00:00:00.0; 63(3), p. 276-90.
PMID: 15599943
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Characterization of linkage disequilibrium structure, mutation history, and tagging SNPs, and their use in association analyses: ELAC2 and familial early-onset prostate cancer.
Authors: Camp N.J. , Swensen J. , Horne B.D. , Farnham J.M. , Thomas A. , Cannon-Albright L.A. , Tavtigian S.V. .
Source: Genetic Epidemiology, 2005 Apr; 28(3), p. 232-43.
PMID: 15593091
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Confirmation Of The Hpcx Prostate Cancer Predisposition Locus In Large Utah Prostate Cancer Pedigrees
Authors: Farnham J.M. , Camp N.J. , Swensen J. , Tavtigian S.V. , Albright L.A. .
Source: Human Genetics, 2005 Feb; 116(3), p. 179-85.
PMID: 15592687
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Graphical modeling of the joint distribution of alleles at associated loci.
Authors: Thomas A. , Camp N.J. .
Source: American Journal Of Human Genetics, 2004 Jun; 74(6), p. 1088-101.
PMID: 15114533
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Principal component analysis for selection of optimal SNP-sets that capture intragenic genetic variation.
Authors: Horne B.D. , Camp N.J. .
Source: Genetic Epidemiology, 2004 Jan; 26(1), p. 11-21.
PMID: 14691953
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Association Of Common Missense Changes In Elac2 ( Hpc2) With Prostate Cancer In A Japanese Case-control Series
Authors: Fujiwara H. , Emi M. , Nagai H. , Nishimura T. , Konishi N. , Kubota Y. , Ichikawa T. , Takahashi S. , Shuin T. , Habuchi T. , et al. .
Source: Journal Of Human Genetics, 2002; 47(12), p. 641-8.
PMID: 12522685
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