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Grant Details

Grant Number: 1R01CA089139-01 Interpret this number
Primary Investigator: Henderson, Jeffery
Organization: Black Hills Ctr/American Indian Health
Project Title: Prospective Study of Alaska Natives & American Indians
Fiscal Year: 2001


DESCRIPTION: (Provided by applicant) Rates of chronic diseases vary substantially between American Indians and Alaska Natives (AIANs) and U.S. white populations for reasons that are largely unknown. Although little is known about factors that affect chronic diseases in AIANs, incidence rates for most chronic diseases are increasing. This 4-year proposal focuses on the development of an AIAN cohort to obtain a better understanding of the disparity in disease rates and risk factor knowledge that exist between AIANs and U.S. white populations. The purpose of this proposal is to develop valid and reliable methods to obtain diet, physical activity, and lifestyle information and to determine the most efficient and effective ways to recruit, enroll, and track study participants from diverse populations. We will work with local communities to develop culturally appropriate questionnaires that will accurately capture dietary intake, physical activity patterns lifestyle and cultural habits. We will work with local health providers and the Indian Health Service to access relevant study-related data from medical records and we will establish population-based recruitment methods. Starting in year 3 of the proposal, we will initiate recruitment and data collection, testing various protocols to determine the most efficient and effective way to conduct the study. We project that 2000 Alaska Natives, 3000 American Indians from the Navajo Nation, and 1500 American Indians from the Plains states will be enrolled over a 24-month time period. This number of participants is needed to adequately test our ability to enroll large numbers of individuals as well as determine potential burden to clinics as a result of enrollment. The major scientific goal of the AIAN cohort is to determine how diet, physical activity, and other lifestyle and cultural factors relate to the development and progression of chronic diseases such as cancer, cardiovascular disease, stroke, Type 2 diabetes, chronic lung and respiratory diseases, and related mortality from these diseases. Study data will be used to assess health status and identify groups of the population at risk for various health conditions. Longitudinal data will be used to identify factors that contribute to health and prevent disease. The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health.


Bone Mineral Density in Navajo Men and Women and Comparison to Non-Hispanic Whites from NHANES (2005-2008).
Authors: Miller K. , Frech T. , Greene T. , Ma K.N. , McFadden M. , Tom-Orme L. , Slattery M.L. , Murtaugh M.A. .
Source: Journal of health care for the poor and underserved, 2016; 27(2), p. 644-62.
PMID: 27180701
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Association of American Indian cultural identity with physical activity.
Authors: Duncan G.E. , McDougall C.L. , Dansie E. , Garroutte E. , Buchwald D. , Henderson J.A. .
Source: Ethnicity & disease, 2014 Winter; 24(1), p. 1-7.
PMID: 24620441
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Influence of caregiving on health-related quality of life among American Indians.
Authors: Spencer S.M. , Goins R.T. , Henderson J.A. , Wen Y. , Goldberg J. .
Source: Journal of the American Geriatrics Society, 2013 Sep; 61(9), p. 1615-20.
EPub date: 2013-09-03.
PMID: 24001320
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Physical activity and cervical cancer testing among American Indian women.
Authors: Muus K.J. , Baker-Demaray T.B. , Bogart T.A. , Duncan G.E. , Jacobsen C. , Buchwald D.S. , Henderson J.A. .
Source: The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association, 2012 Summer; 28(3), p. 320-6.
EPub date: 2011-09-20.
PMID: 22757957
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Soda intake and osteoporosis risk in postmenopausal American-Indian women.
Authors: Supplee J.D. , Duncan G.E. , Bruemmer B. , Goldberg J. , Wen Y. , Henderson J.A. .
Source: Public health nutrition, 2011 Nov; 14(11), p. 1900-6.
EPub date: 2011-01-04.
PMID: 21208477
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Culture and colorectal cancer screening on three American Indian reservations.
Authors: Perdue D.G. , Henderson J.A. , Garroutte E. , Bogart A. , Wen Y. , Goldberg J. , Buchwald D. .
Source: Ethnicity & disease, 2011 Summer; 21(3), p. 342-8.
PMID: 21942168
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Adult caregiving among American Indians: the role of cultural factors.
Authors: Goins R.T. , Spencer S.M. , McGuire L.C. , Goldberg J. , Wen Y. , Henderson J.A. .
Source: The Gerontologist, 2011 Jun; 51(3), p. 310-20.
EPub date: 2010-12-09.
PMID: 21148253
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The prevalence of metabolic syndrome and associated risk factors in Northern Plains and Southwest American Indians.
Authors: Sinclair K.A. , Bogart A. , Buchwald D. , Henderson J.A. .
Source: Diabetes care, 2011 Jan; 34(1), p. 118-20.
EPub date: 2010-09-23.
PMID: 20864516
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Validation of a dietary history questionnaire for American Indian and Alaska Native people.
Authors: Murtaugh M.A. , Ma K.N. , Greene T. , Redwood D. , Edwards S. , Johnson J. , Tom-Orme L. , Lanier A.P. , Henderson J.A. , Slattery M.L. .
Source: Ethnicity & disease, 2010 Autumn; 20(4), p. 429-36.
PMID: 21305833
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Epidemiology of physical activity in American Indians in the Education and Research Towards Health cohort.
Authors: Duncan G.E. , Goldberg J. , Buchwald D. , Wen Y. , Henderson J.A. .
Source: American journal of preventive medicine, 2009 Dec; 37(6), p. 488-94.
PMID: 19944913
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Patterns of cigarette smoking initiation in two culturally distinct American Indian tribes.
Authors: Nez Henderson P. , Kanekar S. , Wen Y. , Buchwald D. , Goldberg J. , Choi W. , Okuyemi K.S. , Ahluwalia J. , Henderson J.A. .
Source: American journal of public health, 2009 Nov; 99(11), p. 2020-5.
PMID: 19820215
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Primary liver cancer incidence among American Indians and Alaska Natives, US, 1999-2004.
Authors: Jim M.A. , Perdue D.G. , Richardson L.C. , Espey D.K. , Redd J.T. , Martin H.J. , Kwong S.L. , Kelly J.J. , Henderson J.A. , Ahmed F. .
Source: Cancer, 2008-09-01; 113(5 Suppl), p. 1244-55.
PMID: 18720380
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Gastric cancer among American Indians and Alaska Natives in the United States, 1999-2004.
Authors: Wiggins C.L. , Perdue D.G. , Henderson J.A. , Bruce M.G. , Lanier A.P. , Kelley J.J. , Seals B.F. , Espey D.K. .
Source: Cancer, 2008-09-01; 113(5 Suppl), p. 1225-33.
PMID: 18720378
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Prostate cancer incidence among American Indian and Alaska Native men, US, 1999-2004.
Authors: Henderson J.A. , Espey D.K. , Jim M.A. , German R.R. , Shaw K.M. , Hoffman R.M. .
Source: Cancer, 2008-09-01; 113(5 Suppl), p. 1203-12.
PMID: 18720376
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A prospective cohort of American Indian and Alaska Native people: study design, methods, and implementation.
Authors: Slattery M.L. , Schumacher M.C. , Lanier A.P. , Edwards S. , Edwards R. , Murtaugh M.A. , Sandidge J. , Day G.E. , Kaufman D. , Kanekar S. , et al. .
Source: American journal of epidemiology, 2007-09-01; 166(5), p. 606-15.
EPub date: 2007-06-22.
PMID: 17586578
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