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Grant Details

Grant Number: 5R01CA082562-02 Interpret this number
Primary Investigator: Narod, Steven
Organization: University Of Toronto
Project Title: Mammographic Density and Risk of Hereditary Breast Canc
Fiscal Year: 2000
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Abstract

DESCRIPTION: (Adapted from the Investigator's Abstract) Two of the strongest risk factors for breast cancer are the presence of a mutation in BRCA1 or BRCA2, and increased mammographic density. It is estimated that the risk of early-onset breast cancer is increased by 25-fold in women who carry a pathogenic mutation in either BRCA1 or BRCA2. It is also estimated that women who are in the highest quintile of mammographic density experience a five-fold increase for breast cancer. However, it is not known if the two risk factors are independent. If so, then women with a BRCA1 or BRCA2 mutation who also show high density patterns on a screening mammogram will form a subgroup at particularly high risk. It is important to establish the magnitude of this association if accurate risk estimates are to be given in a clinical setting. There is considerable interest in identifying intermediate markers of risk for chemoprevention studies in high-risk women. One potential marker is mammographic density. However, prior to the acceptance of mammographic density as a surrogate marker of risk in BRCA1 and BRCA2 carriers, it is essential to establish whether or not this risk factor is relevant for hereditary breast cancer. The present study is a case-control study of 120 hereditary breast cancer cases and 120 unaffected age-matched carrier controls. Screening mammograms performed prior to the occurrence of breast cancer in the case will be evaluated for mammographic density and compared with those of the controls. Relative risks for mammographic density will be estimated by degree of mammographic density.

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Publications

LPA receptor 2 mediates LPA-induced endometrial cancer invasion.
Authors: Hope J.M. , Wang F.Q. , Whyte J.S. , Ariztia E.V. , Abdalla W. , Long K. , Fishman D.A. .
Source: Gynecologic oncology, 2009 Jan; 112(1), p. 215-23.
EPub date: 2008-11-18.
PMID: 19019417
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S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac.
Authors: Devine K.M. , Smicun Y. , Hope J.M. , Fishman D.A. .
Source: Gynecologic oncology, 2008 Aug; 110(2), p. 237-45.
EPub date: 2008-05-29.
PMID: 18513786
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S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells.
Authors: Smicun Y. , Gil O. , Devine K. , Fishman D.A. .
Source: Gynecologic oncology, 2007 Nov; 107(2), p. 298-309.
EPub date: 2007-08-22.
PMID: 17716713
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Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cells.
Authors: Do T.V. , Symowicz J.C. , Berman D.M. , Liotta L.A. , Petricoin E.F. , Stack M.S. , Fishman D.A. .
Source: Molecular cancer research : MCR, 2007 Feb; 5(2), p. 121-31.
PMID: 17314270
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S1P regulation of ovarian carcinoma invasiveness.
Authors: Smicun Y. , Reierstad S. , Wang F.Q. , Lee C. , Fishman D.A. .
Source: Gynecologic oncology, 2006 Dec; 103(3), p. 952-9.
EPub date: 2006-09-07.
PMID: 16956652
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Inhibition of matrilysin expression by antisense or RNA interference decreases lysophosphatidic acid-induced epithelial ovarian cancer invasion.
Authors: Wang F.Q. , Smicun Y. , Calluzzo N. , Fishman D.A. .
Source: Molecular cancer research : MCR, 2006 Nov; 4(11), p. 831-41.
PMID: 17114341
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Matrilysin over-expression in MCF-7 cells enhances cellular invasiveness and pro-gelatinase activation.
Authors: Wang F. , Reierstad S. , Fishman D.A. .
Source: Cancer letters, 2006-05-18; 236(2), p. 292-301.
EPub date: 2005-07-12.
PMID: 16019136
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Vascular endothelial growth factor-regulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinases.
Authors: Wang F.Q. , So J. , Reierstad S. , Fishman D.A. .
Source: International journal of cancer, 2006-02-15; 118(4), p. 879-88.
PMID: 16152587
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Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cells.
Authors: Meng Y. , Kang S. , Fishman D.A. .
Source: Cancer immunology, immunotherapy : CII, 2005 Aug; 54(8), p. 807-14.
EPub date: 2005-01-21.
PMID: 15662527
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LPA-induced epithelial ovarian cancer (EOC) in vitro invasion and migration are mediated by VEGF receptor-2 (VEGF-R2).
Authors: So J. , Wang F.Q. , Navari J. , Schreher J. , Fishman D.A. .
Source: Gynecologic oncology, 2005 Jun; 97(3), p. 870-8.
PMID: 15919106
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The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer.
Authors: Fishman D.A. , Cohen L. , Blank S.V. , Shulman L. , Singh D. , Bozorgi K. , Tamura R. , Timor-Tritsch I. , Schwartz P.E. .
Source: American journal of obstetrics and gynecology, 2005 Apr; 192(4), p. 1214-21; discussion 1221-2.
PMID: 15846205
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Estradiol-induced ezrin overexpression in ovarian cancer: a new signaling domain for estrogen.
Authors: Song J. , Fadiel A. , Edusa V. , Chen Z. , So J. , Sakamoto H. , Fishman D.A. , Naftolin F. .
Source: Cancer letters, 2005-03-18; 220(1), p. 57-65.
PMID: 15737688
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Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase.
Authors: Wang F.Q. , So J. , Reierstad S. , Fishman D.A. .
Source: International journal of cancer, 2005-03-10; 114(1), p. 19-31.
PMID: 15523695
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Translocation of Fas by LPA prevents ovarian cancer cells from anti-Fas-induced apoptosis.
Authors: Meng Y. , Kang S. , So J. , Reierstad S. , Fishman D.A. .
Source: Gynecologic oncology, 2005 Feb; 96(2), p. 462-9.
PMID: 15661236
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Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytes.
Authors: Meng Y. , Graves L. , Do T.V. , So J. , Fishman D.A. .
Source: Gynecologic oncology, 2004 Dec; 95(3), p. 488-95.
PMID: 15581951
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