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Grant Details

Grant Number: 5R03CA083380-02 Interpret this number
Primary Investigator: Frosch, Dominick
Organization: Friends Research Institute, Inc.
Project Title: Smoking Cessation Outcomes in the Methadone Maintained
Fiscal Year: 2000


Substance abusers, and the methadone maintained in particular, smoke at exceptionally high rates, and hence experience disproportionately high risks for cancer. Although the methadone maintained express substantial interest in smoking cessation, effective interventions are still lacking. Previous research suggests that illicit substance use plays an important role in tobacco smoking for this group, but how this affects smoking cessation outcomes is not known. This project seeks to conduct secondary analyses, to determine predictors of outcome, on the first large scale (N=180) dataset on smoking cessation interventions for methadone maintained opiate abusers. The NIDA funded parent project which provides the basis for this proposal evaluated the efficacy of relapse prevention and contingency management for enhancing nicotine patch treatment outcomes in the methadone maintained. Secondary data analysis will be broken into two primary strategies: (1) Discriminant function analysis will be used to identify predictors of smoking cessation outcome during treatment, at the end of treatment, and at 6- and 12-month follow-up. (2) Latent growth models will be used to examine the causal relationship between tobacco relapse, and illicit drug use, and tobacco relapse and methadone dose. Findings will be used to generate empirically based risk indices for smoking cessation failure, which can be used by clinicians in designing optimally effective individualized interventions.


Optimizing smoking cessation outcomes among the methadone maintained.
Authors: Frosch D.L. , Nahom D. , Shoptaw S. .
Source: Journal of substance abuse treatment, 2002 Dec; 23(4), p. 425-30.
PMID: 12495806
Related Citations

Smoking cessation in methadone maintenance.
Authors: Shoptaw S. , Rotheram-Fuller E. , Yang X. , Frosch D. , Nahom D. , Jarvik M.E. , Rawson R.A. , Ling W. .
Source: Addiction (Abingdon, England), 2002 Oct; 97(10), p. 1317-28; discussion 1325.
PMID: 12359036
Related Citations

Using latent-variable models to analyze smoking cessation clinical trial data: an example among the methadone maintained.
Authors: Frosch D.L. , Stein J.A. , Shoptaw S. .
Source: Experimental and clinical psychopharmacology, 2002 Aug; 10(3), p. 258-67.
PMID: 12233986
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