Grant Number:	1R01CA088958-01 Interpret this number
Primary Investigator:	Slattery, Martha
Organization:	University Of Utah
Project Title:	A Prospective Study of Alaska Natives & American Indians
Fiscal Year:	2001

DESCRIPTION: (Provided by applicant) Rates of chronic diseases vary substantially between American Indians and Alaska Natives (AIANs) and U.S. white populations for reasons that are largely unknown. Although little is known about factors that affect chronic diseases in AIANs, incidence rates for most chronic diseases are increasing. This 4-year proposal focuses on the development of an AIAN cohort to obtain a better understanding of the disparity in disease rates and risk factor knowledge that exist between AIANs and U.S. white populations. The purpose of this proposal is to develop valid and reliable methods to obtain diet, physical activity, and lifestyle information and to determine the most efficient and effective ways to recruit, enroll, and track study participants from diverse populations. We will work with local communities to develop culturally appropriate questionnaires that will accurately capture dietary intake, physical activity patterns lifestyle and cultural habits. We will work with local health providers and the Indian Health Service to access relevant study-related data from medical records and we will establish population-based recruitment methods. Starting in year 3 of the proposal, we will initiate recruitment and data collection, testing various protocols to determine the most efficient and effective way to conduct the study. We project that 2000 Alaska Natives, 3000 American Indians from the Navajo Nation, and 1500 American Indians from the Plains states will be enrolled over a 24-month time period. This number of participants is needed to adequately test our ability to enroll large numbers of individuals as well as determine potential burden to clinics as a result of enrollment. The major scientific goal of the AIAN cohort is to determine how diet, physical activity, and other lifestyle and cultural factors relate to the development and progression of chronic diseases such as cancer, cardiovascular disease, stroke, Type 2 diabetes, chronic lung and respiratory diseases, and related mortality from these diseases. Study data will be used to assess health status and identify groups of the population at risk for various health conditions. Longitudinal data will be used to identify factors that contribute to health and prevent disease. The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health.




Evidence-based screening, clinical care and health education recommendations for Alaska Native peoples with prediabetes living in southcentral Alaska: findings from the Alaska EARTH follow-up study.
Authors: Koller K.R. , Nash S.H. , Beans J.A. , Day G.M. , Hiratsuka V.Y. , Lin A.L. , Narayanan M. , Patten C.A. , Hammock S.A. , Howard B.V. , et al. .
Source: International Journal Of Circumpolar Health, 2024 Dec; 83(1), p. 2343143.
EPub date: 2024-05-01 00:00:00.0.
PMID: 38691019
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Cancer Screening Prevalence among Participants in the Southcentral Alaska Education and Research towards Health (EARTH) Study at Baseline and Follow-Up.
Authors: Smayda L.C. , Day G.M. , Redwood D.G. , Beans J.A. , Hiratsuka V.Y. , Nash S.H. , Koller K.R. .
Source: International Journal Of Environmental Research And Public Health, 2023-08-18 00:00:00.0; 20(16), .
EPub date: 2023-08-18 00:00:00.0.
PMID: 37623179
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Smoking Patterns Among Urban Alaska Native and American Indian Adults: The Alaska EARTH 10-Year Follow-up Study.
Authors: Patten C.A. , Hiratsuka V.Y. , Nash S.H. , Day G. , Redwood D.G. , Beans J.A. , Howard B.V. , Umans J.G. , Koller K.R. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2022-04-28 00:00:00.0; 24(6), p. 840-846.
PMID: 34850172
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Ten-year weight gain is not associated with multiple cardiometabolic measures in Alaska EARTH study participants.
Authors: Nash S.H. , Day G. , Hiratsuka V.Y. , Beans J. , Redwood D. , Holck P. , Howard B.V. , Umans J. , Koller K.R. .
Source: Nutrition, Metabolism, And Cardiovascular Diseases : Nmcd, 2021-02-08 00:00:00.0; 31(2), p. 403-410.
EPub date: 2020-09-24 00:00:00.0.
PMID: 33127251
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Response to the letter.
Authors: Nash S.H. , Day G. , Hiratsuka V.Y. , Zimpelman G.L. , Koller K.R. .
Source: International Journal Of Circumpolar Health, 2020 12; 79(1), p. 1763718.
PMID: 32449642
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Increase in diabetes among urban Alaska Native people in the Alaska EARTH follow-up study: A call for prediabetes screening, diagnosis, and referral for intervention.
Authors: Koller K.R. , Day G.E. , Hiratsuka V.Y. , Beans J.A. , Nash S.H. , Redwood D.G. , Zhu J. , Howard B.V. , Umans J.G. .
Source: Diabetes Research And Clinical Practice, 2020 Sep; 167, p. 108357.
EPub date: 2020-07-31 00:00:00.0.
PMID: 32745696
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Cancer incidence and associations with known risk and protective factors: the Alaska EARTH study.
Authors: Nash S.H. , Day G. , Zimpelman G. , Hiratsuka V.Y. , Koller K.R. .
Source: Cancer Causes & Control : Ccc, 2019-08-19 00:00:00.0; , .
EPub date: 2019-08-19 00:00:00.0.
PMID: 31428891
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Bone Mineral Density in Navajo Men and Women and Comparison to Non-Hispanic Whites from NHANES (2005-2008).
Authors: Miller K. , Frech T. , Greene T. , Ma K.N. , McFadden M. , Tom-Orme L. , Slattery M.L. , Murtaugh M.A. .
Source: Journal Of Health Care For The Poor And Underserved, 2016; 27(2), p. 644-62.
PMID: 27180701
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Cardiometabolic correlates of low type 2 diabetes incidence in western Alaska Native people - The WATCH study.
Authors: Koller K.R. , Metzger J.S. , Jolly S.E. , Umans J.G. , Hopkins S.E. , Kaufmann C. , Wilson A.S. , Ebbesson S.O. , Raymer T.W. , Austin M.A. , et al. .
Source: Diabetes Research And Clinical Practice, 2015 Jun; 108(3), p. 423-31.
PMID: 25805711
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Sex differences in obesity prevalence and cardiometabolic factors among Western Alaska Native people.
Authors: Hopkins S.E. , Austin M.A. , Metzger J.S. , Koller K.R. , Umans J.G. , Kaufmann C. , Wolfe A.W. , Howard B.V. , Boyer B.B. .
Source: Nutrition, Metabolism, And Cardiovascular Diseases : Nmcd, 2015 Mar; 25(3), p. 312-8.
PMID: 25467216
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All-cause, cardiovascular, and cancer mortality in western Alaska Native people: western Alaska Tribal Collaborative for Health (WATCH).
Authors: Howard B.V. , Metzger J.S. , Koller K.R. , Jolly S.E. , Asay E.D. , Wang H. , Wolfe A.W. , Hopkins S.E. , Kaufmann C. , Raymer T.W. , et al. .
Source: American Journal Of Public Health, 2014 Jul; 104(7), p. 1334-40.
PMID: 24754623
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Utilizing harmonization and common surveillance methods to consolidate 4 cohorts: the Western Alaska Tribal Collaborative for Health (WATCH) study.
Authors: Koller K.R. , Wolfe A.W. , Metzger J.S. , Austin M.A. , Hopkins S.E. , Kaufmann C. , Jolly S.E. , Ebbesson S.O. , Umans J.G. , Howard B.V. , et al. .
Source: International Journal Of Circumpolar Health, 2013; 72, .
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Construct validity of the SF-12 among American Indian and Alaska Native people using two known scoring methods.
Authors: Edwards S.L. , McFadden M. , Lanier A.P. , Murtaugh M.A. , Ferucci E.D. , Redwood D.G. , Tom-Orme L. , Slattery M.L. .
Source: Journal Of Health Care For The Poor And Underserved, 2012 Aug; 23(3), p. 1123-36.
PMID: 24212164
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Prevalence of fracture and osteoporosis risk factors in American Indian and Alaska Native people.
Authors: Frech T. , Ma K.N. , Ferrucci E.D. , Lanier A.P. , McFadden M. , Tom-Orme L. , Slattery M.L. , Murtaugh M.A. .
Source: Journal Of Health Care For The Poor And Underserved, 2012 Aug; 23(3), p. 1157-73.
PMID: 24212166
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Reproductive cancer risk factors among Alaska Native women: the Alaska Education and Research Towards Health (EARTH) Study.
Authors: Redwood D.G. , Lanier A.P. , Johnston J.M. , Murphy N. , Murtaugh M.A. .
Source: Women's Health Issues : Official Publication Of The Jacobs Institute Of Women's Health, 2012 Jul-Aug; 22(4), p. e387-93.
PMID: 22609255
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Occupational and environmental exposures among Alaska Native and American Indian people living in Alaska and the Southwest United States.
Authors: Redwood D. , Lanier A.P. , Brubaker M. , Orell L. , Tom-Orme L. , George C. , Edwards S. , Slattery M. .
Source: Journal Of Environmental Health, 2012 May; 74(9), p. 22-8.
PMID: 22590848
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The Alaska Education and Research Towards Health (EARTH) Study: cancer risk factors.
Authors: Lanier A.P. , Redwood D.G. , Kelly J.J. .
Source: Journal Of Cancer Education : The Official Journal Of The American Association For Cancer Education, 2012 Apr; 27(1 Suppl), p. S80-5.
PMID: 22298198
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Depression prevalence and associated factors among Alaska Native people: the Alaska education and research toward health (EARTH) study.
Authors: Dillard D.A. , Smith J.J. , Ferucci E.D. , Lanier A.P. .
Source: Journal Of Affective Disorders, 2012 Feb; 136(3), p. 1088-97.
PMID: 22138285
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Self-reported asthma among American Indian and Alaska Native people in Alaska.
Authors: Orell L.J. , Ferucci E.D. , Lanier A.P. , Etzel R.A. .
Source: Journal Of Health Care For The Poor And Underserved, 2011 Nov; 22(4), p. 1264-78.
PMID: 22080708
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Validation of a dietary history questionnaire for American Indian and Alaska Native people.
Authors: Murtaugh M.A. , Ma K.N. , Greene T. , Redwood D. , Edwards S. , Johnson J. , Tom-Orme L. , Lanier A.P. , Henderson J.A. , Slattery M.L. .
Source: Ethnicity & Disease, 2010 Autumn; 20(4), p. 429-36.
PMID: 21305833
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Tobacco use among Alaska Native people in the EARTH study.
Authors: Smith J.J. , Ferucci E.D. , Dillard D.A. , Lanier A.P. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2010 Aug; 12(8), p. 839-44.
PMID: 20547558
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Differences in cigarette and smokeless tobacco use among American Indian and Alaska Native people living in Alaska and the Southwest United States.
Authors: Redwood D. , Lanier A.P. , Renner C. , Smith J. , Tom-Orme L. , Slattery M.L. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2010 Jul; 12(7), p. 791-6.
PMID: 20525781
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Chronic disease risk factors among Alaska Native and American Indian people, Alaska, 2004-2006.
Authors: Redwood D.G. , Lanier A.P. , Johnston J.M. , Asay E.D. , Slattery M.L. .
Source: Preventing Chronic Disease, 2010 Jul; 7(4), p. A85.
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Associations among body mass index, waist circumference, and health indicators in American Indian and Alaska Native adults.
Authors: Slattery M.L. , Ferucci E.D. , Murtaugh M.A. , Edwards S. , Ma K.N. , Etzel R.A. , Tom-Orme L. , Lanier A.P. .
Source: American Journal Of Health Promotion : Ajhp, 2010 Mar-Apr; 24(4), p. 246-54.
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Family health history and health behaviors in Alaska native and American Indian people.
Authors: Slattery M.L. , Murtaugh M.A. , Lanier A.P. , Ma K.N. , Ferucci E.D. , Etzel R.A. , Edwards S. .
Source: Journal Of Health Care For The Poor And Underserved, 2009 Aug; 20(3), p. 678-94.
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Physical activity patterns of American Indian and Alaskan Native people living in Alaska and the Southwestern United States.
Authors: Redwood D. , Schumacher M.C. , Lanier A.P. , Ferucci E.D. , Asay E. , Helzer L.J. , Tom-Orme L. , Edwards S.L. , Murtaugh M.A. , Slattery M.L. .
Source: American Journal Of Health Promotion : Ajhp, 2009 Jul-Aug; 23(6), p. 388-95.
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Factors associated with response to a follow-up postal questionnaire in a cohort of American Indians.
Authors: Edwards S.L. , Slattery M.L. , Edwards A.M. , Sweeney C. , Murtaugh M.A. , Palmer L.E. , Tom-Orme L. .
Source: Preventive Medicine, 2009 Jun; 48(6), p. 596-9.
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Visual impairment and eye care among Alaska Native people.
Authors: Haymes S.A. , Leston J.D. , Ferucci E.D. , Etzel R.A. , Lanier A.P. .
Source: Ophthalmic Epidemiology, 2009 May-Jun; 16(3), p. 163-74.
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Safety behaviours among Alaskan Native and American Indian people living in Alaska.
Authors: Redwood D.G. , Hagan K.D. , Perkins R.D. , Stafford H.B. , Orell L.J. , Lanier A.P. .
Source: Injury Prevention : Journal Of The International Society For Child And Adolescent Injury Prevention, 2009 Feb; 15(1), p. 30-5.
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Metabolic syndrome: prevalence among American Indian and Alaska native people living in the southwestern United States and in Alaska.
Authors: Schumacher C. , Ferucci E.D. , Lanier A.P. , Slattery M.L. , Schraer C.D. , Raymer T.W. , Dillard D. , Murtaugh M.A. , Tom-Orme L. .
Source: Metabolic Syndrome And Related Disorders, 2008 Dec; 6(4), p. 267-73.
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Prevalence and predictors of cancer screening among American Indian and Alaska native people: the EARTH study.
Authors: Schumacher M.C. , Slattery M.L. , Lanier A.P. , Ma K.N. , Edwards S. , Ferucci E.D. , Tom-Orme L. .
Source: Cancer Causes & Control : Ccc, 2008 Sep; 19(7), p. 725-37.
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Traditional foods and physical activity patterns and associations with cultural factors in a diverse Alaska Native population.
Authors: Redwood D.G. , Ferucci E.D. , Schumacher M.C. , Johnson J.S. , Lanier A.P. , Helzer L.J. , Tom-Orme L. , Murtough M.A. , Slattery M.L. .
Source: International Journal Of Circumpolar Health, 2008 Sep; 67(4), p. 335-48.
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Arthritis prevalence and associations in American Indian and Alaska Native people.
Authors: Ferucci E.D. , Schumacher M.C. , Lanier A.P. , Murtaugh M.A. , Edwards S. , Helzer L.J. , Tom-Orme L. , Slattery M.L. .
Source: Arthritis And Rheumatism, 2008-08-15 00:00:00.0; 59(8), p. 1128-36.
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A computer-assisted data collection system for use in a multicenter study of American Indians and Alaska Natives: SCAPES.
Authors: Edwards R.L. , Edwards S.L. , Bryner J. , Cunningham K. , Rogers A. , Slattery M.L. .
Source: Computer Methods And Programs In Biomedicine, 2008 Apr; 90(1), p. 38-55.
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Development, implementation, and evaluation of a computerized self-administered diet history questionnaire for use in studies of American Indian and Alaskan native people.
Authors: Slattery M.L. , Murtaugh M.A. , Schumacher M.C. , Johnson J. , Edwards S. , Edwards R. , Benson J. , Tom-Orme L. , Lanier A.P. .
Source: Journal Of The American Dietetic Association, 2008 Jan; 108(1), p. 101-9.
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A prospective cohort of American Indian and Alaska Native people: study design, methods, and implementation.
Authors: Slattery M.L. , Schumacher M.C. , Lanier A.P. , Edwards S. , Edwards R. , Murtaugh M.A. , Sandidge J. , Day G.E. , Kaufman D. , Kanekar S. , et al. .
Source: American Journal Of Epidemiology, 2007-09-01 00:00:00.0; 166(5), p. 606-15.
EPub date: 2007-09-01 00:00:00.0.
PMID: 17586578
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Development and use of touch-screen audio computer-assisted self-interviewing in a study of American Indians.
Authors: Edwards S.L. , Slattery M.L. , Murtaugh M.A. , Edwards R.L. , Bryner J. , Pearson M. , Rogers A. , Edwards A.M. , Tom-Orme L. .
Source: American Journal Of Epidemiology, 2007-06-01 00:00:00.0; 165(11), p. 1336-42.
EPub date: 2007-06-01 00:00:00.0.
PMID: 17379618
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What is the role of diet in the development of cancer in American Indian and Alaska native populations?
Authors: Slattery M.L. .
Source: Journal Of Cancer Education : The Official Journal Of The American Association For Cancer Education, 2005 Spring; 20(1 Suppl), p. 92-6.
PMID: 15916528
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