DESCRIPTION: (Applicant's Description)
Obesity increases the risk of developing cancer, particularly hormone-
dependent cancer. Fifty-four percent of Americans are overweight or obese:
women and ethnic minorities have the highest rates. While obesity is the
result of an imbalance between energy intake and energy expenditure, the
etiology of obesity differs from person to person. Thus, no single obesity
prevention or treatment strategy will help every person; tailored inter-
ventions hold the greatest promise. We therefore propose to link genetic,
hormonal, and behavioral factors into individual obesity risk profiles to
identify those at risk of developing obesity and the best interventions for
them. We will capitalize on a unique data resource, the previously collected
demographic, dietary, and behavioral data and plasma and DNA samples from 550
European Americans and 225 African Americans in the Women's Health Initiative.
Our first aim is to ascertain the relationships between body mass index (BMI;
=weight in kg /height in m exp 2) and (i) putative genetic determinants of
obesity-related behavior, specifically two restriction fragment length
polymorphisms of the D2 dopamine receptor gene (DRD2); (ii) hormonal
determinants of obesity, specifically leptin, insulin-like growth factor 1
(IGF-1) and its major binding protein (BP-3), dehydroepiandrosterone DHEA) and
its sulfated conjugate (DHEAS), estrone, estradiol, and sex hormone-binding
globulin (SHBG);and (iii) behavioral determinants of obesity, including
tobacco use; excessive alcohol use; high dietary intake of total calories,
total fat, and total carbohydrates; low levels of physical activity; and
depression. We will also construct a comprehensive obesity risk assessment
profile of the most important genetic, hormonal, and behavioral, determinants
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