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Grant Details

Grant Number: 5R21CA081639-02 Interpret this number
Primary Investigator: Kozlowski, Lynn
Organization: Pennsylvania State University-Univ Park
Project Title: Rdd Surveys and Molecular Genetics of Cigarette Smoking
Fiscal Year: 2000


Cigarette smoking is a major cause of cancer disability and deaths in the U.S. There is a significant need for developing methodologies to obtain representative, cost-effective samples of persons (especially siblings) for genetic studies on cigarette smoking. We propose to study the feasibility of using Random-digit dialing (RDD) computer-assisted telephone interview (CATI) surveys to create an adult sample of current smokers, former smokers, and never smokers who will also provide buccal cell DNA samples by mail. The innovativeness derives from using RDD telephone surveys to link self-reports of smoking behavior to DNA. Differential cooperation rates will be estimated for a study will be "made anonymous" with no follow-up versus a study that will be trying to establish a registry for confidential follow-up research with the same individual. Biases in non-response will be estimated by exploring what factors (e.g., sex, age, smoking status, education, geographic region) predict non-response at subsequent levels. Finally, genetic analyses will be performed to assess effects of candidate genes (CYP2A6 and CYP2D6) related to smoking phenotypes (smoking status, heaviness of smoking, and sensitivity to the first cigarette of the day). This is a multi-disciplinary proposal involving the techniques of social science as well as of molecular genetics.


Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors.
Authors: Vandenbergh D.J. , O'Connor R.J. , Grant M.D. , Jefferson A.L. , Vogler G.P. , Strasser A.A. , Kozlowski L.T. .
Source: Addiction biology, 2007 Mar; 12(1), p. 106-16.
PMID: 17407504
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A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene.
Authors: Vandenbergh D.J. , Grant M.D. , Severns V. .
Source: Molecular and cellular probes, 2003 Dec; 17(6), p. 319-20.
PMID: 14602484
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Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: failure to replicate and finding that never-smokers may be different.
Authors: Vandenbergh D.J. , Bennett C.J. , Grant M.D. , Strasser A.A. , O'Connor R. , Stauffer R.L. , Vogler G.P. , Kozlowski L.T. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2002 Aug; 4(3), p. 333-40.
PMID: 12215242
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Using a telephone survey to acquire genetic and behavioral data related to cigarette smoking in "made-anonymous" and "registry" samples.
Authors: Kozlowski L.T. , Vogler G.P. , Vandenbergh D.J. , Strasser A.A. , O'Connor R.J. , Yost B.A. .
Source: American journal of epidemiology, 2002-07-01; 156(1), p. 68-77.
PMID: 12076890
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