||5R01CA081281-03 Interpret this number
||Columbia University Health Sciences
||Prostate Cancer Risk in Relation to Nutrition
The hypothesis that nutritional habits in childhood or adolescence
(particularly energy and/or fat intake) may be associated with increased
prostate cancer risk, possibly mediated through body size and/or weight
gain during particular periods of life, is currently receiving increased
attention. The purpose of the proposed investigation is to test this
hypothesis in a prospective cohort study. To define potential critical
exposure periods this study will specifically focus on the age at which
dietary restriction took place.
This investigation utilizes the unique setting in the Netherlands, a
western population where prostate cancer is common. In this country,
a substantial part of the population was exposed to a severe famine
towards the end (1944-1945) of World War II. In addition, nutrition was
compromised, albeit to a lesser degree, during the economic crisis of
the 1930s and in the early years of the wartime occupation which started
in 1940. In 1986, 58,279 men between the ages 55-69 were recruited for
a cohort study on diet and cancer risk in the Netherlands. A
substantial number of these men experienced the economic depression and
the wartime events in childhood. The impact of these exposures on body
size and prostate cancer incidence will be studied, as will the
association between childhood nutrition and stage at diagnosis.
The results of this investigation will provide highly relevant
prospective data on the relation between energy restriction in childhood
and subsequent prostate cancer risk in a nationally representative
sample of adult men.
Energy restriction in childhood and adolescence and risk of prostate cancer: results from the Netherlands Cohort Study.
, van den Brandt P.A.
, Goldbohm R.A.
, Lumey L.H.
American journal of epidemiology, 2001-09-15; 154(6), p. 530-7.