Grant Number:	1R01CA087477-01 Interpret this number
Primary Investigator:	Connolly, Gregory
Organization:	Massachusetts State Dept Of Pub Health
Project Title:	Design and Characterization of Cigarettes
Fiscal Year:	2000

DESCRIPTION: (Applicant's Description) The long term objective of this project is to advance scientific understanding about the design and function of tobacco products through the acquisition, analysis and reporting of internal tobacco industry documents held in the Minnesota and other court depositories. Particular attention will be paid to the use of additives and the design of low yield cigarettes. The specific aims of this project include understanding how changes in cigarette design contribute to youth smoking and nicotine dependence. Another aim is to determine how cigarettes are designed to reduce non-smokers' perception of second hand smoke. The project also hopes to improve scientific knowledge about the toxic and addictive properties of cigarettes by reviewing tobacco industry research on smoker behavior, changes in toxic constituents in mainstream and side stream smoke and changes in nicotine delivery over time. This project is relevant to national health policy. The Food and Drug Administration has declared tobacco products to be drug delivery devices and other govemments have proposed regulating tobacco products as drugs to reduce death and diseases associated with their use. This project will provide important scientific infonnation for the better characterization of tobacco product perfonnance and such characterization is essential to tobacco product regulation. The project will electronically access documents from the Minnesota and other depositories for selected topic areas. Relevant documents will be indexed using a standard thesaurus and placed both on the internet as well as searchable CD roms and made available to policy makers and the scientific community. Documents will be analyzed and scientific reports will be written on tobacco product design, regulation and characterization.




Looking Back and Ahead: The Food and Drug Administration's Regulation of the Tobacco Industry and Next-Generation Products.
Authors: Jacob M. .
Source: Advances In Dental Research, 2019 10; 30(1), p. 22-25.
PMID: 31538803
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Tobacco industry response to a ban on lights descriptors on cigarette packaging and population outcomes.
Authors: Alpert H.R. , Carpenter D. , Connolly G.N. .
Source: Tobacco Control, 2018 07; 27(4), p. 390-398.
EPub date: 2017-08-04 00:00:00.0.
PMID: 28778970
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A study of pyrazines in cigarettes and how additives might be used to enhance tobacco addiction.
Authors: Alpert H.R. , Agaku I.T. , Connolly G.N. .
Source: Tobacco Control, 2016 Jul; 25(4), p. 444-50.
PMID: 26063608
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The Role Of Cocoa As A Cigarette Additive: Opportunities For Product Regulation
Authors: Sokol N.A. , Kennedy R.D. , Connolly G.N. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2014 Jul; 16(7), p. 984-91.
PMID: 24610479
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Effectiveness of the cigarette ignition propensity standard in preventing unintentional residential fires in Massachusetts.
Authors: Alpert H.R. , Christiani D.C. , Orav E.J. , Dockery D.W. , Connolly G.N. .
Source: American Journal Of Public Health, 2014 Apr; 104(4), p. e56-61.
PMID: 24524537
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Has the tobacco industry evaded the FDA's ban on 'Light' cigarette descriptors?
Authors: Connolly G.N. , Alpert H.R. .
Source: Tobacco Control, 2014 Mar; 23(2), p. 140-5.
PMID: 23485704
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Gender and racial differences in smoking of long/ultra-long and king size cigarettes among U.S. adult smokers, NHANES 1999-2012.
Authors: Agaku I.T. , Vardavas C.I. , Ayo-Yusuf O.A. , Alpert H.R. , Connolly G.N. .
Source: Drug And Alcohol Dependence, 2014-03-01 00:00:00.0; 136, p. 28-35.
EPub date: 2014-03-01 00:00:00.0.
PMID: 24417962
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Cigarette rod length and its impact on serum cotinine and urinary total NNAL levels, NHANES 2007-2010.
Authors: Agaku I.T. , Vardavas C.I. , Connolly G.N. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2014 Jan; 16(1), p. 100-7.
PMID: 24057994
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Predictors and patterns of cigarette and smokeless tobacco use among adolescents in 32 countries, 2007-2011.
Authors: Agaku I.T. , Ayo-Yusuf O.A. , Vardavas C.I. , Connolly G. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2014 Jan; 54(1), p. 47-53.
PMID: 24060573
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Proposed cutoff for identifying adult smokeless tobacco users with urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol: an aggregated analysis of NHANES 2007-2010 data.
Authors: Agaku I.T. , Vardavas C.I. , Connolly G. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2013 Nov; 15(11), p. 1956-61.
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Use of conventional and novel smokeless tobacco products among US adolescents.
Authors: Agaku I.T. , Ayo-Yusuf O.A. , Vardavas C.I. , Alpert H.R. , Connolly G.N. .
Source: Pediatrics, 2013 Sep; 132(3), p. e578-86.
PMID: 23918889
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Tobacco Industry Strategies To Minimize Or Mask Cigarette Smoke: Opportunities For Tobacco Product Regulation
Authors: Kennedy R.D. , Millstein R.A. , Rees V.W. , Connolly G.N. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2013 Feb; 15(2), p. 596-602.
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Role of cigarette sensory cues in modifying puffing topography.
Authors: Rees V.W. , Kreslake J.M. , Wayne G.F. , O'Connor R.J. , Cummings K.M. , Connolly G.N. .
Source: Drug And Alcohol Dependence, 2012-07-01 00:00:00.0; 124(1-2), p. 1-10.
EPub date: 2012-07-01 00:00:00.0.
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Public attitudes regarding banning of cigarettes and regulation of nicotine.
Authors: Connolly G.N. , Behm I. , Healton C.G. , Alpert H.R. .
Source: American Journal Of Public Health, 2012 Apr; 102(4), p. e1-2.
PMID: 22397353
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Patterns Of Dual Use Of Cigarettes And Smokeless Tobacco Among Us Males: Findings From National Surveys
Authors: Tomar S.L. , Alpert H.R. , Connolly G.N. .
Source: Tobacco Control, 2010 Apr; 19(2), p. 104-9.
PMID: 20008157
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Human Electroencephalography And The Tobacco Industry: A Review Of Internal Documents
Authors: Panzano V.C. , Wayne G.F. , Pickworth W.B. , Connolly G.N. .
Source: Tobacco Control, 2010 Apr; 19(2), p. 153-9.
PMID: 20378591
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Regulatory Assessment Of Brand Changes In The Commercial Tobacco Product Market
Authors: Wayne G.F. , Connolly G.N. .
Source: Tobacco Control, 2009 Aug; 18(4), p. 302-9.
PMID: 19528042
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Developing Smokeless Tobacco Products For Smokers: An Examination Of Tobacco Industry Documents
Authors: Carpenter C.M. , Connolly G.N. , Ayo-Yusuf O.A. , Wayne G.F. .
Source: Tobacco Control, 2009 Feb; 18(1), p. 54-9.
PMID: 18948390
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The strategic targeting of females by transnational tobacco companies in South Korea following trade liberalization.
Authors: Lee K. , Carpenter C. , Challa C. , Lee S. , Connolly G.N. , Koh H.K. .
Source: Globalization And Health, 2009-01-30 00:00:00.0; 5, p. 2.
EPub date: 2009-01-30 00:00:00.0.
PMID: 19183443
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Tobacco Industry Manipulation Of Nicotine Dosing
Authors: Wayne G.F. , Carpenter C.M. .
Source: Handbook Of Experimental Pharmacology, 2009; (192), p. 457-85.
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Bringing 'Light, Life and Happiness': British American Tobacco and musicsponsorship in sub-Saharan Africa.
Authors: Patel P. , Okechukwu C.A. , Collin J. , Hughes B. .
Source: Third World Quarterly, 2009; 30(4), p. 685-700.
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After The Master Settlement Agreement: Targeting And Exposure Of Youth To Magazine Tobacco Advertising
Authors: Alpert H.R. , Koh H.K. , Connolly G.N. .
Source: Health Affairs (project Hope), 2008 Nov-Dec; 27(6), p. w503-12.
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Free Nicotine Content And Strategic Marketing Of Moist Snuff Tobacco Products In The United States: 2000-2006
Authors: Alpert H.R. , Koh H. , Connolly G.N. .
Source: Tobacco Control, 2008 Oct; 17(5), p. 332-8.
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Tobacco Industry Control Of Menthol In Cigarettes And Targeting Of Adolescents And Young Adults
Authors: Kreslake J.M. , Wayne G.F. , Alpert H.R. , Koh H.K. , Connolly G.N. .
Source: American Journal Of Public Health, 2008 Sep; 98(9), p. 1685-92.
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Tobacco Industry Research And Efforts To Manipulate Smoke Particle Size: Implications For Product Regulation
Authors: Wayne G.F. , Connolly G.N. , Henningfield J.E. , Farone W.A. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2008 Apr; 10(4), p. 613-25.
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The Menthol Smoker: Tobacco Industry Research On Consumer Sensory Perception Of Menthol Cigarettes And Its Role In Smoking Behavior
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Using Alcohol To Sell Cigarettes To Young Adults: A Content Analysis Of Cigarette Advertisements
Authors: Belstock S.A. , Connolly G.N. , Carpenter C.M. , Tucker L. .
Source: Journal Of American College Health : J Of Ach, 2008 Jan-Feb; 56(4), p. 383-9.
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Internal Tobacco Industry Research On Olfactory And Trigeminal Nerve Response To Nicotine And Other Smoke Components
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Trends In Nicotine Yield In Smoke And Its Relationship With Design Characteristics Among Popular Us Cigarette Brands, 1997-2005
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Source: Tobacco Control, 2007 Oct; 16(5), p. e5.
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The Role Of Sensory Perception In The Development And Targeting Of Tobacco Products
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Brand Differences Of Free-base Nicotine Delivery In Cigarette Smoke: The View Of The Tobacco Industry Documents
Authors: Ferris Wayne G. , Connolly G.N. , Henningfield J.E. .
Source: Tobacco Control, 2006 Jun; 15(3), p. 189-98.
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A Guide To Deciphering The Internal Codes Used By The Tobacco Industry
Authors: Cullen D. , Wayne G.F. , Connolly G. , Koh H. .
Source: Tobacco Control, 2005 Dec; 14(6), p. 429.
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New Cigarette Brands With Flavors That Appeal To Youth: Tobacco Marketing Strategies
Authors: Carpenter C.M. , Wayne G.F. , Pauly J.L. , Koh H.K. , Connolly G.N. .
Source: Health Affairs (project Hope), 2005 Nov-Dec; 24(6), p. 1601-10.
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Industry Research On The Use And Effects Of Levulinic Acid: A Case Study In Cigarette Additives
Authors: Keithly L. , Ferris Wayne G. , Cullen D.M. , Connolly G.N. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2005 Oct; 7(5), p. 761-71.
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Characterization Of Measured Menthol In 48 U.s. Cigarette Sub-brands
Authors: Celebucki C.C. , Wayne G.F. , Connolly G.N. , Pankow J.F. , Chang E.I. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2005 Aug; 7(4), p. 523-31.
PMID: 16085523
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Designing Cigarettes For Women: New Findings From The Tobacco Industry Documents
Authors: Carpenter C.M. , Wayne G.F. , Connolly G.N. .
Source: Addiction (abingdon, England), 2005 Jun; 100(6), p. 837-51.
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Smokers' Responses To Advertisements For Regular And Light Cigarettes And Potential Reduced-exposure Tobacco Products
Authors: Hamilton W.L. , Norton G. , Ouellette T.K. , Rhodes W.M. , Kling R. , Connolly G.N. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2004 Dec; 6 Suppl 3, p. S353-62.
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Assessing Internal Tobacco Industry Knowledge Of The Neurobiology Of Tobacco Dependence
Authors: Wayne G.F. , Connolly G.N. , Henningfield J.E. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2004 Dec; 6(6), p. 927-40.
PMID: 15801568
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Application, Function, And Effects Of Menthol In Cigarettes: A Survey Of Tobacco Industry Documents
Authors: Ferris Wayne G. , Connolly G.N. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2004 Feb; 6 Suppl 1, p. S43-54.
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One Size Does Not Fit All: How The Tobacco Industry Has Altered Cigarette Design To Target Consumer Groups With Specific Psychological And Psychosocial Needs
Authors: Cook B.L. , Wayne G.F. , Keithly L. , Connolly G. .
Source: Addiction (abingdon, England), 2003 Nov; 98(11), p. 1547-61.
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Percent Free Base Nicotine In The Tobacco Smoke Particulate Matter Of Selected Commercial And Reference Cigarettes
Authors: Pankow J.F. , Tavakoli A.D. , Luo W. , Isabelle L.M. .
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Does Menthol Enhance The Addictiveness Of Cigarettes? An Agenda For Research
Authors: Henningfield J.E. , Benowitz N.L. , Ahijevych K. , Garrett B.E. , Connolly G.N. , Wayne G.F. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2003 Feb; 5(1), p. 9-11.
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Eclipse: Does It Live Up To Its Health Claims?
Authors: Slade J. , Connolly G.N. , Lymperis D. .
Source: Tobacco Control, 2002 Jun; 11 Suppl 2, p. ii64-70.
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How Cigarette Design Can Affect Youth Initiation Into Smoking: Camel Cigarettes 1983-93
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Source: Tobacco Control, 2002 Mar; 11 Suppl 1, p. I32-9.
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