DESCRIPTION: (Applicant's Description)
Currently there are six million Americans alive with a history of cancer.
By the year 2000 overall cancer survival rates will be over 54 percent. As
people survive their cancers, there is the realization that they have
psychosocial issues and long-term effects of cancer therapy with which to
deal. This research project is designed to evaluate quality of life issues
and late effects of normal tissues from primary cancer treatment in patients
surviving at least five years that are alive without cancer. There are
three objectives for this research project. 1. Define the issues
surrounding the late effects from therapy in long-term survivors of HNC and
prostate cancer patients. The opportunity exists to look at these long-term
effects in a database of over 4,600 prostate cancer patients and over 2,700
HNC cancer patients. These comprise a unique patient population of the
Radiation Therapy Oncology Group (RTOG), both in size and breadth. The
validation of the Late Effects of Normal Tissue (LENT) and Subjective,
Objective, Management, and Analytic (SOMA) tools in HNC and prostate cancer
patients can be done in this population. 2. Describe the significant
issues in quality of life in HNC and prostate cancer survivors. These
include sexual functioning, marital problems, social, physical, emotional,
and spiritual well-being. Factors that may affect these endpoints include
the ability to work and obtain insurance, socioeconomic status, age, and
gender. 3. Through objectives one and two, design interventional studies
to prevent or alleviate late effects. All data collected through this
project will be centrally reviewed and appended to an established clinical
patient record. Because all patients enrolled in this project are already
participating in RTOG therapeutic clinical trials, there exists a
prospective clinical record. The addition of this project will provide a
prospective, continuous profile of clinical, quality of life, and acute and
late effects data on long-term survivors of HNC and prostate cancer. This
project will create one of the largest databases, both in size and breadth,
of long-term survivors of HNC and prostate cancer.
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- The DCCPS Team.